MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Rank	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 394 to 443 of 66312 in total

Filtered  : 1

description	Rank	Hugo	Network Comparison Type	Value Type	Interaction Map	red	green	network_comparison
26s protease regulatory subunit 4 (p26s4). [swissprot;acc:q03527]	1491	PSMC1	Subtracted	Measured	High confidence	5938.56	6376.76	438.2
	1521		Divided					1.07379
	1644			Squared		27191.5	30104.4	1.10713
	1677		Subtracted	Measured	Low confidence	8156.56	8422.67	266.11
	1870		Divided	Rooted	High confidence	62.901	64.7621	1.02959
	1881			Measured	Low confidence	8156.56	8422.67	1.03263
	1883		Subtracted	Rooted	High confidence	62.901	64.7621	1.8611
	2386				Low confidence	72.8011	75.2485	2.4474
	2496		Divided					1.03362
	2497		Subtracted	Ranked	High confidence	215.581	216.137	0.556
	2503		Divided					1.00258
	2962				Low confidence	200.017	196.692	1.0169
	2968		Subtracted					3.325
	4226			Squared		46486	45383.5	1102.5
	4304		Divided					1.02429
26s protease regulatory subunit 6a (tat-binding protein 1) (tbp-1) (proteasome subunit p50). [swissprot;acc:p17980]	1181	PSMC3	Subtracted		High confidence	27295.8	30410	3114.2
	1496		Divided					1.11409
	1511		Subtracted	Measured		5926.76	6362.33	435.57
	1527		Divided					1.07349
	1841		Subtracted		Low confidence	8111.49	8372.5	261.01
	1916		Divided	Rooted	High confidence	62.679	64.4831	1.02878
	1949		Subtracted					1.8041
	2003		Divided	Measured	Low confidence	8111.49	8372.5	1.03218
	2219		Subtracted	Rooted		72.5833	75.0673	2.484
	2293		Divided					1.03422
	2466		Subtracted	Ranked	High confidence	216.64	217.285	0.645
	2474		Divided					1.00298
	2595				Low confidence	200.484	196.948	1.01795
	2596		Subtracted					3.536
	3664			Squared		46080.5	44725.2	1355.3
	3788		Divided					1.0303
26s protease regulatory subunit 6b (mip224) (mb67 interacting protein) (tat-binding protein-7) (tbp-7). [swissprot;acc:p43686]	1060	PSMC4	Subtracted	Measured		8257.44	8556.58	299.14
	1203		Divided					1.03623
	1222		Subtracted	Squared	High confidence	26277.3	29299.3	3022
	1489		Divided					1.115
	1542		Subtracted	Rooted	Low confidence	73.251	75.8817	2.6307
	1567		Divided	Measured	High confidence	5822.25	6242.94	1.07226
	1628		Subtracted					420.69
	1667		Divided	Rooted	Low confidence	73.251	75.8817	1.03591
	1991			Ranked		199.582	195.763	1.01951
	2043		Subtracted	Rooted	High confidence	62.2342	63.9055	1.6713
	2044		Divided					1.02686
			Subtracted	Ranked	Low confidence	199.582	195.763	3.819
	2323				High confidence	217.413	218.426	1.013
	2327		Divided					1.00466
	4581		Subtracted	Squared	Low confidence	47024.3	46205.5	818.8
	4609		Divided					1.01772
26s protease regulatory subunit 7 (mss1 protein). [swissprot;acc:p35998]	877	PSMC2	Subtracted	Measured		8385.76	8703.92	318.16
	1024		Divided					1.03794
	1224		Subtracted	Squared	High confidence	26142.6	29163.8	3021.2

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.