MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 425 to 474 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
213	FMO4	dimethylaniline monooxygenase [n-oxide forming] 4 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 4) (fmo 4) (dimethylaniline oxidase 4). [swissprot;acc:p31512]	Low confidence	209.765	199.755	1.05011
	PLDN	pallidin; pallid (mouse) homolog, pallidin. [refseq;acc:nm_012388]	High confidence	210.693	186.95	1.127
214	LASS2	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]		191.644	170.192	1.12605
	OGT	udp-n-acetylglucosamine--peptide n-acetylglucosaminyltransferase 110 kda subunit (ec 2.4.1.-) (o-glcnac transferase p110 subunit). [swissprot;acc:o15294]	Low confidence	206.583	196.743	1.05001
215	no value	myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533]	High confidence	112	126	1.125
	NEGR1	a kindred of iglon. [refseq;acc:nm_173808]	Low confidence	199.671	209.654	1.05
216	MYH4	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]	High confidence	112	126	1.125
	NMBR	neuromedin-b receptor (nmb-r) (neuromedin-b-preferring bombesin receptor). [swissprot;acc:p28336]	Low confidence	199.671	209.654	1.05
217	GRPR	gastrin-releasing peptide receptor (grp-r) (grp-preferring bombesin receptor). [swissprot;acc:p30550]
	MYH8	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]	High confidence	112	126	1.125
218	BRS3	bombesin receptor subtype-3 (brs-3). [swissprot;acc:p32247]	Low confidence	199.671	209.654	1.05
	MYH2	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	High confidence	112	126	1.125
219	BACH1	transcription regulator protein bach1 (btb and cnc homolog 1) (ha2303). [swissprot;acc:o14867]	Low confidence	172.647	164.44	1.04991
	MYH3	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	High confidence	112	126	1.125
220	MYH1	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]
	NFE2L2	nuclear factor erythroid 2 related factor 2 (nf-e2 related factor 2) (nfe2-related factor 2) (nuclear factor, erythroid derived 2, like 2) (hebp1). [swissprot;acc:q16236]	Low confidence	172.647	164.44	1.04991
221	no value	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]	High confidence	112	126	1.125
	BACH2	transcription regulator protein bach2 (btb and cnc homolog 2). [swissprot;acc:q9byv9]	Low confidence	172.647	164.44	1.04991
222	MYH7B	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	High confidence	112	126	1.125
	UBE2E1	ubiquitin-conjugating enzyme e2 e1 (ec 6.3.2.19) (ubiquitin-protein ligase e1) (ubiquitin carrier protein e1) (ubch6). [swissprot;acc:p51965]	Low confidence	203.935	214.089	1.04979
223	GTF3C3	general transcription factor iiic, polypeptide 3, 102kda; general transcription factor iiic, polypeptide 3 (102kd); transcription factor iiic, 102 kd. [refseq;acc:nm_012086]		217.228	206.926
	MYH13	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]	High confidence	112	126	1.125
224	SLC15A2	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]		185.969	165.623	1.12285
	UBE2E4P	ubiquitin-conjugating enzyme e2e 3; ubiquitin carrier protein; ubiquitin-protein ligase. [refseq;acc:nm_006357]	Low confidence	203.933	214.059	1.04965
225	SLC15A1	oligopeptide transporter, small intestine isoform (peptide transporter 1) (intestinal h+/peptide cotransporter) (solute carrier family 15, member 1). [swissprot;acc:p46059]		201.41	191.974	1.04915
	SNRPD2	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	High confidence	226.471	201.769	1.12243
226	COMP	cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]		239.991	269.238	1.12187
	LEF1	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]	Low confidence	208.289	198.538	1.04911
227	TENC1	c1 domain-containing phosphatase and tensin-like protein isoform 2; putative protein tyrosine phosphatase; c1 domain-containing phosphatase and tensin-like protein; tensin 2. [refseq;acc:nm_015319]		216.404	206.277	1.04909
	THBS3	thrombospondin 3 precursor. [swissprot;acc:p49746]	High confidence	239.99	269.234	1.12186
228	SH2D3C	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]		226.411	202.088	1.12036
	SNRPA	u1 small nuclear ribonucleoprotein a (u1 snrnp a protein). [swissprot;acc:p09012]	Low confidence	202.727	193.31	1.04871
229	BCAR3	breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]	High confidence	226.401	202.094	1.12028
	TLR2	toll-like receptor 2 precursor (toll/interleukin 1 receptor-like protein 4). [swissprot;acc:o60603]	Low confidence	207.926	198.276	1.04867
230	CCDC22	jm1 protein. [refseq;acc:nm_014008]		216.308	206.292	1.04855
	CSRP1	cysteine-rich protein 1 (crp1) (crp). [swissprot;acc:p21291]	High confidence	239.35	267.915	1.11934
231	SHCBP1	likely ortholog of mouse shc sh2-domain binding protein 1. [refseq;acc:nm_024745]		239.336	267.881	1.11927
	TIMM23	mitochondrial import inner membrane translocase subunit tim23. [swissprot;acc:o14925]	Low confidence	220.722	210.645	1.04784
232	CSRP2	smooth muscle cell lim protein (cysteine-rich protein 2) (crp2) (lim-only protein 5). [swissprot;acc:q16527]	High confidence	239.336	267.879	1.11926
	NFYA	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	Low confidence	214.032	204.284	1.04772
233	CSRP3	lim domain protein, cardiac (muscle lim protein) (cysteine-rich protein 3) (crp3). [swissprot;acc:p50461]	High confidence	239.32	267.842	1.11918
	NFYC	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]	Low confidence	209.649	200.129	1.04757
234	CHRAC1	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	High confidence	287.41	256.835	1.11905
	CYP51A1	cytochrome p450 51a1 (ec 1.14.13.70) (cypli) (p450li) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (ldm) (p450-14dm). [swissprot;acc:q16850]	Low confidence	208.851	199.38	1.0475
235	PAH	phenylalanine-4-hydroxylase (ec 1.14.16.1) (pah) (phe-4- monooxygenase). [swissprot;acc:p00439]	High confidence	227.357	254.15	1.11785
	SNRPB2	u2 small nuclear ribonucleoprotein b". [swissprot;acc:p08579]	Low confidence	202.654	193.53	1.04715
236	CASK	peripheral plasma membrane protein cask (ec 2.7.1.-) (hcask) (calcium/calmodulin-dependent serine protein kinase) (lin-2 homolog). [swissprot;acc:o14936]		212.056	202.524	1.04707
	DUS1L	pp3111 protein. [refseq;acc:nm_022156]	High confidence	227.357	254.15	1.11785
237	SIM1	single-minded homolog 1. [swissprot;acc:p81133]	Low confidence	212.056	202.524	1.04707
	STX18	syntaxin 18. [swissprot;acc:q9p2w9]	High confidence	227.357	254.15	1.11785

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.