MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Value Type	Gene	description	Network Comparison Type	Filtered	Interaction Map	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 4491 to 4540 of 12912 in total

Network Comparison Type  : Divided
Filtered  : 1
Interaction Map  : High confidence

Rank	Value Type	description	red	green	network_comparison
1123	Squared	hskin17 protein. [refseq;acc:nm_012311]	25154	28740.5	1.14258
	Rooted	casein kinase i, alpha isoform (ec 2.7.1.-) (cki-alpha) (ck1). [swissprot;acc:p48729]	57.0994	59.9007	1.04906
1124	Measured	transducin-like enhancer protein 2 (esg2). [swissprot;acc:q04725]	6288.27	6846.97	1.08885
	Ranked	peroxiredoxin 5, mitochondrial precursor (prx-v) (peroxisomal antioxidant enzyme) (plp) (thioredoxin peroxidase pmp20) (antioxidant enzyme b166) (aoeb166) (tpx type vi) (liver tissue 2d-page spot 71b) (alu co-repressor 1) (sbbi10). [swissprot;acc:p30044]	207.553	213.256	1.02748
	Squared	carnitine o-acetyltransferase (ec 2.3.1.7) (carnitine acetylase) (cat). [swissprot;acc:p43155]	25154	28740.5	1.14258
	Rooted	putative phosphoglycerate mutase 3 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13). [swissprot;acc:q8n0y7]	63.5285	66.6395	1.04897
1125	Measured	transducin-like enhancer protein 1 (esg1). [swissprot;acc:q04724]	6287.07	6845.28	1.08879
	Ranked	dj718p11.1.2 (novel class ii aminotransferase similar to serine palmotyltransferase (isoform 2)) (fragment). [sptrembl;acc:q9ugb5]	204.404	210.022	1.02748
	Squared	polyadenylate-binding protein 4 (poly(a)-binding protein 4) (pabp 4) (inducible poly(a)-binding protein) (ipabp) (activated-platelet protein-1) (app-1). [swissprot;acc:q13310]	25154	28740.5	1.14258
	Rooted	phosphoglycerate mutase 1 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme b) (pgam-b) (bpg-dependent pgam 1). [swissprot;acc:p18669]	63.5285	66.6395	1.04897
1126	Measured	importin alpha-6 subunit (karyopherin alpha-5 subunit). [swissprot;acc:o15131]	5792.08	6305.67	1.08867
	Ranked	atpase, h+ transporting, lysosomal 38kda, v0 subunit d isoform 2. [refseq;acc:nm_152565]	218.487	212.656	1.02742
	Squared	polyadenylate-binding protein 1 (poly(a)-binding protein 1) (pabp 1). [swissprot;acc:p11940]	25154	28740.5	1.14258
	Rooted	phosphoglycerate mutase 2 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme m) (pgam-m) (bpg-dependent pgam 2) (muscle-specific phosphoglycerate mutase). [swissprot;acc:p15259]	63.5285	66.6395	1.04897
1127	Measured	yip1 interacting factor homolog; yip1p-interacting factor; putative rab5-interacting protein; putative transmembrane protein 54tmp. [refseq;acc:nm_020470]	5790.65	6303.92	1.08864
	Ranked	nucleolar protein nop5 (nucleolar protein 5) (nop58) (hspc120). [swissprot;acc:q9y2x3]	239.219	232.837	1.02741
	Squared	60s ribosomal protein l39. [swissprot;acc:p02404]	18854.4	21540.4	1.14246
	Rooted	limbic system-associated membrane protein precursor (lsamp). [swissprot;acc:q13449]	59.7501	62.6744	1.04894
1128	Measured	voltage-gated potassium channel beta-3 subunit (k+ channel beta-3 subunit) (kv-beta-3). [swissprot;acc:o43448]	5790.65	6303.94	1.08864
	Ranked	homeobox protein six1 (sine oculis homeobox homolog 1). [swissprot;acc:q15475]	221.286	215.399	1.02733
	Squared	60s ribosomal protein l18a. [swissprot;acc:q02543]	18854.4	21540.4	1.14246
	Rooted	60s ribosomal protein l24 (l30). [swissprot;acc:p38663]	69.8977	73.3177	1.04893
1129	Measured	voltage-gated potassium channel beta-1 subunit (k+ channel beta-1 subunit) (kv-beta-1). [swissprot;acc:q14722]	5790.65	6303.92	1.08864
	Ranked	homeobox protein six2 (sine oculis homeobox homolog 2). [swissprot;acc:q9npc8]	221.285	215.401	1.02732
