MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Rank	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 451 to 500 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Value Type	Network Comparison Type	red	green	network_comparison
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]	1040	SRD5A1	Ranked	Subtracted	220.118	213.685	6.433
	1083			Divided			1.03011
	1244		Measured	Subtracted	5885	6371.14	486.14
	1274			Divided			1.08261
	2526		Squared	Subtracted	28935	30015.7	1080.7
	2609			Divided			1.03735
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213]	960	SRD5A2	Rooted	Subtracted	61.6649	65.1892	3.5243
	972			Divided			1.05715
	1041		Ranked	Subtracted	220.118	213.685	6.433
	1084			Divided			1.03011
	1245		Measured	Subtracted	5885	6371.14	486.14
	1275			Divided			1.08261
	2527		Squared	Subtracted	28935	30015.7	1080.7
	2610			Divided			1.03735
3-phosphoinositide dependent protein kinase-1 (ec 2.7.1.37) (hpdk1). [swissprot;acc:o15530]	739	PDPK1	Ranked	Subtracted	272.878	283.472	10.594
	897			Divided			1.03882
	2394		Rooted		43.4014	42.7253	1.01582
	2500			Subtracted			0.6761
	2547		Measured	Divided	3370.46	3444.18	1.02187
	2627			Subtracted			73.72
	2650		Squared	Divided	16658.1	16197	1.02847
	2675			Subtracted			461.1
38 kda fk-506 binding protein homolog (fkbpr38) (fk506-binding protein 8). [swissprot;acc:q14318]	1714	FKBP8	Rooted		67.8897	69.9589	2.0692
	1826			Divided			1.03048
	2133		Measured	Subtracted	6486.84	6786.23	299.39
	2261			Divided			1.04615
	2358		Ranked		198.181	197.346	1.00423
	2385			Subtracted			0.835
	2679		Squared		27920.7	28336.5	415.8
	2710			Divided			1.01489
4-aminobutyrate aminotransferase, mitochondrial precursor (ec 2.6.1.19) (gamma-amino-n-butyrate transaminase) (gaba transaminase) (gaba aminotransferase) (gaba-at) (gaba-t). [swissprot;acc:p80404]	696	no value			22778.5	26693.1	1.17186
	823			Subtracted			3914.6
	1469		Measured	Divided	5473.09	5887.45	1.07571
	1658			Subtracted			414.36
	1720		Ranked		219.423	222.215	2.792
	1745			Divided			1.01272
	2352		Rooted		60.9091	61.9962	1.01785
	2363			Subtracted			1.0871
40s ribosomal protein s11. [swissprot;acc:p04643]	199	RPS11	Ranked		241.399	267.088	25.689
	278			Divided			1.10642
	335		Rooted		50.4705	45.5342	1.10841
	585			Subtracted			4.9363
	1873		Measured	Divided	3618.46	3402.09	1.0636
	2016		Squared		12389	13514	1.09081
	2360		Measured	Subtracted	3618.46	3402.09	216.37
	2517		Squared		12389	13514	1125
40s ribosomal protein s13. [swissprot;acc:q02546]	776	RPS13		Divided	21976	25607.9	1.16527
	936			Subtracted			3631.9
	1498		Measured	Divided	5414.98	5818.7	1.07456
	1677			Subtracted			403.72

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.