MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 358 to 407 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
179	RPL6	60s ribosomal protein l6 (tax-responsive enhancer element binding protein 107) (taxreb107) (neoplasm-related protein c140). [swissprot;acc:q02878]	Low confidence	209.954	221.607	1.0555
180	DCHS1	protocadherin 16 precursor (cadherin 19) (cadherin fibroblast 1). [swissprot;acc:q96jq0]		218.925	207.441	1.05536
	TARDBP	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	High confidence	256.228	298.438	1.16474
181	B9D1	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]		229.818	267.265	1.16294
	STAMBPL1	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	Low confidence	196.362	206.979	1.05407
182	HAT1	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	High confidence	277.546	240.461	1.15422
	PXK	px serine/threonine kinase. [refseq;acc:nm_017771]	Low confidence	196.372	206.947	1.05385
183	no value	bromodomain adjacent to zinc finger domain protein 1a (atp-utilizing chromatin assembly and remodeling factor 1) (hacf1) (atp-dependent chromatin remodelling protein) (williams syndrome transcription factor-related chromatin remodeling factor 180) (wcrf180) (hwalp1) (chrac subunit acf1) (hspc317). [swissprot;acc:q9nrl2]
	NCBP2	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	High confidence	228.306	198.011	1.153
184	OSR1	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]		274.027	237.79	1.15239
	TSGA10	testis specific, 10. [refseq;acc:nm_025244]	Low confidence	196.373	206.946	1.05384
185	no value	f-actin capping protein alpha-2 subunit (capz alpha-2). [swissprot;acc:p47755]		212.589	201.755	1.0537
	ADIPOR2	adiponectin receptor 2. [refseq;acc:nm_024551]	High confidence	281.582	246.371	1.14292
186	FLNB	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]		226.582	198.444	1.14179
	STAMBP	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	Low confidence	196.381	206.921	1.05367
187	no value	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]		189.373	179.829	1.05307
	REV1	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]	High confidence	226.582	198.444	1.14179
188	PRMT1	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]
	RPS6KC1	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	Low confidence	189.45	179.944	1.05283
189	DNALI1	axonemal dynein light intermediate polypeptide 1 (inner dynein arm light chain, axonemal) (hp28). [swissprot;acc:o14645]		214.779	204.039	1.05264
	PRMT8	protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22]	High confidence	226.582	198.444	1.14179
190	FMO5	dimethylaniline monooxygenase [n-oxide forming] 5 (ec 1.14.13.8) (hepatic flavin-containing monooxygenase 5) (fmo 5) (dimethylaniline oxidase 5). [swissprot;acc:p49326]	Low confidence	210.557	200.074	1.0524
	SNRP70	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]	High confidence	226.582	198.444	1.14179
191	no value	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]
	SLC15A2	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]	Low confidence	201.43	191.43	1.05224
192	MSI2	musashi 2 isoform a. [refseq;acc:nm_138962]	High confidence	227.491	199.458	1.14055
	RC3H2	membrane-associated nucleic acid binding protein. [refseq;acc:nm_018835]	Low confidence	217.341	206.571	1.05214
193	HBS1L	hbs1-like. [refseq;acc:nm_006620]		206.166	216.913	1.05213
	MSI1	musashi 1. [refseq;acc:nm_002442]	High confidence	227.491	199.458	1.14055
194	COG5	conserved oligomeric golgi complex subunit 5 (13s golgi transport complex 90 kda subunit) (gtc-90) (golgi transport complex 1). [swissprot;acc:q9up83]	Low confidence	215.723	205.046	1.05207
	ZC3H14	nuclear protein ukp68. [refseq;acc:nm_024824]	High confidence	227.491	199.458	1.14055
195	no value	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]	Low confidence	211.679	222.623	1.0517
	PRPF40B	huntingtin interacting protein c. [refseq;acc:nm_012272]	High confidence	227.971	200.417	1.13748
196	FOXP4	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]		263.215	231.407	1.13745
	GNG12	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]	Low confidence	211.679	222.623	1.0517
197	FOXP1	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	High confidence	263.215	231.407	1.13745
	RPL27	60s ribosomal protein l27. [swissprot;acc:p08526]	Low confidence	211.912	201.556	1.05138
198	FOXP3	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	High confidence	263.191	231.394	1.13741
	HSPB6	heat-shock 20 kda like-protein p20. [swissprot;acc:o14558]	Low confidence	219.606	208.904	1.05123
199	CRYAA	alpha crystallin a chain. [swissprot;acc:p02489]		219.589	208.895	1.05119
	EGFL8	palmitoyl-protein thioesterase 2 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 2) (ppt-2) (g14). [swissprot;acc:q9umr5]	High confidence	242.735	276.059	1.13729
200	CRYAB	alpha crystallin b chain (alpha(b)-crystallin) (rosenthal fiber component). [swissprot;acc:p02511]	Low confidence	219.543	208.868	1.05111
	EGFL7	egf-like-domain, multiple 7; neu1 protein. [refseq;acc:nm_016215]	High confidence	242.718	276.018	1.1372
201	CYC1	cytochrome c1, heme protein, mitochondrial precursor (cytochrome c-1). [swissprot;acc:p08574]	Low confidence	208.591	219.23	1.051
	SF4	splicing factor 4 isoform b; rna-binding protein. [refseq;acc:nm_021164]	High confidence	240.133	211.382	1.13601
202	GNG4	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	Low confidence	211.51	222.252	1.05079
	TRPC4	short transient receptor potential channel 4 (trpc4) (trp-related protein 4) (htrp-4) (htrp4). [swissprot;acc:q9ubn4]	High confidence	201.478	228.784	1.13553
203	GNG3	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	Low confidence	211.506	222.243	1.05076
	TBC1D10A	ebp50-pdz interactor of 64 kda (epi64 protein). [swissprot;acc:q9bxi6]	High confidence	201.515	228.752	1.13516
204	GNG8	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	Low confidence	211.484	222.196	1.05065

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.