MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Rank	Network Comparison Type	Hugo	Value Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 451 to 500 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Interaction Map	red	green	network_comparison
adapter-related protein complex 1 beta 1 subunit (beta-adaptin 1) (adaptor protein complex ap-1 beta-1 subunit) (golgi adaptor ha1/ap1 adaptin beta subunit) (clathrin assembly protein complex 1 beta large chain). [swissprot;acc:q10567]	1586	AP1B1	High confidence	222.166	225.79	1.01631
adapter-related protein complex 1 gamma 1 subunit (gamma-adaptin) (adaptor protein complex ap-1 gamma-1 subunit) (golgi adaptor ha1/ap1 adaptin gamma-1 subunit) (clathrin assembly protein complex 1 gamma-1 large chain). [swissprot;acc:o43747]	416	AP1G1	Low confidence	207.442	200.339	1.03545
	1596		High confidence	222.134	225.731	1.01619
adapter-related protein complex 1 gamma 2 subunit (gamma2-adaptin) (adaptor protein complex ap-1 gamma-2 subunit) (g2ad). [swissprot;acc:o75843]	408	JPH4	Low confidence	207.558	200.363	1.03591
	1594		High confidence	222.133	225.731	1.0162
adapter-related protein complex 1 sigma 1a subunit (sigma-adaptin 1a) (adaptor protein complex ap-1 sigma-1a subunit) (golgi adaptor ha1/ap1 adaptin sigma-1a subunit) (clathrin assembly protein complex 1 sigma- 1a small chain) (clathrin coat assembly protein ap19) (ha1 19 kda subunit) (sigma 1a subunit of ap-1 clathrin). [swissprot;acc:q00382]	699	AP1S1	Low confidence	205.169	199.601	1.0279
	1598		High confidence	222.134	225.731	1.01619
adapter-related protein complex 1 sigma 1b subunit (sigma-adaptin 1b) (adaptor protein complex ap-1 sigma-1b subunit) (golgi adaptor ha1/ap1 adaptin sigma-1b subunit) (clathrin assembly protein complex 1 sigma- 1b small chain) (sigma 1b subunit of ap-1 clathrin) (dc22). [swissprot;acc:p56377]	693	no value	Low confidence	205.207	199.613	1.02802
	1595		High confidence	222.134	225.731	1.01619
adapter-related protein complex 1 sigma 1c subunit (sigma-adaptin 1c) (adaptor protein complex ap-1 sigma-1c subunit) (golgi adaptor ha1/ap1 adaptin sigma-1c subunit) (clathrin assembly protein complex 1 sigma- 1c small chain) (sigma 1c subunit of ap-1 clathrin). [swissprot;acc:q96pc3]	777	AP1S3	Low confidence	204.807	199.484	1.02668
	1597		High confidence	222.134	225.731	1.01619
adapter-related protein complex 2 alpha 1 subunit (alpha-adaptin a) (adaptor protein complex ap-2 alpha-1 subunit) (clathrin assembly protein complex 2 alpha-a large chain) (100 kda coated vesicle protein a) (plasma membrane adaptor ha2/ap2 adaptin alpha a subunit). [swissprot;acc:o95782]	352	no value	Low confidence	204.762	197.135	1.03869
adapter-related protein complex 2 alpha 2 subunit (alpha-adaptin c) (clathrin assembly protein complex 2 alpha-c large chain) (100 kda coated vesicle protein c) (plasma membrane adaptor ha2/ap2 adaptin alpha c subunit) (huntingtin-interacting protein hypj). [swissprot;acc:o94973]	349	AP2A2
adapter-related protein complex 2 beta 1 subunit (beta-adaptin) (plasma membrane adaptor ha2/ap2 adaptin beta subunit) (clathrin assembly protein complex 2 beta large chain) (ap105b). [swissprot;acc:p21851]	437	AP2B1		207.064	200.076	1.03493
	1600		High confidence	222.103	225.675	1.01608
adapter-related protein complex 3 beta 1 subunit (beta-adaptin 3a) (ap-3 complex beta-3a subunit) (beta-3a-adaptin). [swissprot;acc:o00203]	2044	AP3B1		199.928	198.24	1.00851
	4836		Low confidence	209.715	210.462	1.00356
adapter-related protein complex 3 beta 2 subunit (beta-adaptin 3b) (ap-3 complex beta-3b subunit) (beta-3b-adaptin) (neuron-specific vesicle coat protein beta-nap). [swissprot;acc:q13367]	2046	no value	High confidence	199.928	198.24	1.00851
	4800		Low confidence	210.222	211.108	1.00421