	Squared	40s ribosomal protein s19. [swissprot;acc:p39019]	18854.4	21540.4	1.14246
	Rooted	similar to ecotropic viral integration site 5; neuroblastoma stage 4s gene. [refseq;acc:nm_145245]	61.8294	64.8484	1.04883
1130	Measured	similar to putative transmembrane protein; homolog of yeast golgi membrane protein yif1p (yip1p-interacting factor). [refseq;acc:nm_033557]	5790.65	6303.92	1.08864
	Ranked	proliferation-associated protein 2g4 (cell cycle protein p38-2g4 homolog) (hg4-1). [swissprot;acc:q9uq80]	221.285	215.4	1.02732
	Squared	60s ribosomal protein l31. [swissprot;acc:p12947]	18854.4	21540.4	1.14246
	Rooted	ecotropic viral integration site 5; neuroblastoma stage 4s gene. [refseq;acc:nm_005665]	61.8294	64.8484	1.04883
1131	Measured	aflatoxin b1 aldehyde reductase 2 (ec 1.-.-.-) (afb1-ar 2). [swissprot;acc:o95154]	5790.65	6303.92	1.08864
	Ranked	vacuolar atp synthase subunit g 2 (ec 3.6.3.14) (v-atpase g subunit 2) (vacuolar proton pump g subunit 2) (v-atpase 13 kda subunit 2). [swissprot;acc:o95670]	218.484	212.675	1.02731
	Squared	casein kinase i, delta isoform (ec 2.7.1.-) (cki-delta) (ckid). [swissprot;acc:p48730]	20739	23691.8	1.14238
	Rooted	dna-directed rna polymerases i, ii, and iii 17.1 kda polypeptide (ec 2.7.7.6) (rpb17) (rpb8) (rpabc3). [swissprot;acc:p52434]	53.3231	50.8416	1.04881
1132	Measured	alpha/beta hydrolase domain containing protein 3; lung alpha/beta hydrolase 3. [refseq;acc:nm_138340]	5790.65	6303.92	1.08864
	Ranked	apoptosis inhibitor 5; fibroblast growth factor 2-interacting factor 2; api5-like 1. [refseq;acc:nm_006595]	218.484	212.675	1.02731
	Squared	casein kinase i, epsilon isoform (ec 2.7.1.-) (cki-epsilon) (ckie). [swissprot;acc:p49674]	20709.5	23652.8	1.14212
	Rooted	transformer-2 protein homolog (tra-2 alpha). [swissprot;acc:q13595]	64.7804	67.9395	1.04877
1133	Measured	golgi membrane protein sb140; smooth muscle cell associated protein 5. [refseq;acc:nm_030799]	5790.65	6303.92	1.08864
	Ranked	sec13-related protein. [swissprot;acc:p55735]	218.484	212.675	1.02731
	Squared	g1 to s phase transition protein 1 homolog (gtp-binding protein gst1-hs). [swissprot;acc:p15170]	29990.9	34251.1	1.14205
	Rooted	protein cgi-27 (c21orf19-like protein). [swissprot;acc:q9y316]	53.091	50.6263	1.04868
1134	Measured	alpha/beta hydrolase domain containing protein 1 isoform 2; lung alpha/beta hydrolase protein 1. [refseq;acc:nm_152870]	5790.65	6303.92	1.08864
	Ranked	vacuolar atp synthase subunit g 3 (ec 3.6.3.14) (v-atpase g subunit 3) (vacuolar proton pump g subunit 3) (v-atpase 13 kda subunit 3). [swissprot;acc:q96lb4]	218.484	212.675	1.02731
	Squared	u3 snornp protein 4 homolog. [refseq;acc:nm_033416]	17170.9	19604	1.1417
	Rooted	arginine/serine-rich splicing factor 10 (transformer-2-beta) (htra2- beta) (transformer 2 protein homolog) (silica-induced protein 41) (ra301). [swissprot;acc:q15815]	64.9094	68.0692	1.04868
1135	Measured	methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial precursor (ec 1.2.1.27) (mmsdh). [swissprot;acc:q02252]	5790.67	6303.95	1.08864
	Ranked	vacuolar atp synthase subunit b, brain isoform (ec 3.6.3.14) (v-atpase b2 subunit) (vacuolar proton pump b isoform 2) (endomembrane proton pump 58 kda subunit) (ho57). [swissprot;acc:p21281]	218.484	212.675	1.02731
	Squared	14-3-3 protein zeta/delta (protein kinase c inhibitor protein-1) (kcip-1) (factor activating exoenzyme s) (fas). [swissprot;acc:p29312]	28600.9	32641.7	1.14128
	Rooted	opioid binding protein/cell adhesion molecule precursor (obcam) (opioid-binding cell adhesion molecule) (opcml). [swissprot;acc:q14982]	59.8204	62.7321	1.04867

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.