MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

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Showing element 451 to 500 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	Interaction Map	red	network_comparison	green
113	natural resistance-associated macrophage protein 2 (nramp 2) (divalent metal transporter 1) (dmt1). [swissprot;acc:p49281]	SLC11A2	Subtracted	Low confidence	224.763	14.197	210.566
	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	PPP2CA		High confidence	194.372	39.832	234.204
114	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	MRPS17		Low confidence	58	14	44
	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]	B9D1		High confidence	229.818	37.447	267.265
	disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490]	DLGAP1	Divided	Low confidence	197.779	1.07182	211.983
	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	KHDRBS1		High confidence	332.874	1.24557	267.246
115	disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0]	DLGAP4		Low confidence	197.779	1.07182	211.983
	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	HAT1	Subtracted	High confidence	277.546	37.085	240.461
	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	KHDRBS2	Divided		332.874	1.24557	267.246
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	SLC25A43	Subtracted	Low confidence	58	14	44
116	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	GNB3	Divided	High confidence	268.565	1.24545	334.483
	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	HMG20B	Subtracted		208.52	36.925	171.595
	testican-3 precursor. [swissprot;acc:q9bq16]	no value		Low confidence	220.395	13.994	234.389
	vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253]	VPS18	Divided		204.161	1.07008	190.791
117	coagulation factor xiii a chain precursor (ec 2.3.2.13) (protein- glutamine gamma-glutamyltransferase a chain) (transglutaminase a chain). [swissprot;acc:p00488]	F13A1			226.395	1.06935	211.713
	high-mobility group 20a. [refseq;acc:nm_018200]	HMG20A	Subtracted	High confidence	208.588	36.81	171.778
	neuralized-like. [refseq;acc:nm_004210]	NEURL	Divided		332.326	1.24491	266.948
	striated muscle activator of rho-dependent signaling. [refseq;acc:nm_139166]	ABRA	Subtracted	Low confidence	225.495	13.966	211.529
118	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	NDUFA12	Divided	High confidence	284.753	1.24382	228.934
	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	OSR1	Subtracted		274.027	36.237	237.79
	protein-glutamine gamma-glutamyltransferase k (ec 2.3.2.13) (transglutaminase k) (tgase k) (tgk) (tg(k)) (transglutaminase 1) (epidermal tgase). [swissprot;acc:p22735]	TGM1	Divided	Low confidence	226.395	1.06935	211.713
	testican-1 precursor (spock protein). [swissprot;acc:q08629]	SPOCK1	Subtracted		220.254	13.857	234.111
119	adiponectin receptor 2. [refseq;acc:nm_024551]	ADIPOR2		High confidence	281.582	35.211	246.371
	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]	NDUFS4	Divided		318.982	1.23157	259.004
	natural resistance-associated macrophage protein 1 (nramp 1). [swissprot;acc:p49279]	SLC11A1		Low confidence	225.666	1.06897	211.107
	testican-2 precursor. [swissprot;acc:q92563]	SPOCK2	Subtracted		220.222	13.825	234.047
120	nanos (fragment). [sptrembl;acc:q8wy41]	no value			203.66	13.819	217.479
	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483]	TIA1		High confidence	227.199	34.484	192.715
	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	KCND2	Divided		269.278	1.21699	327.709
	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	DVL1		Low confidence	203.016	1.0687	189.965
121	cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929]	CTH		High confidence	269.254	1.2169	327.655
	nucleolysin tiar (tia-1 related protein). [swissprot;acc:q01085]	TIAL1	Subtracted		227.202	34.379	192.823
	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	DVL2	Divided	Low confidence	203.007	1.06854	189.985
	vacuolar protein sorting 33a (hvps33a). [swissprot;acc:q96ax1]	VPS33A	Subtracted		203.914	13.725	190.189
122	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]	COPS3		High confidence	199.949	34.238	234.187
	nanos (fragment). [sptrembl;acc:q8wy41]	no value	Divided	Low confidence	203.66	1.06785	217.479
	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	KCND3		High confidence	269.248	1.21688	327.642
	vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253]	VPS18	Subtracted	Low confidence	204.161	13.37	190.791
123	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]	KCND1	Divided	High confidence	269.23	1.21681	327.601
	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	DVL3		Low confidence	202.96	1.06768	190.094
	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641]	SNRPD1	Subtracted	High confidence	227.032	33.976	193.056
	striatin. [swissprot;acc:o43815]	STRN		Low confidence	214.085	13.289	200.796
124	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]	DAZAP1			220.268	13.271	206.997
	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	HMG20B	Divided	High confidence	208.52	1.21519	171.595
	natural resistance-associated macrophage protein 2 (nramp 2) (divalent metal transporter 1) (dmt1). [swissprot;acc:p49281]	SLC11A2		Low confidence	224.763	1.06742	210.566
	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	PSEN2	Subtracted	High confidence	285.684	33.45	252.234
125	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]	B9D1	Divided	Low confidence	213.243	1.0674	227.616
	high-mobility group 20a. [refseq;acc:nm_018200]	HMG20A		High confidence	208.588	1.21429	171.778
	prominin-like protein 1 precursor (antigen ac133) (cd133 antigen). [swissprot;acc:o43490]	PROM1	Subtracted	Low confidence	220.268	13.271	206.997
	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	SKP1A		High confidence	285.684	33.45	252.234

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.