MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Network Comparison Type	Hugo	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 451 to 500 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	Hugo	Value Type	red	network_comparison	green
57	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]	Divided	KHDRBS3	Measured	1631.67	1.63302	2664.55
	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]		MAGEA11	Squared	219048	1.68808	129762
	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Subtracted	no value	Rooted	137.446	16.623	120.823
	myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]		MYO15A	Ranked	185.678	59.569	245.247
	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	Divided	KCND3	Rooted	41.6879	1.43973	28.9554
	ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157]	Subtracted	RRAGC	Measured	20911	3997.5	24908.5
58	glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]		PYGM	Ranked	185.678	59.569	245.247
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	Divided	GNG4		266.863	1.25979	336.191
	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]		KHDRBS1	Measured	1631.67	1.63302	2664.55
	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]		MAGEA2B	Squared	219048	1.68808	129762
	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Subtracted	MAGEA9	Rooted	137.446	16.623	120.823
	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]	Divided	KCND1		41.6969	1.43933	28.9696
	ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064]	Subtracted	RRAGB	Measured	20911	3997.5	24908.5
	retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246]		HSD17B14	Squared	173408	69581	242989
59	anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]		ANLN	Measured	20911	3997.5	24908.5
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	Divided	GNG3	Ranked	266.863	1.25978	336.19
	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]		no value	Squared	219048	1.68808	129762
	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]		KHDRBS2	Measured	1631.67	1.63302	2664.55
	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Subtracted	MAGEA8	Rooted	137.446	16.623	120.823
	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	Divided	NDUFA12		37.2205	1.40262	52.2064
	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	Subtracted	KCND2	Ranked	269.278	58.431	327.709
	serine/threonine protein phosphatase pp1-gamma catalytic subunit (ec 3.1.3.16) (pp-1g). [swissprot;acc:p36873]		PPP1CC	Squared	199594	69573	130021
60	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	Divided	GBE1	Measured	4489.19	1.6231	2765.82
	cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929]	Subtracted	CTH	Ranked	269.254	58.401	327.655
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	Divided	GNG8		266.864	1.25976	336.184
	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]		MAGEA6	Squared	219048	1.68808	129762
	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Subtracted	MAGEC1	Rooted	137.446	16.623	120.823
	protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236]		PPP1R2	Squared	192904	66737	126167
	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	Divided	SON	Rooted	35.6294	1.39806	49.8119
	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	Subtracted	no value	Measured	16771.5	3882.4	12889.1
61	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]		ARRB2		6475.5	3832	10307.5
	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	Divided	PYGB		4489.19	1.6231	2765.82
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]		GNG5	Ranked	266.864	1.25975	336.182
	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]		KCNIP1	Rooted	43.4291	1.36932	31.7159
	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	Subtracted	MAGEA4		137.446	16.623	120.823
	necdin. [swissprot;acc:q99608]	Divided	NDN	Squared	219048	1.68808	129762
	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	Subtracted	KCND3	Ranked	269.248	58.394	327.642
	type 1 protein phosphatase inhibitor. [refseq;acc:nm_025210]		PPP1R2P9	Squared	192779	66684	126095
62	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]		ARRB1	Measured	6475.5	3832	10307.5
	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]	Divided	PYGL		4489.19	1.6231	2765.82
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]		GNG10	Ranked	266.865	1.25974	336.181
	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	Subtracted	no value	Rooted	137.446	16.623	120.823
	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Divided	MAGED1	Squared	219048	1.68808	129762
	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]		KCNIP4	Rooted	43.4519	1.36847	31.7522
	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]	Subtracted	KCND1	Ranked	269.23	58.371	327.601
	ribosome biogenesis regulatory protein homolog. [swissprot;acc:q15050]		RRS1	Squared	189976	65496	124480
63	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	Divided	no value	Ranked	266.865	1.25973	336.178
	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]		KCNIP2	Rooted	43.4554	1.36835	31.7576
	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	Subtracted	MAGEA10		137.446	16.623	120.823
	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Divided	MAGEF1	Squared	219048	1.68808	129762

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.