MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	Hugo	Value Type	description	Interaction Map	Filtered	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 391 to 440 of 33156 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	Value Type	description	Interaction Map	network_comparison	red	green
49	STAMBPL1	Squared	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	High confidence	1.69212	28994.2	17134.8
	TBX19	Ranked	t-box transcription factor tbx19 (t-box protein 19). [swissprot;acc:o60806]	Low confidence	1.11289	225.438	202.569
50	ARRB1		beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	High confidence	1.26667	133	105
	CHMP2A	Squared	putative breast adenocarcinoma marker (32kd). [refseq;acc:nm_014453]		1.69212	28994.2	17134.8
	CPD	Rooted	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	Low confidence	1.13003	202.235	178.965
	HOXB4	Squared	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]		1.30449	122475	159767
	JPH3	Ranked	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]		1.11149	234.802	260.98
	KHDRBS1	Rooted	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	High confidence	1.58807	27.7254	44.0299
	MAP1LC3A	Measured	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	Low confidence	1.15571	13466.8	11652.4
	NEUROD1		neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]	High confidence	1.78438	779.167	1390.33
51	GBAS	Rooted	nipsnap2 protein (glioblastoma amplified sequence). [swissprot;acc:o75323]	Low confidence	1.12677	55.0884	62.0722
	HOXC5	Squared	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]		1.30449	122475	159767
	JPH2	Ranked	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]		1.11149	234.802	260.98
	KHDRBS2	Rooted	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	High confidence	1.58807	27.7254	44.0299
	NEUROD4	Measured	neurogenic differentiation factor 4 (neurod4). [swissprot;acc:q9hd90]		1.78438	779.167	1390.33
	SPATA6	Ranked	spermatogenesis associated 6. [refseq;acc:nm_019073]		1.26667	133	105
	STAMBP	Squared	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]		1.69212	28994.2	17134.8
	XKR7	Measured	dj310o13.4 (novel protein similar to predicted c. elegans and c. intestinalis proteins) (fragment). [sptrembl;acc:q9nug5]	Low confidence	1.15458	7563.09	8732.2
52	no value	Squared	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]		1.30449	122475	159767
	AMPD2	Ranked	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]	High confidence	1.26667	133	105
	ATG4B	Measured	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	Low confidence	1.14883	13195.9	11486.4
	CHD5		chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557]	High confidence	1.78438	779.167	1390.33
	NEURL	Rooted	neuralized-like. [refseq;acc:nm_004210]		1.58239	27.9107	44.1656
	NIPSNAP1		nipsnap1 protein. [swissprot;acc:q9bpw8]	Low confidence	1.1265	55.133	62.1073
	SMPD2	Ranked	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]		1.11149	234.802	260.98
	VPS24	Squared	neuroendocrine differentiation factor; comparative gene identification transcript 149. [refseq;acc:nm_016079]	High confidence	1.69212	28994.2	17134.8
53	BOK	Measured	bcl2-related ovarian killer. [refseq;acc:nm_032515]	Low confidence	1.14207	4955.33	5659.35
	CDK2AP1		cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1) (putative oral cancer suppressor) (deleted in oral cancer- 1) (doc-1). [swissprot;acc:o14519]	High confidence	1.78438	779.167	1390.33
	CHMP4A	Squared	protein hspc134 (protein cda04). [swissprot;acc:q9by43]		1.69212	28994.2	17134.8
	HOXD4		homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]	Low confidence	1.30449	122475	159767
	JUNB	Ranked	transcription factor jun-b. [swissprot;acc:p17275]	High confidence	1.26611	201.144	158.868
	JUND	Rooted	transcription factor jun-d. [swissprot;acc:p17535]	Low confidence	1.1257	67.1245	75.5619
	NDUFS4		nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]	High confidence	1.50369	30.8986	46.4619
	TMEM33	Ranked	db83 protein. [swissprot;acc:p57088]	Low confidence	1.11149	234.802	260.98
54	CPEB3		cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]		1.11056	267.448	240.822
	DTX2	Measured	deltex 2. [refseq;acc:nm_020892]	High confidence	1.63814	1618.84	2651.88
	HOXB5	Squared	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	Low confidence	1.30449	122475	159767
	JUNB	Rooted	transcription factor jun-b. [swissprot;acc:p17275]		1.12566	67.118	75.5523
	JUND	Ranked	transcription factor jun-d. [swissprot;acc:p17535]	High confidence	1.26425	200.941	158.941
	MAGED4	Squared	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]		1.68808	219048	129762
	SEPT8	Measured	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	Low confidence	1.13859	13203.5	15033.4
	UFC1	Rooted	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	High confidence	1.46645	40.0958	58.7986
55	no value		60s ribosomal protein l37a. [swissprot;acc:p12751]	Low confidence	1.12402	57.2649	64.3669
	CPEB4	Ranked	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]		1.11046	267.376	240.78
	DTX1	Measured	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]	High confidence	1.63399	1629.21	2662.12
	HOXA5	Squared	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]	Low confidence	1.30449	122475	159767
	KCND2	Rooted	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	High confidence	1.44038	41.6734	28.9323
	MAGEE2	Squared	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]		1.68808	219048	129762
	PRKRAP1	Ranked	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]		1.26134	320.927	254.434
	SEPT10	Measured	septin 10 isoform 1. [refseq;acc:nm_144710]	Low confidence	1.13694	13081.2	14872.6

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.