MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Network Comparison Type	Gene	Hugo	Interaction Map	Value Type	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 401 to 450 of 473 in total

Network Comparison Type  : Subtracted
Interaction Map  : High confidence
Value Type  : Ranked
Filtered  : 1
red  : 0
green  : 0
network_comparison  : 0

Rank	description	Hugo
3156	tektin 2 (tektin-t) (testicular tektin b1-like protein). [swissprot;acc:q9uif3]	TEKT2
3157	vesicle transport-related protein isoform a; vesicle transport-related protein. [refseq;acc:nm_016106]	SCFD1
3158	integrin alpha-6 precursor (vla-6) (cd49f). [swissprot;acc:p23229]	ITGA6
3159	trinucleotide repeat containing 6; edie; gw182 autoantigen. [refseq;acc:nm_014494]	TNRC6A
3160	cyclin k. [swissprot;acc:o75909]	CCNK
3161	brca1 associated protein. [refseq;acc:nm_006768]	BRAP
3162	phosphatidylethanolamine-binding protein (pebp) (prostatic binding protein) (hcnppp) (neuropolypeptide h3) (raf kinase inhibitor protein) (rkip) [contains: hippocampal cholinergic neurostimulating peptide (hcnp)]. [swissprot;acc:p30086]	PEBP1
3163	ccr4-not transcription complex, subunit 3; not3 (negative regulator of transcription 3, yeast) homolog. [refseq;acc:nm_014516]	CNOT3
3164	transcription factor ap-2 gamma (ap2-gamma) (activating enhancer- binding protein 2 gamma) (transcription factor erf-1). [swissprot;acc:q92754]	TFAP2C
3165	gpi transamidase component pig-s (phosphatidylinositol-glycan biosynthesis, class s protein). [swissprot;acc:q96s52]	PIGS
3166	myotubularin-related protein 2 (ec 3.1.3.-). [swissprot;acc:q13614]	MTMR2
3167	centromere/kinetochore protein zw10 homolog. [swissprot;acc:o43264]	ZW10
3168	cop-coated vesicle membrane protein p24 precursor (p24a). [swissprot;acc:q15363]	TMED2
3169	transcriptional repressor nf-x1 (ec 6.3.2.-) (nuclear transcription factor, x box-binding, 1). [swissprot;acc:q12986]	NFX1
3170	ecotropic virus integration 1 site protein. [swissprot;acc:q03112]	EVI1
3171	cyclin t2. [swissprot;acc:o60583]	CCNT2
3172	hormone sensitive lipase (ec 3.1.1.-) (hsl). [swissprot;acc:q05469]	LIPE
3173	phosphoinositide-3-kinase, class 3; vps34; phosphatidylinositol 3-kinase, class 3. [refseq;acc:nm_002647]	PIK3C3
3174	transmembrane 9 superfamily protein member 3 precursor (sm-11044 binding protein) (ep70-p-iso). [swissprot;acc:q9hd45]	TM9SF3
3175	tubulin alpha-3/alpha-7 chain (alpha-tubulin 3/7). [swissprot;acc:p05214]	TUBA3D
3176	phosphate carrier protein, mitochondrial precursor (ptp). [swissprot;acc:q00325]	SLC25A3
3177	ergic-53 protein precursor (er-golgi intermediate compartment 53 kda protein) (lectin, mannose-binding 1) (gp58) (intracellular mannose specific lectin mr60). [swissprot;acc:p49257]	LMAN1
3178	transcription initiation factor iie, beta subunit (tfiie-beta). [swissprot;acc:p29084]	no value
3179	carcinoma related gene. [refseq;acc:nm_016041]	DERL2
3180	3-hydroxyacyl-coa dehydrogenase type ii (ec 1.1.1.35) (type ii hadh) (endoplasmic reticulum-associated amyloid beta-peptide binding protein) (short-chain type dehydrogenase/reductase xh98g2). [swissprot;acc:q99714]	HSD17B10
