MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	Hugo	Value Type	description	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 412 to 461 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Network Comparison Type	Hugo	description	Interaction Map	red	network_comparison	green
103	Subtracted	JUNB	transcription factor jun-b. [swissprot;acc:p17275]	High confidence	201.144	42.276	158.868
104	Divided	ADIPOR2	adiponectin receptor 2. [refseq;acc:nm_024551]	Low confidence	219.277	1.07377	204.212
		HOMER2	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]	High confidence	252.371	1.24926	202.016
	Subtracted	SLC11A1	natural resistance-associated macrophage protein 1 (nramp 1). [swissprot;acc:p49279]	Low confidence	225.666	14.559	211.107
		TARDBP	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	High confidence	256.228	42.21	298.438
105	Divided	E2F1	transcription factor e2f1 (e2f-1) (retinoblastoma binding protein 3) (rbbp-3) (prb-binding protein e2f-1) (pbr3) (retinoblastoma-associated protein 1) (rbap-1). [swissprot;acc:q01094]	Low confidence	220.497	1.07369	205.364
		GNB1	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	High confidence	266.716	1.24914	333.165
	Subtracted	B9D1	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]	Low confidence	213.243	14.373	227.616
		JUND	transcription factor jun-d. [swissprot;acc:p17535]	High confidence	200.941	42	158.941
106	Divided	COQ7	ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807]		252.329	1.24913	202.004
		E2F2	transcription factor e2f2 (e2f-2). [swissprot;acc:q14209]	Low confidence	220.497	1.07369	205.364
	Subtracted	DLGAP3	disks large-associated protein 3 (dap-3) (sap90/psd-95-associated protein 3) (sapap3) (psd-95/sap90 binding protein 3) (fragment). [swissprot;acc:o95886]		197.731	14.338	212.069
		NOSTRIN	nostrin. [refseq;acc:nm_052946]	High confidence	209.299	39.888	249.187
107	Divided	FAM89B	mouse mammary turmor virus receptor homolog 1. [refseq;acc:nm_152832]	Low confidence	227.429	1.07293	211.97
		HOMER1	homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]	High confidence	252.309	1.24907	201.998
	Subtracted	PTPRA	vacuolar protein sorting 16 (hvps16). [swissprot;acc:q9h269]	Low confidence	203.948	14.296	189.652
		SNF8	eap30 subunit of ell complex. [refseq;acc:nm_007241]	High confidence	209.299	39.888	249.187
108	Divided	DLGAP3	disks large-associated protein 3 (dap-3) (sap90/psd-95-associated protein 3) (sapap3) (psd-95/sap90 binding protein 3) (fragment). [swissprot;acc:o95886]	Low confidence	197.731	1.07251	212.069
		HOMER3	homer, neuronal immediate early gene, 3. [refseq;acc:nm_004838]	High confidence	252.296	1.24902	201.995
	Subtracted	no value	disks large-associated protein 2 (dap-2) (sap90/psd-95-associated protein 2) (sapap2) (psd-95/sap90 binding protein 2) (fragment). [swissprot;acc:q9p1a6]	Low confidence	197.752	14.279	212.031
		SLC39A6	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	High confidence	209.299	39.888	249.187
109	Divided	GNB4	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]		266.933	1.24856	333.281
		NEURL	neuralized-like. [refseq;acc:nm_004210]	Low confidence	232.704	1.07239	216.996
	Subtracted	CREG1	cellular repressor of e1a-stimulated genes. [refseq;acc:nm_003851]		197.762	14.251	212.013
		GAD2	glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]	High confidence	209.299	39.888	249.187
110	Divided	no value	disks large-associated protein 2 (dap-2) (sap90/psd-95-associated protein 2) (sapap2) (psd-95/sap90 binding protein 2) (fragment). [swissprot;acc:q9p1a6]	Low confidence	197.752	1.07221	212.031
		DTX2	deltex 2. [refseq;acc:nm_020892]	High confidence	333.144	1.2459	267.393
	Subtracted	CREG2	cellular repressor of e1a-stimulated genes 2. [refseq;acc:nm_153836]	Low confidence	197.763	14.248	212.011
		NAPG	gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [swissprot;acc:q99747]	High confidence	209.299	39.888	249.187
111	Divided	DTX1	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]		332.925	1.24563	267.274
		VPS33A	vacuolar protein sorting 33a (hvps33a). [swissprot;acc:q96ax1]	Low confidence	203.914	1.07217	190.189
	Subtracted	DLGAP1	disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490]		197.779	14.204	211.983
		GAD1	glutamate decarboxylase, 67 kda isoform (ec 4.1.1.15) (gad-67) (67 kda glutamic acid decarboxylase). [swissprot;acc:q99259]	High confidence	209.299	39.888	249.187
112	Divided	CREG1	cellular repressor of e1a-stimulated genes. [refseq;acc:nm_003851]	Low confidence	197.762	1.07206	212.013
		PBK	t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	High confidence	332.874	1.24557	267.246
	Subtracted	DLGAP4	disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0]	Low confidence	197.779	14.204	211.983
		POLE4	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]	High confidence	275.754	39.846	235.908
113	Divided	CREG2	cellular repressor of e1a-stimulated genes 2. [refseq;acc:nm_153836]	Low confidence	197.763	1.07205	212.011
		KHDRBS3	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]	High confidence	332.874	1.24557	267.246
	Subtracted	PPP2CA	serine/threonine protein phosphatase 2a, catalytic subunit, alpha isoform (ec 3.1.3.16) (pp2a-alpha) (replication protein c) (rp-c). [swissprot;acc:p05323]		194.372	39.832	234.204
		SLC11A2	natural resistance-associated macrophage protein 2 (nramp 2) (divalent metal transporter 1) (dmt1). [swissprot;acc:p49281]	Low confidence	224.763	14.197	210.566
114	Divided	DLGAP1	disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490]		197.779	1.07182	211.983
		KHDRBS1	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	High confidence	332.874	1.24557	267.246
	Subtracted	B9D1	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]		229.818	37.447	267.265
		MRPS17	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Low confidence	58	14	44
115	Divided	DLGAP4	disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0]		197.779	1.07182	211.983
		KHDRBS2	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	High confidence	332.874	1.24557	267.246
	Subtracted	HAT1	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]		277.546	37.085	240.461
		SLC25A43	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Low confidence	58	14	44
116	Divided	GNB3	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	High confidence	268.565	1.24545	334.483

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.