MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	Hugo	Value Type	description	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 330 to 379 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Network Comparison Type	Hugo	description	Interaction Map	red	green	network_comparison
83	Divided	MAGED4	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	High confidence	88.2482	110.265	1.24949
	Subtracted	HOMER1	homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]		252.309	201.998	50.311
		STARD7	star-related lipid transfer protein 7 (stard7) (start domain- containing protein 7) (gtt1 protein). [swissprot;acc:q9nqz5]	Low confidence	228.743	210.764	17.979
84	Divided	no value	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]		226.338	207.874	1.08882
		MAGEE2	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	High confidence	88.2482	110.265	1.24949
	Subtracted	HOMER3	homer, neuronal immediate early gene, 3. [refseq;acc:nm_004838]		252.296	201.995	50.301
		OPHN1	oligophrenin 1. [swissprot;acc:o60890]	Low confidence	233.837	215.973	17.864
85	Divided	no value	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	High confidence	88.2482	110.265	1.24949
		KCND2	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	Low confidence	225.735	245.308	1.08671
	Subtracted	ARHGAP26	oligophrenin-1 like protein (gtpase regulator associated with focal adhesion kinase). [swissprot;acc:q9una1]		233.592	215.846	17.746
		UNC84A	sad1/unc-84 protein-like 1. [swissprot;acc:o94901]	High confidence	296.677	247.559	49.118
86	Divided	DFFB	dna fragmentation factor 40 kda subunit (ec 3.-.-.-) (dff-40) (caspase-activated deoxyribonuclease) (caspase-activated dnase) (cad) (caspase-activated nuclease) (cpan). [swissprot;acc:o76075]	Low confidence	233.922	215.309	1.08645
		MAGEA11	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	High confidence	88.2482	110.265	1.24949
	Subtracted	DGCR14	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]		335	286	49
		ROGDI	leucine zipper domain protein. [refseq;acc:nm_024589]	Low confidence	221.996	238.82	16.824
87	Divided	KCND3	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]		225.545	244.933	1.08596
		MAGEA2B	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	High confidence	88.2482	110.265	1.24949
	Subtracted	DGKQ	diacylglycerol kinase, theta (ec 2.7.1.107) (diglyceride kinase) (dgk- theta) (dag kinase theta). [swissprot;acc:p52824]	Low confidence	229.556	213.456	16.1
		RBM15B	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	High confidence	249.663	298.263	48.6
88	Divided	no value	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]		88.2482	110.265	1.24949
		KCND1	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]	Low confidence	225.428	244.701	1.0855
	Subtracted	CPD	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]		16	32	16
		RGS19	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	High confidence	249.663	298.263	48.6
89	Divided	MAGEA6	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]		88.2482	110.265	1.24949
		STARD7	star-related lipid transfer protein 7 (stard7) (start domain- containing protein 7) (gtt1 protein). [swissprot;acc:q9nqz5]	Low confidence	228.743	210.764	1.0853
	Subtracted	RBM15	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	High confidence	249.663	298.263	48.6
		UBR4	retinoblastoma-associated factor 600. [refseq;acc:nm_020765]	Low confidence	165.535	149.799	15.736
90	Divided	NDN	necdin. [swissprot;acc:q99608]	High confidence	88.2482	110.265	1.24949
		TAF2	tbp-associated factor 2; taf2 rna polymerase ii, tata box binding protein (tbp)-associated factor, 150 kd; tata box binding protein (tbp)-associated factor, rna polymerase ii, b, 150kd; cofactor of initiator function, 150kd subunit. [refseq;acc:nm_003184]	Low confidence	237.567	219.229	1.08365
	Subtracted	NEURL	neuralized-like. [refseq;acc:nm_004210]		232.704	216.996	15.708
		RGS20	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	High confidence	249.663	298.263	48.6
91	Divided	MAGED1	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]		88.2482	110.265	1.24949
		OPHN1	oligophrenin 1. [swissprot;acc:o60890]	Low confidence	233.837	215.973	1.08271
	Subtracted	FAM89B	mouse mammary turmor virus receptor homolog 1. [refseq;acc:nm_152832]		227.429	211.97	15.459
		LBX1	transcription factor lbx1. [swissprot;acc:p52954]	High confidence	249.663	298.263	48.6
92	Divided	ARHGAP26	oligophrenin-1 like protein (gtpase regulator associated with focal adhesion kinase). [swissprot;acc:q9una1]	Low confidence	233.592	215.846	1.08222
		MAGEF1	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	High confidence	88.2482	110.265	1.24949
	Subtracted	E2F1	transcription factor e2f1 (e2f-1) (retinoblastoma binding protein 3) (rbbp-3) (prb-binding protein e2f-1) (pbr3) (retinoblastoma-associated protein 1) (rbap-1). [swissprot;acc:q01094]	Low confidence	220.497	205.364	15.133
		GPSM2	mosaic protein lgn. [swissprot;acc:p81274]	High confidence	249.663	298.263	48.6
93	Divided	DAB2IP	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	Low confidence	247.334	228.84	1.08082
		MAGEB6B	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	High confidence	88.2482	110.265	1.24949
	Subtracted	E2F2	transcription factor e2f2 (e2f-2). [swissprot;acc:q14209]	Low confidence	220.497	205.364	15.133
		RGS17	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	High confidence	249.663	298.263	48.6
94	Divided	no value	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]		88.2482	110.265	1.24949
		RASAL2	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	Low confidence	247.087	228.693	1.08043
	Subtracted	ADIPOR2	adiponectin receptor 2. [refseq;acc:nm_024551]		219.277	204.212	15.065
		GNAO1	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	High confidence	249.663	298.263	48.6
95	Divided	MAGEA9	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]		88.2482	110.265	1.24949
		SLC7A13	amino acid transporter xat2; likely ortholog of mouse aspartate/glutamate transporter 1 (agt1). [refseq;acc:nm_138817]	Low confidence	200.497	185.679	1.0798
	Subtracted	RAP1GAP	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	High confidence	249.663	298.263	48.6

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.