3181	fatty aldehyde dehydrogenase (ec 1.2.1.3) (aldehyde dehydrogenase, microsomal) (aldh class 3). [swissprot;acc:p51648]	ALDH3A2
3182	transcription factor e2-alpha (immunoglobulin enhancer binding factor e12/e47) (transcription factor-3) (tcf-3) (immunoglobulin transcription factor-1) (transcription factor itf-1) (kappa-e2-binding factor). [swissprot;acc:p15923]	TCF3
3183	core-binding factor, beta subunit (cbf-beta) (polyomavirus enhancer binding protein 2 beta subunit) (pebp2-beta) (pea2-beta) (sl3-3 enhancer factor 1 beta subunit) (sl3/akv core-binding factor beta subunit). [swissprot;acc:q13951]	CBFB
3184	nuclear autoantigen sp-100 (speckled 100 kda) (nuclear dot-associated sp100 protein) (lysp100b). [swissprot;acc:p23497]	SP100
3185	ferrochelatase, mitochondrial precursor (ec 4.99.1.1) (protoheme ferro-lyase) (heme synthetase). [swissprot;acc:p22830]	FECH
3186	protein kinase c, theta type (ec 2.7.1.-) (npkc-theta). [swissprot;acc:q04759]	PRKCQ
3187	doublesex and mab-3 related transcription factor 3; testis-specific protein; dmrt-like family a3. [refseq;acc:nm_021240]	DMRT3
3188	connective tissue growth factor-like protein precursor (ctgf-l) (wnt1 inducible signaling pathway protein 2) (wisp-2) (connective tissue growth factor-related protein 58). [swissprot;acc:o76076]	WISP2
3189	ring finger protein 4. [swissprot;acc:p78317]	RNF4
3190	myotubularin-related protein 1 (ec 3.1.3.-). [swissprot;acc:q13613]	MTMR1
3191	amyloid beta precursor protein-binding protein 2; amyloid beta precursor protein (cytoplasmic tail)-binding protein 2; protein interacting with app tail 1. [refseq;acc:nm_006380]	APPBP2
3192	ubiquitin carboxyl-terminal hydrolase 13 (ec 3.1.2.15) (ubiquitin thiolesterase 13) (ubiquitin-specific processing protease 13) (deubiquitinating enzyme 13) (isopeptidase t-3) (isot-3). [swissprot;acc:q92995]	USP13
3193	rab gdp dissociation inhibitor beta (rab gdi beta) (gdi-2). [swissprot;acc:p50395]	GDI2
3194	muts protein homolog 4. [swissprot;acc:o15457]	MSH4
3195	integrin beta-3 precursor (platelet membrane glycoprotein iiia) (gpiiia) (cd61 antigen). [swissprot;acc:p05106]	ITGB3
3196	homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (methyl methanesulfonate (mmf)-inducible fragment protein 1). [swissprot;acc:q15011]	HERPUD1
3197	cisplatin resistance related protein crr9p. [refseq;acc:nm_030782]	CLPTM1L
3198	rp42 homolog; squamous cell carcinoma-related oncogene. [refseq;acc:nm_020640]	DCUN1D1
3199	complement component c6 precursor. [swissprot;acc:p13671]	C6
3200	endosome-associated fyve-domain protein. [refseq;acc:nm_014733]	ZFYVE16
3201	recessive polycystic kidney disease protein tg737 homolog. [swissprot;acc:q13099]	IFT88
3202	ran binding protein 3 isoform ranbp3-d; ran-binding protein-3. [refseq;acc:nm_007322]	RANBP3
3203	high mobility group protein 4 (hmg-4) (high mobility group protein 2a) (hmg-2a). [swissprot;acc:o15347]	HMGB3
3204	vaccinia related kinase 2; vaccinia-related kinase-2. [refseq;acc:nm_006296]	VRK2
3205	rb1-inducible coiled coil protein 1. [refseq;acc:nm_014781]	RB1CC1

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.