MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 401 to 450 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
201	RPL11	60s ribosomal protein l11. [swissprot;acc:p39026]	Subtracted	241.828	267.346	25.518
	SF4	splicing factor 4 isoform b; rna-binding protein. [refseq;acc:nm_021164]	Divided	240.133	211.382	1.13601
202	RPS4Y2	40s ribosomal protein s4, y isoform 2. [swissprot;acc:q8td47]	Subtracted	240.758	266.079	25.321
	TRPC4	short transient receptor potential channel 4 (trpc4) (trp-related protein 4) (htrp-4) (htrp4). [swissprot;acc:q9ubn4]	Divided	201.478	228.784	1.13553
203	no value	40s ribosomal protein s4, x isoform (single copy abundant mrna protein) (scr10). [swissprot;acc:p12750]	Subtracted	240.758	266.078	25.32
	TBC1D10A	ebp50-pdz interactor of 64 kda (epi64 protein). [swissprot;acc:q9bxi6]	Divided	201.515	228.752	1.13516
204	CAPN2	calpain 2, large [catalytic] subunit precursor (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (m-type) (m-calpain) (millimolar-calpain) (calpain large polypeptide l2). [swissprot;acc:p17655]	Subtracted	268.632	243.588	25.044
	TRPC5	short transient receptor potential channel 5 (trpc5) (htrp-5) (htrp5). [swissprot;acc:q9ul62]	Divided	201.515	228.752	1.13516
205	CAPN1	calpain 1, large [catalytic] subunit (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (mu-type) (mucanp) (micromolar-calpain). [swissprot;acc:p07384]	Subtracted	268.635	243.592	25.043
	LUC7L2	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	Divided	228.1	200.968	1.13501
206	LUC7L	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]		228.085	201.006	1.13472
	RPS15A	40s ribosomal protein s15a. [swissprot;acc:p39027]	Subtracted	241.411	266.414	25.003
207	EIF4G3	eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760]		237.312	212.363	24.949
	PSEN2	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	Divided	285.684	252.234	1.13261
208	no value	60s ribosomal protein l23 (l17). [swissprot;acc:p23131]	Subtracted	240.782	265.717	24.935
	SKP1A	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	Divided	285.684	252.234	1.13261
209	BCCIP	brca2 and cdkn1a-interacting protein isoform bccipalpha; brca2 and cdkn1a-interacting protein; cdk inhibitor p21 binding protein; bccipalpha; bccipbeta; tok-1alpha; tok-1beta. [refseq;acc:nm_016567]	Subtracted	240.782	265.717	24.935
	FBXW7	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	Divided	285.684	252.234	1.13261
210	no value	rna-binding protein. [refseq;acc:nm_019027]	Subtracted	237.302	212.41	24.892
	CUL2	cullin homolog 2 (cul-2). [swissprot;acc:q13617]	Divided	285.684	252.234	1.13261
211	no value	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]	Subtracted	237.302	212.41	24.892
	PSEN1	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	Divided	285.684	252.234	1.13261
212	CUL1	cullin homolog 1 (cul-1). [swissprot;acc:q13616]
	SYNCRIP	ns1-associated protein 1. [refseq;acc:nm_006372]	Subtracted	237.302	212.41	24.892
213	HNRNPR	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]
	PLDN	pallidin; pallid (mouse) homolog, pallidin. [refseq;acc:nm_012388]	Divided	210.693	186.95	1.127
214	LASS2	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]		191.644	170.192	1.12605
	MRPL4	mitochondrial ribosomal protein l4 isoform a. [refseq;acc:nm_015956]	Subtracted	241.282	266.12	24.838
215	no value	myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533]	Divided	112	126	1.125
	EIF4G1	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	Subtracted	237.292	212.457	24.835
216	MYH4	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]	Divided	112	126	1.125
	SNRPD2	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	Subtracted	226.471	201.769	24.702
217	MYH8	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]	Divided	112	126	1.125
	RPL26	60s ribosomal protein l26. [swissprot;acc:q02877]	Subtracted	242.326	267.008	24.682
218	MYH2	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]	Divided	112	126	1.125
	RPL35	60s ribosomal protein l35. [swissprot;acc:p42766]	Subtracted	242.333	266.999	24.666
219	no value	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]		242.339	266.986	24.647
	MYH3	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	Divided	112	126	1.125
220	MRPL2	mitochondrial ribosomal protein l2. [refseq;acc:nm_015950]	Subtracted	242.339	266.986	24.647
	MYH1	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	Divided	112	126	1.125
221	no value	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]
	EIF1B	protein translation factor sui1 homolog gc20. [swissprot;acc:o60739]	Subtracted	242.627	267.151	24.524
222	no value	60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]		242.153	266.673	24.52
	MYH7B	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	Divided	112	126	1.125
223	MYH13	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]
	SRR	serine racemase (ec 5.1.1.-). [swissprot;acc:q9gzt4]	Subtracted	242.153	266.673	24.52
224	RPL34	60s ribosomal protein l34. [swissprot;acc:p49207]
	SLC15A2	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]	Divided	185.969	165.623	1.12285
225	SEC61A2	protein transport protein sec61 alpha subunit isoform 2 (sec61 alpha- 2). [swissprot;acc:q9y2r3]	Subtracted	242.153	266.673	24.52
	SNRPD2	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	Divided	226.471	201.769	1.12243

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.