MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Network Comparison Type	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 375 to 424 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	network_comparison	green
94	GNAO1	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	Subtracted	High confidence	249.663	48.6	298.263
	RASAL2	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	Divided	Low confidence	247.087	1.08043	228.693
95	MAGEA9	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]		High confidence	88.2482	1.24949	110.265
	RAP1GAP	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	Subtracted		249.663	48.6	298.263
	SLC7A13	amino acid transporter xat2; likely ortholog of mouse aspartate/glutamate transporter 1 (agt1). [refseq;acc:nm_138817]	Divided	Low confidence	200.497	1.0798	185.679
			Subtracted			14.818
96	ATF3	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]		High confidence	201.949	48.278	153.671
	MAGEA8	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Divided		88.2482	1.24949	110.265
	SLC7A7	y+l amino acid transporter 1 (y(+)l-type amino acid transporter 1) (y+lat-1) (y+lat1) (monocyte amino acid permease 2) (mop-2). [swissprot;acc:q9um01]		Low confidence	200.497	1.0798	185.679
			Subtracted			14.818
97	APBA1	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]		High confidence	271.752	46.072	225.68
	MAGEC1	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Divided		88.2482	1.24949	110.265
	SLC7A11	cystine/glutamate transporter (amino acid transport system xc-) (xct) (calcium channel blocker resistance protein ccbr1). [swissprot;acc:q9upy5]		Low confidence	200.497	1.0798	185.679
			Subtracted			14.818
98	FOS	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]		High confidence	204.641	43.684	160.957
	MAGEA4	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	Divided		88.2482	1.24949	110.265
	SLC7A6	solute carrier family 7 (cationic amino acid transporter, y+ system), member 6. [refseq;acc:nm_003983]		Low confidence	200.497	1.0798	185.679
			Subtracted			14.818
99	no value	jun dimerization protein. [refseq;acc:nm_130469]		High confidence	204.641	43.684	160.957
		melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	Divided		88.2482	1.24949	110.265
	EIF4B	eukaryotic translation initiation factor 4b (eif-4b). [swissprot;acc:p23588]		Low confidence	200.497	1.0798	185.679
			Subtracted			14.818
100	FOSL2	fos-related antigen 2. [swissprot;acc:p15408]		High confidence	204.641	43.595	161.046
	MAGEA10	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	Divided		88.2482	1.24949	110.265
	SLC7A9	b(0,+)-type amino acid transporter 1 (b(0,+)at) (glycoprotein- associated amino acid transporter b0,+at1). [swissprot;acc:p82251]		Low confidence	200.497	1.0798	185.679
			Subtracted			14.818
101	F13A1	coagulation factor xiii a chain precursor (ec 2.3.2.13) (protein- glutamine gamma-glutamyltransferase a chain) (transglutaminase a chain). [swissprot;acc:p00488]			226.395	14.682	211.713
	FOSB	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]		High confidence	204.641	43.59	161.051
	MAGEB4	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	Divided		88.2482	1.24949	110.265
	ROGDI	leucine zipper domain protein. [refseq;acc:nm_024589]		Low confidence	221.996	1.07579	238.82
102	DGKQ	diacylglycerol kinase, theta (ec 2.7.1.107) (diglyceride kinase) (dgk- theta) (dag kinase theta). [swissprot;acc:p52824]			229.556	1.07543	213.456
	FOSL1	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	Subtracted	High confidence	204.642	43.574	161.068
	MAGED2	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	Divided		88.2482	1.24949	110.265
	TGM1	protein-glutamine gamma-glutamyltransferase k (ec 2.3.2.13) (transglutaminase k) (tgase k) (tgk) (tg(k)) (transglutaminase 1) (epidermal tgase). [swissprot;acc:p22735]	Subtracted	Low confidence	226.395	14.682	211.713
103	COL4A3BP	goodpasture antigen-binding protein (ec 2.7.1.37) (gpbp) (collagen type iv alpha 3 binding protein) (star-related lipid transfer protein 11) (stard11) (start domain-containing protein 11). [swissprot;acc:q9y5p4]			220.969	14.603	235.572
	JUNB	transcription factor jun-b. [swissprot;acc:p17275]		High confidence	201.144	42.276	158.868
	PTPRA	vacuolar protein sorting 16 (hvps16). [swissprot;acc:q9h269]	Divided	Low confidence	203.948	1.07538	189.652
	TRO	trophinin. [swissprot;acc:q12816]		High confidence	88.2482	1.24949	110.265
104	ADIPOR2	adiponectin receptor 2. [refseq;acc:nm_024551]		Low confidence	219.277	1.07377	204.212
	HOMER2	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]		High confidence	252.371	1.24926	202.016
	SLC11A1	natural resistance-associated macrophage protein 1 (nramp 1). [swissprot;acc:p49279]	Subtracted	Low confidence	225.666	14.559	211.107
	TARDBP	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]		High confidence	256.228	42.21	298.438
105	B9D1	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]		Low confidence	213.243	14.373	227.616
	E2F1	transcription factor e2f1 (e2f-1) (retinoblastoma binding protein 3) (rbbp-3) (prb-binding protein e2f-1) (pbr3) (retinoblastoma-associated protein 1) (rbap-1). [swissprot;acc:q01094]	Divided		220.497	1.07369	205.364
	GNB1	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]		High confidence	266.716	1.24914	333.165
	JUND	transcription factor jun-d. [swissprot;acc:p17535]	Subtracted		200.941	42	158.941
106	COQ7	ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807]	Divided		252.329	1.24913	202.004
	DLGAP3	disks large-associated protein 3 (dap-3) (sap90/psd-95-associated protein 3) (sapap3) (psd-95/sap90 binding protein 3) (fragment). [swissprot;acc:o95886]	Subtracted	Low confidence	197.731	14.338	212.069
	E2F2	transcription factor e2f2 (e2f-2). [swissprot;acc:q14209]	Divided		220.497	1.07369	205.364
	NOSTRIN	nostrin. [refseq;acc:nm_052946]	Subtracted	High confidence	209.299	39.888	249.187

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.