MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 451 to 500 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
226	cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]	COMP	Divided	239.991	269.238	1.12187
	protein transport protein sec61 alpha subunit isoform 1 (sec61 alpha- 1). [swissprot;acc:p38378]	SEC61A1	Subtracted	242.153	266.673	24.52
227	methionine aminopeptidase 1 (ec 3.4.11.18) (metap 1) (map 1) (peptidase m 1). [swissprot;acc:p53582]	METAP1		244.126	268.604	24.478
	thrombospondin 3 precursor. [swissprot;acc:p49746]	THBS3	Divided	239.99	269.234	1.12186
228	methionine aminopeptidase 2 (ec 3.4.11.18) (metap 2) (peptidase m 2) (initiation factor 2 associated 67 kda glycoprotein) (p67) (p67eif2). [swissprot;acc:p50579]	METAP2	Subtracted	244.126	268.604	24.478
	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]	SH2D3C	Divided	226.411	202.088	1.12036
229	60s ribosomal protein l3-like. [swissprot;acc:q92901]	RPL3L	Subtracted	242.195	266.663	24.468
	breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]	BCAR3	Divided	226.401	202.094	1.12028
230	cysteine-rich protein 1 (crp1) (crp). [swissprot;acc:p21291]	CSRP1		239.35	267.915	1.11934
	protein translation factor sui1 homolog (sui1iso1). [swissprot;acc:p41567]	EIF1	Subtracted	242.694	267.017	24.323
231	likely ortholog of mouse shc sh2-domain binding protein 1. [refseq;acc:nm_024745]	SHCBP1	Divided	239.336	267.881	1.11927
	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]	SH2D3C	Subtracted	226.411	202.088	24.323
232	breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]	BCAR3		226.401	202.094	24.307
	smooth muscle cell lim protein (cysteine-rich protein 2) (crp2) (lim-only protein 5). [swissprot;acc:q16527]	CSRP2	Divided	239.336	267.879	1.11926
233	60s ribosomal protein l7. [swissprot;acc:p18124]	no value	Subtracted	235.727	259.984	24.257
	lim domain protein, cardiac (muscle lim protein) (cysteine-rich protein 3) (crp3). [swissprot;acc:p50461]	CSRP3	Divided	239.32	267.842	1.11918
234	40s ribosomal protein s23. [swissprot;acc:p39028]	RPS23	Subtracted	243.944	268.195	24.251
	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	CHRAC1	Divided	287.41	256.835	1.11905
235	28s ribosomal protein s12, mitochondrial precursor (mpr-s12) (mt- rps12). [swissprot;acc:o15235]	MRPS12	Subtracted	243.944	268.195	24.251
	phenylalanine-4-hydroxylase (ec 1.14.16.1) (pah) (phe-4- monooxygenase). [swissprot;acc:p00439]	PAH	Divided	227.357	254.15	1.11785
236	histone acetyltransferase type b subunit 2 (retinoblastoma binding protein p46) (retinoblastoma-binding protein 7) (rbbp-7). [swissprot;acc:q16576]	RBBP7	Subtracted	252.644	228.42	24.224
	pp3111 protein. [refseq;acc:nm_022156]	DUS1L	Divided	227.357	254.15	1.11785
237	mitochondrial 60s ribosomal protein l3 (l3mt). [swissprot;acc:p09001]	MRPL3	Subtracted	242.011	266.18	24.169
	syntaxin 18. [swissprot;acc:q9p2w9]	STX18	Divided	227.357	254.15	1.11785
238	metastasis-associated protein mta1. [swissprot;acc:q13330]	MTA1	Subtracted	252.512	228.356	24.156
	rd protein. [swissprot;acc:p18615]	no value	Divided	227.357	254.15	1.11785
239	dna-directed rna polymerase ii largest subunit (ec 2.7.7.6) (rpb1). [swissprot;acc:p24928]	POLR2A	Subtracted	243.817	267.962	24.145
	glutathione transferase omega 1 (ec 2.5.1.18) (gsto 1-1). [swissprot;acc:p78417]	GSTO1	Divided	227.357	254.15	1.11785
240	androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]	AIG1
	chromatin assembly factor 1 subunit c (caf-1 subunit c) (chromatin assembly factor i p48 subunit) (caf-i 48 kda subunit) (caf-ip48) (retinoblastoma binding protein p48) (retinoblastoma-binding protein 4) (rbbp-4) (msi1 protein homolog). [swissprot;acc:q09028]	RBBP4	Subtracted	252.39	228.297	24.093
241	atp synthase b chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p24539]	ATP5F1	Divided	227.357	254.15	1.11785
	epithelial-cadherin precursor (e-cadherin) (uvomorulin) (cadherin-1) (cam 120/80). [swissprot;acc:p12830]	CDH1	Subtracted	241.892	265.96	24.068
242	c367g8.3 (novel protein similar to rpl23a (60s ribosomal protein l23a)) (60s ribosomal protein l23a like). [sptrembl;acc:q9br02]	no value			265.959	24.067
	j domain containing protein 1. [swissprot;acc:q9ukb3]	DNAJC12	Divided	227.357	254.15	1.11785
243	60s ribosomal protein l23a. [swissprot;acc:p29316]	no value	Subtracted	241.884	265.945	24.061
	sorting nexin 13 (rgs domain- and phox domain-containing protein) (rgs-px1). [swissprot;acc:q9y5w8]	SNX13	Divided	227.357	254.15	1.11785
244	60s ribosomal protein l5. [swissprot;acc:p46777]	RPL5	Subtracted	241.899	265.924	24.025
	ba127l20.1 (novel glutathione-s-transferase). [sptrembl;acc:q9h4y5]	GSTO2	Divided	227.357	254.15	1.11785
245	60s ribosomal protein l19. [swissprot;acc:p14118]	RPL19	Subtracted	240.73	264.729	23.999
	small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [swissprot;acc:p43331]	SNRPD3	Divided	226.109	202.333	1.11751
246	60s ribosomal protein l12 like protein. [sptrembl;acc:o60886]	no value	Subtracted	243.583	267.528	23.945
	eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760]	EIF4G3	Divided	237.312	212.363	1.11748
247	60s ribosomal protein l12. [swissprot;acc:p30050]	no value	Subtracted	243.583	267.527	23.944
	rna-binding protein. [refseq;acc:nm_019027]		Divided	237.302	212.41	1.11719
248	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]
	dj999l4.1 (novel protein similar to ribosomal protein l12 (rpl12)). [sptrembl;acc:q9nq02]		Subtracted	243.583	267.527	23.944
249	ns1-associated protein 1. [refseq;acc:nm_006372]	SYNCRIP	Divided	237.302	212.41	1.11719
	small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [swissprot;acc:p43331]	SNRPD3	Subtracted	226.109	202.333	23.776
250	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	HNRNPR	Divided	237.302	212.41	1.11719
	pallidin; pallid (mouse) homolog, pallidin. [refseq;acc:nm_012388]	PLDN	Subtracted	210.693	186.95	23.743

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.