MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	Hugo	Value Type	description	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 451 to 500 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Network Comparison Type	Hugo	description	Interaction Map	red	network_comparison	green
113	Subtracted	PPP2CA	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]	High confidence	194.372	39.832	234.204
		SLC11A2	natural resistance-associated macrophage protein 2 (nramp 2) (divalent metal transporter 1) (dmt1). [swissprot;acc:p49281]	Low confidence	224.763	14.197	210.566
114	Divided	DLGAP1	disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490]		197.779	1.07182	211.983
		KHDRBS1	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	High confidence	332.874	1.24557	267.246
	Subtracted	B9D1	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]		229.818	37.447	267.265
		MRPS17	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Low confidence	58	14	44
115	Divided	DLGAP4	disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0]		197.779	1.07182	211.983
		KHDRBS2	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	High confidence	332.874	1.24557	267.246
	Subtracted	HAT1	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]		277.546	37.085	240.461
		SLC25A43	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Low confidence	58	14	44
116	Divided	GNB3	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	High confidence	268.565	1.24545	334.483
		VPS18	vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253]	Low confidence	204.161	1.07008	190.791
	Subtracted	no value	testican-3 precursor. [swissprot;acc:q9bq16]		220.395	13.994	234.389
		HMG20B	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	High confidence	208.52	36.925	171.595
117	Divided	F13A1	coagulation factor xiii a chain precursor (ec 2.3.2.13) (protein- glutamine gamma-glutamyltransferase a chain) (transglutaminase a chain). [swissprot;acc:p00488]	Low confidence	226.395	1.06935	211.713
		NEURL	neuralized-like. [refseq;acc:nm_004210]	High confidence	332.326	1.24491	266.948
	Subtracted	ABRA	striated muscle activator of rho-dependent signaling. [refseq;acc:nm_139166]	Low confidence	225.495	13.966	211.529
		HMG20A	high-mobility group 20a. [refseq;acc:nm_018200]	High confidence	208.588	36.81	171.778
118	Divided	NDUFA12	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]		284.753	1.24382	228.934
		TGM1	protein-glutamine gamma-glutamyltransferase k (ec 2.3.2.13) (transglutaminase k) (tgase k) (tgk) (tg(k)) (transglutaminase 1) (epidermal tgase). [swissprot;acc:p22735]	Low confidence	226.395	1.06935	211.713
	Subtracted	OSR1	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	High confidence	274.027	36.237	237.79
		SPOCK1	testican-1 precursor (spock protein). [swissprot;acc:q08629]	Low confidence	220.254	13.857	234.111
119	Divided	NDUFS4	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]	High confidence	318.982	1.23157	259.004
		SLC11A1	natural resistance-associated macrophage protein 1 (nramp 1). [swissprot;acc:p49279]	Low confidence	225.666	1.06897	211.107
	Subtracted	ADIPOR2	adiponectin receptor 2. [refseq;acc:nm_024551]	High confidence	281.582	35.211	246.371
		SPOCK2	testican-2 precursor. [swissprot;acc:q92563]	Low confidence	220.222	13.825	234.047
120	Divided	DVL1	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]		203.016	1.0687	189.965
		KCND2	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	High confidence	269.278	1.21699	327.709
	Subtracted	no value	nanos (fragment). [sptrembl;acc:q8wy41]	Low confidence	203.66	13.819	217.479
		TIA1	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483]	High confidence	227.199	34.484	192.715
121	Divided	CTH	cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929]		269.254	1.2169	327.655
		DVL2	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	Low confidence	203.007	1.06854	189.985
	Subtracted	TIAL1	nucleolysin tiar (tia-1 related protein). [swissprot;acc:q01085]	High confidence	227.202	34.379	192.823
		VPS33A	vacuolar protein sorting 33a (hvps33a). [swissprot;acc:q96ax1]	Low confidence	203.914	13.725	190.189
122	Divided	no value	nanos (fragment). [sptrembl;acc:q8wy41]		203.66	1.06785	217.479
		KCND3	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	High confidence	269.248	1.21688	327.642
	Subtracted	COPS3	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]		199.949	34.238	234.187
		VPS18	vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253]	Low confidence	204.161	13.37	190.791
123	Divided	DVL3	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]		202.96	1.06768	190.094
		KCND1	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]	High confidence	269.23	1.21681	327.601
	Subtracted	SNRPD1	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641]		227.032	33.976	193.056
		STRN	striatin. [swissprot;acc:o43815]	Low confidence	214.085	13.289	200.796
124	Divided	HMG20B	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	High confidence	208.52	1.21519	171.595
		SLC11A2	natural resistance-associated macrophage protein 2 (nramp 2) (divalent metal transporter 1) (dmt1). [swissprot;acc:p49281]	Low confidence	224.763	1.06742	210.566
	Subtracted	DAZAP1	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]		220.268	13.271	206.997
		PSEN2	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	High confidence	285.684	33.45	252.234
125	Divided	B9D1	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]	Low confidence	213.243	1.0674	227.616
		HMG20A	high-mobility group 20a. [refseq;acc:nm_018200]	High confidence	208.588	1.21429	171.778
	Subtracted	PROM1	prominin-like protein 1 precursor (antigen ac133) (cd133 antigen). [swissprot;acc:o43490]	Low confidence	220.268	13.271	206.997
		SKP1A	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	High confidence	285.684	33.45	252.234

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.