MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Rank	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 412 to 461 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	Value Type	red	green	network_comparison
3-hydroxyacyl-coa dehydrogenase type ii (ec 1.1.1.35) (type ii hadh) (endoplasmic reticulum-associated amyloid beta-peptide binding protein) (short-chain type dehydrogenase/reductase xh98g2). [swissprot;acc:q99714]	3180	HSD17B10	Divided	Rooted	0.00001	0.00001	1
			Subtracted	Measured	0	0	0
				Ranked
				Squared
				Rooted
3-hydroxyanthranilate 3,4-dioxygenase (ec 1.13.11.6) (3-hao) (3-hydroxyanthranilic acid dioxygenase) (3-hydroxyanthranilate oxygenase). [swissprot;acc:p46952]	1664	HAAO			67.2158	69.3348	2.119
	1764		Divided				1.03153
	1826		Subtracted	Measured	6916.14	7295.24	379.1
	2105		Divided				1.05481
	2189			Ranked	209.54	208.162	1.00662
	2201		Subtracted				1.378
	2541			Squared	35558.6	36579.1	1020.5
	2642		Divided				1.0287
3-hydroxyisobutyryl-coenzyme a hydrolase. [refseq;acc:nm_014362]	544	no value	Subtracted		27898	32866.2	4968.2
	646		Divided				1.17808
	1543		Subtracted	Measured	6885.11	7317.48	432.37
	1852		Divided	Ranked	196.008	198.154	1.01095
	1898			Measured	6885.11	7317.48	1.0628
	1914		Subtracted	Ranked	196.008	198.154	2.146
	2369			Rooted	70.3295	71.371	1.0415
	2412		Divided				1.01481
3-ketoacyl-coa thiolase, peroxisomal precursor (ec 2.3.1.16) (beta- ketothiolase) (acetyl-coa acyltransferase) (peroxisomal 3-oxoacyl- coa thiolase). [swissprot;acc:p09110]	840	ACAA1	Subtracted	Squared	27235.1	31125.2	3890.1
	1116		Divided				1.14283
	2061		Subtracted	Measured	6946.82	7263.87	317.05
	2300		Divided	Ranked	191.563	192.541	1.00511
	2305			Measured	6946.82	7263.87	1.04564
	2331		Subtracted	Ranked	191.563	192.541	0.978
	2473			Rooted	71.4427	72.2607	0.818
	2490		Divided				1.01145
3-mercaptopyruvate sulfurtransferase (ec 2.8.1.2) (mst). [swissprot;acc:p25325]	515	MPST		Squared	19987.6	23960.7	1.19878
	563			Measured	5480.24	6222.04	1.13536
	615		Subtracted				741.8
	767		Divided	Rooted	63.5181	67.7402	1.06647
	769		Subtracted				4.2221
	805			Squared	19987.6	23960.7	3973.1
	1025		Divided	Ranked	205.632	199.266	1.03195
	1048		Subtracted				6.366
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]	959	SRD5A1		Rooted	61.6649	65.1892	3.5243
	971		Divided				1.05715
	1040		Subtracted	Ranked	220.118	213.685	6.433
	1083		Divided				1.03011
	1244		Subtracted	Measured	5885	6371.14	486.14
	1274		Divided				1.08261
	2526		Subtracted	Squared	28935	30015.7	1080.7
	2609		Divided				1.03735
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213]	960	SRD5A2	Subtracted	Rooted	61.6649	65.1892	3.5243
	972		Divided				1.05715
	1041		Subtracted	Ranked	220.118	213.685	6.433
	1084		Divided				1.03011
	1245		Subtracted	Measured	5885	6371.14	486.14

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.