MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Network Comparison Type	Hugo	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 375 to 424 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	description	Network Comparison Type	Hugo	Interaction Map	red	green	network_comparison
94	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Divided	no value	High confidence	88.2482	110.265	1.24949
	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]		RASAL2	Low confidence	247.087	228.693	1.08043
95	amino acid transporter xat2; likely ortholog of mouse aspartate/glutamate transporter 1 (agt1). [refseq;acc:nm_138817]		SLC7A13		200.497	185.679	1.0798
		Subtracted					14.818
	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Divided	MAGEA9	High confidence	88.2482	110.265	1.24949
	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	Subtracted	RAP1GAP		249.663	298.263	48.6
96	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]		ATF3		201.949	153.671	48.278
	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Divided	MAGEA8		88.2482	110.265	1.24949
	y+l amino acid transporter 1 (y(+)l-type amino acid transporter 1) (y+lat-1) (y+lat1) (monocyte amino acid permease 2) (mop-2). [swissprot;acc:q9um01]		SLC7A7	Low confidence	200.497	185.679	1.0798
		Subtracted					14.818
97	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]		APBA1	High confidence	271.752	225.68	46.072
	cystine/glutamate transporter (amino acid transport system xc-) (xct) (calcium channel blocker resistance protein ccbr1). [swissprot;acc:q9upy5]	Divided	SLC7A11	Low confidence	200.497	185.679	1.0798
		Subtracted					14.818
	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Divided	MAGEC1	High confidence	88.2482	110.265	1.24949
98	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]		MAGEA4
	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	Subtracted	FOS		204.641	160.957	43.684
	solute carrier family 7 (cationic amino acid transporter, y+ system), member 6. [refseq;acc:nm_003983]	Divided	SLC7A6	Low confidence	200.497	185.679	1.0798
		Subtracted					14.818
99	eukaryotic translation initiation factor 4b (eif-4b). [swissprot;acc:p23588]	Divided	EIF4B				1.0798
		Subtracted					14.818
	jun dimerization protein. [refseq;acc:nm_130469]		no value	High confidence	204.641	160.957	43.684
	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	Divided			88.2482	110.265	1.24949
100	b(0,+)-type amino acid transporter 1 (b(0,+)at) (glycoprotein- associated amino acid transporter b0,+at1). [swissprot;acc:p82251]		SLC7A9	Low confidence	200.497	185.679	1.0798
		Subtracted					14.818
	fos-related antigen 2. [swissprot;acc:p15408]		FOSL2	High confidence	204.641	161.046	43.595
	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	Divided	MAGEA10		88.2482	110.265	1.24949
101	coagulation factor xiii a chain precursor (ec 2.3.2.13) (protein- glutamine gamma-glutamyltransferase a chain) (transglutaminase a chain). [swissprot;acc:p00488]	Subtracted	F13A1	Low confidence	226.395	211.713	14.682
	leucine zipper domain protein. [refseq;acc:nm_024589]	Divided	ROGDI		221.996	238.82	1.07579
	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]		MAGEB4	High confidence	88.2482	110.265	1.24949
	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	Subtracted	FOSB		204.641	161.051	43.59
102	diacylglycerol kinase, theta (ec 2.7.1.107) (diglyceride kinase) (dgk- theta) (dag kinase theta). [swissprot;acc:p52824]	Divided	DGKQ	Low confidence	229.556	213.456	1.07543
	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	Subtracted	FOSL1	High confidence	204.642	161.068	43.574
	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	Divided	MAGED2		88.2482	110.265	1.24949
	protein-glutamine gamma-glutamyltransferase k (ec 2.3.2.13) (transglutaminase k) (tgase k) (tgk) (tg(k)) (transglutaminase 1) (epidermal tgase). [swissprot;acc:p22735]	Subtracted	TGM1	Low confidence	226.395	211.713	14.682
103	goodpasture antigen-binding protein (ec 2.7.1.37) (gpbp) (collagen type iv alpha 3 binding protein) (star-related lipid transfer protein 11) (stard11) (start domain-containing protein 11). [swissprot;acc:q9y5p4]		COL4A3BP		220.969	235.572	14.603
	transcription factor jun-b. [swissprot;acc:p17275]		JUNB	High confidence	201.144	158.868	42.276
	trophinin. [swissprot;acc:q12816]	Divided	TRO		88.2482	110.265	1.24949
	vacuolar protein sorting 16 (hvps16). [swissprot;acc:q9h269]		PTPRA	Low confidence	203.948	189.652	1.07538
104	adiponectin receptor 2. [refseq;acc:nm_024551]		ADIPOR2		219.277	204.212	1.07377
	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]		HOMER2	High confidence	252.371	202.016	1.24926
	natural resistance-associated macrophage protein 1 (nramp 1). [swissprot;acc:p49279]	Subtracted	SLC11A1	Low confidence	225.666	211.107	14.559
	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]		TARDBP	High confidence	256.228	298.438	42.21
105	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]		B9D1	Low confidence	213.243	227.616	14.373
	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	Divided	GNB1	High confidence	266.716	333.165	1.24914
	transcription factor e2f1 (e2f-1) (retinoblastoma binding protein 3) (rbbp-3) (prb-binding protein e2f-1) (pbr3) (retinoblastoma-associated protein 1) (rbap-1). [swissprot;acc:q01094]		E2F1	Low confidence	220.497	205.364	1.07369
	transcription factor jun-d. [swissprot;acc:p17535]	Subtracted	JUND	High confidence	200.941	158.941	42
106	disks large-associated protein 3 (dap-3) (sap90/psd-95-associated protein 3) (sapap3) (psd-95/sap90 binding protein 3) (fragment). [swissprot;acc:o95886]		DLGAP3	Low confidence	197.731	212.069	14.338
	nostrin. [refseq;acc:nm_052946]		NOSTRIN	High confidence	209.299	249.187	39.888
	transcription factor e2f2 (e2f-2). [swissprot;acc:q14209]	Divided	E2F2	Low confidence	220.497	205.364	1.07369
	ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807]		COQ7	High confidence	252.329	202.004	1.24913

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.