MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 430 to 479 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	network_comparison	green
215	EIF4G1	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	Subtracted	237.292	24.835	212.457
216	MYH4	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]	Divided	112	1.125	126
	SNRPD2	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	Subtracted	226.471	24.702	201.769
217	MYH8	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]	Divided	112	1.125	126
	RPL26	60s ribosomal protein l26. [swissprot;acc:q02877]	Subtracted	242.326	24.682	267.008
218	MYH2	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	Divided	112	1.125	126
	RPL35	60s ribosomal protein l35. [swissprot;acc:p42766]	Subtracted	242.333	24.666	266.999
219	no value	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]		242.339	24.647	266.986
	MYH3	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	Divided	112	1.125	126
220	MRPL2	mitochondrial ribosomal protein l2. [refseq;acc:nm_015950]	Subtracted	242.339	24.647	266.986
	MYH1	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	Divided	112	1.125	126
221	no value	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]
	EIF1B	protein translation factor sui1 homolog gc20. [swissprot;acc:o60739]	Subtracted	242.627	24.524	267.151
222	no value	60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]		242.153	24.52	266.673
	MYH7B	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	Divided	112	1.125	126
223	MYH13	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]
	SRR	serine racemase (ec 5.1.1.-). [swissprot;acc:q9gzt4]	Subtracted	242.153	24.52	266.673
224	RPL34	60s ribosomal protein l34. [swissprot;acc:p49207]
	SLC15A2	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]	Divided	185.969	1.12285	165.623
225	SEC61A2	protein transport protein sec61 alpha subunit isoform 2 (sec61 alpha- 2). [swissprot;acc:q9y2r3]	Subtracted	242.153	24.52	266.673
	SNRPD2	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	Divided	226.471	1.12243	201.769
226	COMP	cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]		239.991	1.12187	269.238
	SEC61A1	protein transport protein sec61 alpha subunit isoform 1 (sec61 alpha- 1). [swissprot;acc:p38378]	Subtracted	242.153	24.52	266.673
227	METAP1	methionine aminopeptidase 1 (ec 3.4.11.18) (metap 1) (map 1) (peptidase m 1). [swissprot;acc:p53582]		244.126	24.478	268.604
	THBS3	thrombospondin 3 precursor. [swissprot;acc:p49746]	Divided	239.99	1.12186	269.234
228	METAP2	methionine aminopeptidase 2 (ec 3.4.11.18) (metap 2) (peptidase m 2) (initiation factor 2 associated 67 kda glycoprotein) (p67) (p67eif2). [swissprot;acc:p50579]	Subtracted	244.126	24.478	268.604
	SH2D3C	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]	Divided	226.411	1.12036	202.088
229	BCAR3	breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]		226.401	1.12028	202.094
	RPL3L	60s ribosomal protein l3-like. [swissprot;acc:q92901]	Subtracted	242.195	24.468	266.663
230	CSRP1	cysteine-rich protein 1 (crp1) (crp). [swissprot;acc:p21291]	Divided	239.35	1.11934	267.915
	EIF1	protein translation factor sui1 homolog (sui1iso1). [swissprot;acc:p41567]	Subtracted	242.694	24.323	267.017
231	SH2D3C	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]		226.411		202.088
	SHCBP1	likely ortholog of mouse shc sh2-domain binding protein 1. [refseq;acc:nm_024745]	Divided	239.336	1.11927	267.881
232	BCAR3	breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]	Subtracted	226.401	24.307	202.094
	CSRP2	smooth muscle cell lim protein (cysteine-rich protein 2) (crp2) (lim-only protein 5). [swissprot;acc:q16527]	Divided	239.336	1.11926	267.879
233	no value	60s ribosomal protein l7. [swissprot;acc:p18124]	Subtracted	235.727	24.257	259.984
	CSRP3	lim domain protein, cardiac (muscle lim protein) (cysteine-rich protein 3) (crp3). [swissprot;acc:p50461]	Divided	239.32	1.11918	267.842
234	CHRAC1	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]		287.41	1.11905	256.835
	RPS23	40s ribosomal protein s23. [swissprot;acc:p39028]	Subtracted	243.944	24.251	268.195
235	MRPS12	28s ribosomal protein s12, mitochondrial precursor (mpr-s12) (mt- rps12). [swissprot;acc:o15235]
	PAH	phenylalanine-4-hydroxylase (ec 1.14.16.1) (pah) (phe-4- monooxygenase). [swissprot;acc:p00439]	Divided	227.357	1.11785	254.15
236	DUS1L	pp3111 protein. [refseq;acc:nm_022156]
	RBBP7	histone acetyltransferase type b subunit 2 (retinoblastoma binding protein p46) (retinoblastoma-binding protein 7) (rbbp-7). [swissprot;acc:q16576]	Subtracted	252.644	24.224	228.42
237	MRPL3	mitochondrial 60s ribosomal protein l3 (l3mt). [swissprot;acc:p09001]		242.011	24.169	266.18
	STX18	syntaxin 18. [swissprot;acc:q9p2w9]	Divided	227.357	1.11785	254.15
238	no value	rd protein. [swissprot;acc:p18615]
	MTA1	metastasis-associated protein mta1. [swissprot;acc:q13330]	Subtracted	252.512	24.156	228.356
239	GSTO1	glutathione transferase omega 1 (ec 2.5.1.18) (gsto 1-1). [swissprot;acc:p78417]	Divided	227.357	1.11785	254.15
	POLR2A	dna-directed rna polymerase ii largest subunit (ec 2.7.7.6) (rpb1). [swissprot;acc:p24928]	Subtracted	243.817	24.145	267.962
240	AIG1	androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]	Divided	227.357	1.11785	254.15

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.