MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

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Showing element 3151 to 3200 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	red	network_comparison	green
m-phase inducer phosphatase 2 (ec 3.1.3.48) (dual specificity phosphatase cdc25b). [swissprot;acc:p30305]	1530	CDC25B	Subtracted	260.269	3.738	256.531
	1642		Divided		1.01457
m-phase inducer phosphatase 3 (ec 3.1.3.48) (dual specificity phosphatase cdc25c). [swissprot;acc:p30307]	1321	CDC25C	Subtracted	259.439	4.642	254.797
	1504		Divided		1.01822
mab-21-like protein 1; mab-21-like 1. [refseq;acc:nm_005584]	2786	MAB21L1		0.00001	1	0.00001
			Subtracted	0	0	0
mab-21-like protein 2; mab-21-like 2. [refseq;acc:nm_006439]	2783	MAB21L2	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
mad protein (max dimerizer). [swissprot;acc:q05195]	252	MXD1		228	23.667	204.333
	253		Divided		1.11583
mago nashi protein homolog. [swissprot;acc:p50606]	2864	MAGOH		0.00001	1	0.00001
			Subtracted	0	0	0
maguk p55 subfamily member 2 (mpp2 protein) (discs, large homolog 2). [swissprot;acc:q14168]	1381	MPP2		228.513	4.47	232.983
	1467		Divided		1.01956
maguk p55 subfamily member 3 (mpp3 protein) (discs, large homolog 3). [swissprot;acc:q13368]	2070	MPP3	Subtracted	218.124	1.691	216.433
	2088		Divided		1.00781
maguk p55 subfamily member 6 (veli-associated maguk 1) (vam-1). [swissprot;acc:q9nzw5]	1399	MPP6	Subtracted	228.469	4.386	232.855
	1479		Divided		1.0192
major centromere autoantigen b (centromere protein b) (cenp-b). [swissprot;acc:p07199]	3013	CENPB		0.00001	1	0.00001
			Subtracted	0	0	0
malate dehydrogenase, cytoplasmic (ec 1.1.1.37). [swissprot;acc:p40925]	3213	MDH1	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
malate dehydrogenase, mitochondrial precursor (ec 1.1.1.37). [swissprot;acc:p40926]	487	MDH2		238.529	15.57	254.099
	571		Divided		1.06528
maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708]	806	GSTZ1	Subtracted	267.447	9.326	276.773
	954		Divided		1.03487
malonyl-coa decarboxylase, mitochondrial precursor (ec 4.1.1.9) (mcd). [swissprot;acc:o95822]	1634	MLYCD		215.772	1.01494	212.596
	1636		Subtracted		3.176
mam domain containing glycosylphosphatidylinositol anchor 1; glycosyl-phosphatidyl-inositol-mam. [refseq;acc:nm_153487]	3070	MDGA1	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
mannose-6-phosphate isomerase (ec 5.3.1.8) (phosphomannose isomerase) (pmi) (phosphohexomutase). [swissprot;acc:p34949]	1502	MPI		219.306	3.873	223.179
	1522		Divided		1.01766
mannose-p-dolichol utilization defect 1 protein (suppressor of lec15 and lec35 glycosylation mutation homolog) (sl15). [swissprot;acc:o75352]	911	MPDU1	Subtracted	225.955	7.94	218.015
	929		Divided		1.03642
mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	2	no value		15	1.86667	28
	578		Subtracted		13
map kinase-activated protein kinase 2 (ec 2.7.1.-) (mapk-activated protein kinase 2) (mapkap kinase 2) (mapkapk-2). [swissprot;acc:p49137]	1267	MAPKAPK2	Divided	171.231	1.02425	167.177
	1465		Subtracted		4.054
map/microtubule affinity-regulating kinase 1. [refseq;acc:nm_018650]	842	MARK1		236.741	8.806	245.547
	922		Divided		1.0372
map/microtubule affinity-regulating kinase 2 isoform b; elkl motif kinase 1; elkl motif kinase. [refseq;acc:nm_004954]	843	MARK2	Subtracted		8.806
	923		Divided		1.0372
maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]	758	no value	Subtracted	224.244	10.267	234.511
	792		Divided		1.04578
mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]	508	CPA3		177.698	1.07058	190.24
	616		Subtracted		12.542
mawd binding protein (unknown protein 32 from 2d-page of liver tissue). [swissprot;acc:p30039]	2411	PBLD	Divided	194.407	1.00362	193.706
	2442		Subtracted		0.701
max dimerization protein 3; likely ortholog of mouse max dimerization protein 3. [refseq;acc:nm_031300]	256	RAB24		227.999	23.629	204.37
	259		Divided		1.11562

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.