adapter-related protein complex 3 delta 1 subunit (delta-adaptin 3) (ap-3 complex delta subunit) (delta-adaptin). [swissprot;acc:o14617]	4897	AP3D1		205.262	204.814	1.00219
adapter-related protein complex 3 mu 1 subunit (mu-adaptin 3a) (ap-3 adapter complex mu3a subunit). [swissprot;acc:q9y2t2]	1098	AP3M1	High confidence	217.323	211.185	1.02906
	1641		Low confidence	202.78	198.661	1.02073
adapter-related protein complex 3 mu 2 subunit (clathrin coat assembly protein ap47 homolog 2) (clathrin coat associated protein ap47 homolog 2) (golgi adaptor ap-1 47 kda protein homolog 2) (ha1 47 kda subunit homolog 2) (clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (p47b). [swissprot;acc:p53677]	1099	AP3M2	High confidence	217.315	211.183	1.02904
	1640		Low confidence	202.787	198.666	1.02074
adaptor protein with pleckstrin homology and src homology 2 domains. [refseq;acc:nm_020979]	2870	SH2B2	High confidence	0.00001	0.00001	1
	3053		Low confidence	199.658	196.399	1.01659
adaptor-associated kinase 1. [refseq;acc:nm_014911]	1383	AAK1	High confidence	218.47	213.876	1.02148
	2380		Low confidence	200.958	197.301	1.01854
adaptor-related protein complex 1, mu 1 subunit (mu-adaptin 1) (adaptor protein complex ap-1 mu-1 subunit) (golgi adaptor ha1/ap1 adaptin mu-1 subunit) (clathrin assembly protein assembly protein complex 1 medium chain 1) (clathrin coat assembly protein ap47) (clathrin coat associated protein ap47) (ap-mu chain family member mu1a). [swissprot;acc:q9bxs5]	553	AP1M1		205.75	199.452	1.03158
	1770		High confidence	221.082	223.778	1.01219
adaptor-related protein complex 1, mu 2 subunit (mu-adaptin 2) (adaptor protein complex ap-1 mu-2 subunit) (golgi adaptor ha1/ap1 adaptin mu-2 subunit) (clathrin assembly protein assembly protein complex 1 medium chain 2) (ap-mu chain family member mu1b). [swissprot;acc:q9y6q5]	551	AP1M2	Low confidence	205.768	199.453	1.03166
	1751		High confidence	221.185	223.97	1.01259
adenine phosphoribosyltransferase (ec 2.4.2.7) (aprt). [swissprot;acc:p07741]	1049	no value		211.449	217.998	1.03097
	2462		Low confidence	199.981	196.388	1.0183
adenomatous polyposis coli like. [refseq;acc:nm_005883]	161	APC2		222.34	235.547	1.0594
adenomatous polyposis coli protein (apc protein). [swissprot;acc:p25054]	160	APC		222.31	235.538	1.0595
adenosine deaminase (ec 3.5.4.4) (adenosine aminohydrolase). [swissprot;acc:p00813]	1075	no value		202.317	197.601	1.02387
adenosine kinase (ec 2.7.1.20) (ak) (adenosine 5'-phosphotransferase). [swissprot;acc:p55263]	2151	ADK		200.658	196.898	1.0191
	2563		High confidence	208.429	208.779	1.00168
adenosylhomocysteinase (ec 3.3.1.1) (s-adenosyl-l-homocysteine hydrolase) (adohcyase). [swissprot;acc:p23526]	1553	AHCY		215.389	211.833	1.01679
	1929		Low confidence	201.465	197.571	1.01971
adenovirus 5 e1a-binding protein (bs69 protein). [swissprot;acc:q15326]	2502	ZMYND11	High confidence	217.417	216.844	1.00264
	3417		Low confidence	202.077	199.041	1.01525
adenylate cyclase, type v (ec 4.6.1.1) (atp pyrophosphate-lyase) (adenylyl cyclase) (fragment). [swissprot;acc:o95622]	467	ADCY5	High confidence	248.152	267.226	1.07686
	3745		Low confidence	201.897	199.211	1.01348
adenylate cyclase, type vi (ec 4.6.1.1) (atp pyrophosphate-lyase) (ca(2+)-inhibitable adenylyl cyclase). [swissprot;acc:o43306]	466	ADCY6	High confidence	248.152	267.226	1.07686
	3744		Low confidence	201.897	199.211	1.01348
adenylate kinase isoenzyme 2, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p54819]	379	AK2	High confidence	241.509	264.163	1.0938
	3213		Low confidence	201.971	198.79	1.016
adenylate kinase isoenzyme 4, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p27144]	348	no value	High confidence	242.14	265.696	1.09728

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.