MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Network Comparison Type	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 451 to 500 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	network_comparison	green
113	PPP2CA	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	Subtracted	High confidence	194.372	39.832	234.204
	SLC11A2	natural resistance-associated macrophage protein 2 (nramp 2) (divalent metal transporter 1) (dmt1). [swissprot;acc:p49281]		Low confidence	224.763	14.197	210.566
114	B9D1	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]		High confidence	229.818	37.447	267.265
	DLGAP1	disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490]	Divided	Low confidence	197.779	1.07182	211.983
	KHDRBS1	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]		High confidence	332.874	1.24557	267.246
	MRPS17	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Subtracted	Low confidence	58	14	44
115	DLGAP4	disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0]	Divided		197.779	1.07182	211.983
	HAT1	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	Subtracted	High confidence	277.546	37.085	240.461
	KHDRBS2	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	Divided		332.874	1.24557	267.246
	SLC25A43	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Subtracted	Low confidence	58	14	44
116	no value	testican-3 precursor. [swissprot;acc:q9bq16]			220.395	13.994	234.389
	GNB3	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	Divided	High confidence	268.565	1.24545	334.483
	HMG20B	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	Subtracted		208.52	36.925	171.595
	VPS18	vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253]	Divided	Low confidence	204.161	1.07008	190.791
117	ABRA	striated muscle activator of rho-dependent signaling. [refseq;acc:nm_139166]	Subtracted		225.495	13.966	211.529
	F13A1	coagulation factor xiii a chain precursor (ec 2.3.2.13) (protein- glutamine gamma-glutamyltransferase a chain) (transglutaminase a chain). [swissprot;acc:p00488]	Divided		226.395	1.06935	211.713
	HMG20A	high-mobility group 20a. [refseq;acc:nm_018200]	Subtracted	High confidence	208.588	36.81	171.778
	NEURL	neuralized-like. [refseq;acc:nm_004210]	Divided		332.326	1.24491	266.948
118	NDUFA12	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]			284.753	1.24382	228.934
	OSR1	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	Subtracted		274.027	36.237	237.79
	SPOCK1	testican-1 precursor (spock protein). [swissprot;acc:q08629]		Low confidence	220.254	13.857	234.111
	TGM1	protein-glutamine gamma-glutamyltransferase k (ec 2.3.2.13) (transglutaminase k) (tgase k) (tgk) (tg(k)) (transglutaminase 1) (epidermal tgase). [swissprot;acc:p22735]	Divided		226.395	1.06935	211.713
119	ADIPOR2	adiponectin receptor 2. [refseq;acc:nm_024551]	Subtracted	High confidence	281.582	35.211	246.371
	NDUFS4	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]	Divided		318.982	1.23157	259.004
	SLC11A1	natural resistance-associated macrophage protein 1 (nramp 1). [swissprot;acc:p49279]		Low confidence	225.666	1.06897	211.107
	SPOCK2	testican-2 precursor. [swissprot;acc:q92563]	Subtracted		220.222	13.825	234.047
120	no value	nanos (fragment). [sptrembl;acc:q8wy41]			203.66	13.819	217.479
	DVL1	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	Divided		203.016	1.0687	189.965
	KCND2	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]		High confidence	269.278	1.21699	327.709
	TIA1	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483]	Subtracted		227.199	34.484	192.715
121	CTH	cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929]	Divided		269.254	1.2169	327.655
	DVL2	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]		Low confidence	203.007	1.06854	189.985
	TIAL1	nucleolysin tiar (tia-1 related protein). [swissprot;acc:q01085]	Subtracted	High confidence	227.202	34.379	192.823
	VPS33A	vacuolar protein sorting 33a (hvps33a). [swissprot;acc:q96ax1]		Low confidence	203.914	13.725	190.189
122	no value	nanos (fragment). [sptrembl;acc:q8wy41]	Divided		203.66	1.06785	217.479
	COPS3	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]	Subtracted	High confidence	199.949	34.238	234.187
	KCND3	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	Divided		269.248	1.21688	327.642
	VPS18	vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253]	Subtracted	Low confidence	204.161	13.37	190.791
123	DVL3	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	Divided		202.96	1.06768	190.094
	KCND1	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]		High confidence	269.23	1.21681	327.601
	SNRPD1	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641]	Subtracted		227.032	33.976	193.056
	STRN	striatin. [swissprot;acc:o43815]		Low confidence	214.085	13.289	200.796
124	DAZAP1	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]			220.268	13.271	206.997
	HMG20B	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	Divided	High confidence	208.52	1.21519	171.595
	PSEN2	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	Subtracted		285.684	33.45	252.234
	SLC11A2	natural resistance-associated macrophage protein 2 (nramp 2) (divalent metal transporter 1) (dmt1). [swissprot;acc:p49281]	Divided	Low confidence	224.763	1.06742	210.566
125	B9D1	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]			213.243	1.0674	227.616
	HMG20A	high-mobility group 20a. [refseq;acc:nm_018200]		High confidence	208.588	1.21429	171.778
	PROM1	prominin-like protein 1 precursor (antigen ac133) (cd133 antigen). [swissprot;acc:o43490]	Subtracted	Low confidence	220.268	13.271	206.997
	SKP1A	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]		High confidence	285.684	33.45	252.234

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.