MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 325 to 374 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Interaction Map	red	green	network_comparison
163	eap30 subunit of ell complex. [refseq;acc:nm_007241]	SNF8	High confidence	209.299	249.187	1.19058
	vacuolar assembly protein vps41 homolog (s53). [swissprot;acc:p49754]	VPS41	Low confidence	202.698	191.393	1.05907
164	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	SLC39A6	High confidence	209.299	249.187	1.19058
	protein phosphatase 2c beta isoform (ec 3.1.3.16) (pp2c-beta). [swissprot;acc:o75688]	PPM1B	Low confidence	196.714	185.758	1.05898
165	calpain 1, large [catalytic] subunit (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (mu-type) (mucanp) (micromolar-calpain). [swissprot;acc:p07384]	CAPN1		222.508	210.345	1.05782
	glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]	GAD2	High confidence	209.299	249.187	1.19058
166	calpain 2, large [catalytic] subunit precursor (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (m-type) (m-calpain) (millimolar-calpain) (calpain large polypeptide l2). [swissprot;acc:p17655]	CAPN2	Low confidence	222.502	210.342	1.05781
	gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [swissprot;acc:q99747]	NAPG	High confidence	209.299	249.187	1.19058
167	glutamate decarboxylase, 67 kda isoform (ec 4.1.1.15) (gad-67) (67 kda glutamic acid decarboxylase). [swissprot;acc:q99259]	GAD1
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	RHOBTB2	Low confidence	212.695	201.131	1.05749
168	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	no value	High confidence	82.5916	98.0548	1.18722
	proto-oncogene tyrosine-protein kinase fer (ec 2.7.1.112) (p94-fer) (c-fer). [swissprot;acc:p16591]	FER	Low confidence	216.796	205.073	1.05717
169	60s ribosomal protein l29 (cell surface heparin binding protein hip). [swissprot;acc:p47914]	RPL29		216.79	205.07	1.05715
	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	ATG3	High confidence	82.5916	98.0548	1.18722
170	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483]	TIA1		227.199	192.715	1.17894
	proto-oncogene tyrosine-protein kinase fes/fps (ec 2.7.1.112) (c-fes). [swissprot;acc:p07332]	FES	Low confidence	216.783	205.066	1.05714
171	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	FOXP3		219.889	208.064	1.05683
	nucleolysin tiar (tia-1 related protein). [swissprot;acc:q01085]	TIAL1	High confidence	227.202	192.823	1.17829
172	cg9578-like; yeast ypr037w and worm c02c2.6 predicted proteins-like. [refseq;acc:nm_152902]	TIPRL		174.667	205.556	1.17685
	f-actin capping protein alpha-1 subunit (capz alpha-1). [swissprot;acc:p52907]	CAPZA1	Low confidence	213.671	202.205	1.0567
173	sad1/unc-84 protein-like 1. [swissprot;acc:o94901]	UNC84A		221.678	209.795	1.05664
	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641]	SNRPD1	High confidence	227.032	193.056	1.17599
174	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	DGCR14		335	286	1.17133
	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	FOXP1	Low confidence	219.6	207.907	1.05624
175	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]	COPS3	High confidence	199.949	234.187	1.17123
	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	FOXP4	Low confidence	219.593	207.903	1.05623
176	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]	POLE4	High confidence	275.754	235.908	1.1689
	tumor endothelial marker 6; thyroid specific ptb domain protein; tensin 3. [refseq;acc:nm_022748]	TNS3	Low confidence	219.336	207.703	1.05601
177	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	NCBP2L	High confidence	229.406	196.695	1.1663
	ribonuclease p protein subunit p20 (ec 3.1.26.5) (rnasep protein p20) (hpop7). [swissprot;acc:o75817]	POP7	Low confidence	209.954	221.607	1.0555
178	3'(2'), 5'-bisphosphate nucleotidase 1; bisphosphate 3'-nucleotidase; bpntase; pap-inositol-1,4-phosphatase. [refseq;acc:nm_006085]	BPNT1
	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	no value	High confidence	226.887	194.72	1.1652
179	60s ribosomal protein l6 (tax-responsive enhancer element binding protein 107) (taxreb107) (neoplasm-related protein c140). [swissprot;acc:q02878]	RPL6	Low confidence	209.954	221.607	1.0555
	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	no value	High confidence	226.884	194.79	1.16476
180	protocadherin 16 precursor (cadherin 19) (cadherin fibroblast 1). [swissprot;acc:q96jq0]	DCHS1	Low confidence	218.925	207.441	1.05536
	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	TARDBP	High confidence	256.228	298.438	1.16474
181	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	STAMBPL1	Low confidence	196.362	206.979	1.05407
	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]	B9D1	High confidence	229.818	267.265	1.16294
182	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	HAT1		277.546	240.461	1.15422
	px serine/threonine kinase. [refseq;acc:nm_017771]	PXK	Low confidence	196.372	206.947	1.05385
183	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	NCBP2	High confidence	228.306	198.011	1.153
	bromodomain adjacent to zinc finger domain protein 1a (atp-utilizing chromatin assembly and remodeling factor 1) (hacf1) (atp-dependent chromatin remodelling protein) (williams syndrome transcription factor-related chromatin remodeling factor 180) (wcrf180) (hwalp1) (chrac subunit acf1) (hspc317). [swissprot;acc:q9nrl2]	no value	Low confidence	196.372	206.947	1.05385
184	odd-skipped related 1; odz (odd oz/ten-m) related 1. [refseq;acc:nm_145260]	OSR1	High confidence	274.027	237.79	1.15239
	testis specific, 10. [refseq;acc:nm_025244]	TSGA10	Low confidence	196.373	206.946	1.05384
185	adiponectin receptor 2. [refseq;acc:nm_024551]	ADIPOR2	High confidence	281.582	246.371	1.14292
	f-actin capping protein alpha-2 subunit (capz alpha-2). [swissprot;acc:p47755]	no value	Low confidence	212.589	201.755	1.0537
186	associated molecule with the sh3 domain of stam. [refseq;acc:nm_006463]	STAMBP		196.381	206.921	1.05367
	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	FLNB	High confidence	226.582	198.444	1.14179
187	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]	REV1
	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	no value	Low confidence	189.373	179.829	1.05307

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.