MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 375 to 424 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Hugo	Interaction Map	red	green	network_comparison
188	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]	PRMT1	High confidence	226.582	198.444	1.14179
	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	RPS6KC1	Low confidence	189.45	179.944	1.05283
189	axonemal dynein light intermediate polypeptide 1 (inner dynein arm light chain, axonemal) (hp28). [swissprot;acc:o14645]	DNALI1		214.779	204.039	1.05264
	protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22]	PRMT8	High confidence	226.582	198.444	1.14179
190	dimethylaniline monooxygenase [n-oxide forming] 5 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 5) (fmo 5) (dimethylaniline oxidase 5). [swissprot;acc:p49326]	FMO5	Low confidence	210.557	200.074	1.0524
	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]	SNRP70	High confidence	226.582	198.444	1.14179
191	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	no value
	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]	SLC15A2	Low confidence	201.43	191.43	1.05224
192	membrane-associated nucleic acid binding protein. [refseq;acc:nm_018835]	RC3H2		217.341	206.571	1.05214
	musashi 2 isoform a. [refseq;acc:nm_138962]	MSI2	High confidence	227.491	199.458	1.14055
193	hbs1-like. [refseq;acc:nm_006620]	HBS1L	Low confidence	206.166	216.913	1.05213
	musashi 1. [refseq;acc:nm_002442]	MSI1	High confidence	227.491	199.458	1.14055
194	conserved oligomeric golgi complex subunit 5 (13s golgi transport complex 90 kda subunit) (gtc-90) (golgi transport complex 1). [swissprot;acc:q9up83]	COG5	Low confidence	215.723	205.046	1.05207
	nuclear protein ukp68. [refseq;acc:nm_024824]	ZC3H14	High confidence	227.491	199.458	1.14055
195	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	no value	Low confidence	211.679	222.623	1.0517
	huntingtin interacting protein c. [refseq;acc:nm_012272]	PRPF40B	High confidence	227.971	200.417	1.13748
196	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	FOXP4		263.215	231.407	1.13745
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]	GNG12	Low confidence	211.679	222.623	1.0517
197	60s ribosomal protein l27. [swissprot;acc:p08526]	RPL27		211.912	201.556	1.05138
	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	FOXP1	High confidence	263.215	231.407	1.13745
198	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	FOXP3		263.191	231.394	1.13741
	heat-shock 20 kda like-protein p20. [swissprot;acc:o14558]	HSPB6	Low confidence	219.606	208.904	1.05123
199	alpha crystallin a chain. [swissprot;acc:p02489]	CRYAA		219.589	208.895	1.05119
	palmitoyl-protein thioesterase 2 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 2) (ppt-2) (g14). [swissprot;acc:q9umr5]	EGFL8	High confidence	242.735	276.059	1.13729
200	alpha crystallin b chain (alpha(b)-crystallin) (rosenthal fiber component). [swissprot;acc:p02511]	CRYAB	Low confidence	219.543	208.868	1.05111
	egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]	EGFL7	High confidence	242.718	276.018	1.1372
201	cytochrome c1, heme protein, mitochondrial precursor (cytochrome c-1). [swissprot;acc:p08574]	CYC1	Low confidence	208.591	219.23	1.051
	splicing factor 4 isoform b; rna-binding protein. [refseq;acc:nm_021164]	SF4	High confidence	240.133	211.382	1.13601
202	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	GNG4	Low confidence	211.51	222.252	1.05079
	short transient receptor potential channel 4 (trpc4) (trp-related protein 4) (htrp-4) (htrp4). [swissprot;acc:q9ubn4]	TRPC4	High confidence	201.478	228.784	1.13553
203	ebp50-pdz interactor of 64 kda (epi64 protein). [swissprot;acc:q9bxi6]	TBC1D10A		201.515	228.752	1.13516
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	GNG3	Low confidence	211.506	222.243	1.05076
204	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	GNG8		211.484	222.196	1.05065
	short transient receptor potential channel 5 (trpc5) (htrp-5) (htrp5). [swissprot;acc:q9ul62]	TRPC5	High confidence	201.515	228.752	1.13516
205	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	GNG5	Low confidence	211.475	222.177	1.05061
	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	LUC7L2	High confidence	228.1	200.968	1.13501
206	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	no value	Low confidence	211.457	222.138	1.05051
	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	LUC7L	High confidence	228.085	201.006	1.13472
207	anaphase-promoting complex subunit 10; anaphase-promoting complex 10. [refseq;acc:nm_014885]	ANAPC10	Low confidence	213.495	203.244	1.05044
	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	PSEN2	High confidence	285.684	252.234	1.13261
208	putative dimethylaniline monooxygenase [n-oxide forming] 6 (ec 1.14.13.8) (flavin-containing monooxygenase 6) (fmo 6) (dimethylaniline oxidase 6). [swissprot;acc:o60774]	FMO6P	Low confidence	209.792	199.758	1.05023
	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	SKP1A	High confidence	285.684	252.234	1.13261
209	dimethylaniline monooxygenase [n-oxide forming] 3 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 3) (fmo 3) (dimethylaniline oxidase 3) (fmo form 2) (fmo ii). [swissprot;acc:p31513]	FMO3	Low confidence	209.778	199.757	1.05017
	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	FBXW7	High confidence	285.684	252.234	1.13261
210	cullin homolog 2 (cul-2). [swissprot;acc:q13617]	CUL2
	dimethylaniline monooxygenase [n-oxide forming] 2 (ec 1.14.13.8) (pulmonary flavin-containing monooxygenase 2) (fmo 2) (dimethylaniline oxidase 2) (fmo 1b1). [swissprot;acc:q99518]	FMO2	Low confidence	209.782	199.761	1.05016
211	dimethylaniline monooxygenase [n-oxide forming] 1 (ec 1.14.13.8) (fetal hepatic flavin-containing monooxygenase 1) (fmo 1) (dimethylaniline oxidase 1). [swissprot;acc:q01740]	FMO1		209.768	199.756	1.05012
	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	PSEN1	High confidence	285.684	252.234	1.13261
212	cullin homolog 1 (cul-1). [swissprot;acc:q13616]	CUL1
	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	GNG11	Low confidence	211.383	221.976	1.05011

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.