MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 375 to 424 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
188	PRMT1	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]	High confidence	226.582	198.444	1.14179
	RPS6KC1	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	Low confidence	189.45	179.944	1.05283
189	DNALI1	axonemal dynein light intermediate polypeptide 1 (inner dynein arm light chain, axonemal) (hp28). [swissprot;acc:o14645]		214.779	204.039	1.05264
	PRMT8	protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22]	High confidence	226.582	198.444	1.14179
190	FMO5	dimethylaniline monooxygenase [n-oxide forming] 5 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 5) (fmo 5) (dimethylaniline oxidase 5). [swissprot;acc:p49326]	Low confidence	210.557	200.074	1.0524
	SNRP70	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]	High confidence	226.582	198.444	1.14179
191	no value	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]
	SLC15A2	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]	Low confidence	201.43	191.43	1.05224
192	MSI2	musashi 2 isoform a. [refseq;acc:nm_138962]	High confidence	227.491	199.458	1.14055
	RC3H2	membrane-associated nucleic acid binding protein. [refseq;acc:nm_018835]	Low confidence	217.341	206.571	1.05214
193	HBS1L	hbs1-like. [refseq;acc:nm_006620]		206.166	216.913	1.05213
	MSI1	musashi 1. [refseq;acc:nm_002442]	High confidence	227.491	199.458	1.14055
194	COG5	conserved oligomeric golgi complex subunit 5 (13s golgi transport complex 90 kda subunit) (gtc-90) (golgi transport complex 1). [swissprot;acc:q9up83]	Low confidence	215.723	205.046	1.05207
	ZC3H14	nuclear protein ukp68. [refseq;acc:nm_024824]	High confidence	227.491	199.458	1.14055
195	no value	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	Low confidence	211.679	222.623	1.0517
	PRPF40B	huntingtin interacting protein c. [refseq;acc:nm_012272]	High confidence	227.971	200.417	1.13748
196	FOXP4	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]		263.215	231.407	1.13745
	GNG12	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]	Low confidence	211.679	222.623	1.0517
197	FOXP1	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	High confidence	263.215	231.407	1.13745
	RPL27	60s ribosomal protein l27. [swissprot;acc:p08526]	Low confidence	211.912	201.556	1.05138
198	FOXP3	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	High confidence	263.191	231.394	1.13741
	HSPB6	heat-shock 20 kda like-protein p20. [swissprot;acc:o14558]	Low confidence	219.606	208.904	1.05123
199	CRYAA	alpha crystallin a chain. [swissprot;acc:p02489]		219.589	208.895	1.05119
	EGFL8	palmitoyl-protein thioesterase 2 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 2) (ppt-2) (g14). [swissprot;acc:q9umr5]	High confidence	242.735	276.059	1.13729
200	CRYAB	alpha crystallin b chain (alpha(b)-crystallin) (rosenthal fiber component). [swissprot;acc:p02511]	Low confidence	219.543	208.868	1.05111
	EGFL7	egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]	High confidence	242.718	276.018	1.1372
201	CYC1	cytochrome c1, heme protein, mitochondrial precursor (cytochrome c-1). [swissprot;acc:p08574]	Low confidence	208.591	219.23	1.051
	SF4	splicing factor 4 isoform b; rna-binding protein. [refseq;acc:nm_021164]	High confidence	240.133	211.382	1.13601
202	GNG4	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	Low confidence	211.51	222.252	1.05079
	TRPC4	short transient receptor potential channel 4 (trpc4) (trp-related protein 4) (htrp-4) (htrp4). [swissprot;acc:q9ubn4]	High confidence	201.478	228.784	1.13553
203	GNG3	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	Low confidence	211.506	222.243	1.05076
	TBC1D10A	ebp50-pdz interactor of 64 kda (epi64 protein). [swissprot;acc:q9bxi6]	High confidence	201.515	228.752	1.13516
204	GNG8	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	Low confidence	211.484	222.196	1.05065
	TRPC5	short transient receptor potential channel 5 (trpc5) (htrp-5) (htrp5). [swissprot;acc:q9ul62]	High confidence	201.515	228.752	1.13516
205	GNG5	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	Low confidence	211.475	222.177	1.05061
	LUC7L2	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	High confidence	228.1	200.968	1.13501
206	no value	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	Low confidence	211.457	222.138	1.05051
	LUC7L	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	High confidence	228.085	201.006	1.13472
207	ANAPC10	anaphase-promoting complex subunit 10; anaphase-promoting complex 10. [refseq;acc:nm_014885]	Low confidence	213.495	203.244	1.05044
	PSEN2	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	High confidence	285.684	252.234	1.13261
208	FMO6P	putative dimethylaniline monooxygenase [n-oxide forming] 6 (ec 1.14.13.8) (flavin-containing monooxygenase 6) (fmo 6) (dimethylaniline oxidase 6). [swissprot;acc:o60774]	Low confidence	209.792	199.758	1.05023
	SKP1A	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	High confidence	285.684	252.234	1.13261
209	FBXW7	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]
	FMO3	dimethylaniline monooxygenase [n-oxide forming] 3 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 3) (fmo 3) (dimethylaniline oxidase 3) (fmo form 2) (fmo ii). [swissprot;acc:p31513]	Low confidence	209.778	199.757	1.05017
210	CUL2	cullin homolog 2 (cul-2). [swissprot;acc:q13617]	High confidence	285.684	252.234	1.13261
	FMO2	dimethylaniline monooxygenase [n-oxide forming] 2 (ec 1.14.13.8) (pulmonary flavin-containing monooxygenase 2) (fmo 2) (dimethylaniline oxidase 2) (fmo 1b1). [swissprot;acc:q99518]	Low confidence	209.782	199.761	1.05016
211	FMO1	dimethylaniline monooxygenase [n-oxide forming] 1 (ec 1.14.13.8) (fetal hepatic flavin-containing monooxygenase 1) (fmo 1) (dimethylaniline oxidase 1). [swissprot;acc:q01740]		209.768	199.756	1.05012
	PSEN1	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	High confidence	285.684	252.234	1.13261
212	CUL1	cullin homolog 1 (cul-1). [swissprot;acc:q13616]
	GNG11	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	Low confidence	211.383	221.976	1.05011

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.