MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 312 to 361 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
156	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	RGS20	Divided	249.663	298.263	1.19466
157	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]	NEUROD2	Subtracted	312	284	28
	transcription factor lbx1. [swissprot;acc:p52954]	LBX1	Divided	249.663	298.263	1.19466
158	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]	CHD3	Subtracted	312	284	28
	mosaic protein lgn. [swissprot;acc:p81274]	GPSM2	Divided	249.663	298.263	1.19466
159	doc-1 related protein (doc-1r). [swissprot;acc:o75956]	CDK2AP2	Subtracted	312	284	28
	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	RGS17	Divided	249.663	298.263	1.19466
160	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	GNAO1
	neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]	NEUROD6	Subtracted	312	284	28
161	neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]	NEUROD1
	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	RAP1GAP	Divided	249.663	298.263	1.19466
162	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	no value	Subtracted	142	170	28
	nostrin. [refseq;acc:nm_052946]	NOSTRIN	Divided	209.299	249.187	1.19058
163	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	ARRB2	Subtracted	133	105	28
	eap30 subunit of ell complex. [refseq;acc:nm_007241]	SNF8	Divided	209.299	249.187	1.19058
164	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	ARRB1	Subtracted	133	105	28
	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	SLC39A6	Divided	209.299	249.187	1.19058
165	glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]	GAD2
	spermatogenesis associated 6. [refseq;acc:nm_019073]	SPATA6	Subtracted	133	105	28
166	gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [swissprot;acc:q99747]	NAPG	Divided	209.299	249.187	1.19058
	neurogenic differentiation factor 4 (neurod4). [swissprot;acc:q9hd90]	NEUROD4	Subtracted	312	284	28
167	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]	AMPD2		133	105
	glutamate decarboxylase, 67 kda isoform (ec 4.1.1.15) (gad-67) (67 kda glutamic acid decarboxylase). [swissprot;acc:q99259]	GAD1	Divided	209.299	249.187	1.19058
168	chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557]	CHD5	Subtracted	312	284	28
	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	no value	Divided	82.5916	98.0548	1.18722
169	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	ATG3
	cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1) (putative oral cancer suppressor) (deleted in oral cancer- 1) (doc-1). [swissprot;acc:o14519]	CDK2AP1	Subtracted	312	284	28
170	huntingtin interacting protein c. [refseq;acc:nm_012272]	PRPF40B		227.971	200.417	27.554
	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483]	TIA1	Divided	227.199	192.715	1.17894
171	nucleolysin tiar (tia-1 related protein). [swissprot;acc:q01085]	TIAL1		227.202	192.823	1.17829
	short transient receptor potential channel 4 (trpc4) (trp-related protein 4) (htrp-4) (htrp4). [swissprot;acc:q9ubn4]	TRPC4	Subtracted	201.478	228.784	27.306
172	cg9578-like; yeast ypr037w and worm c02c2.6 predicted proteins-like. [refseq;acc:nm_152902]	TIPRL	Divided	174.667	205.556	1.17685
	ebp50-pdz interactor of 64 kda (epi64 protein). [swissprot;acc:q9bxi6]	TBC1D10A	Subtracted	201.515	228.752	27.237
173	short transient receptor potential channel 5 (trpc5) (htrp-5) (htrp5). [swissprot;acc:q9ul62]	TRPC5
	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641]	SNRPD1	Divided	227.032	193.056	1.17599
174	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	DGCR14		335	286	1.17133
	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	LUC7L2	Subtracted	228.1	200.968	27.132
175	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]	COPS3	Divided	199.949	234.187	1.17123
	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	LUC7L	Subtracted	228.085	201.006	27.079
176	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]	POLE4	Divided	275.754	235.908	1.1689
	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]	EIF5	Subtracted	271.016	244.167	26.849
177	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	NCBP2L	Divided	229.406	196.695	1.1663
	transcriptional co-repressor sin3a; transcriptional regulator, sin3a (yeast). [refseq;acc:nm_015477]	SIN3A	Subtracted	241.07	267.88	26.81
178	density-regulated protein (drp) (drp1 protein) (smooth muscle cell associated protein-3) (smap-3). [swissprot;acc:o43583]	DENR
	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	no value	Divided	226.887	194.72	1.1652
179	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]			226.884	194.79	1.16476
	phenylalanine-4-hydroxylase (ec 1.14.16.1) (pah) (phe-4- monooxygenase). [swissprot;acc:p00439]	PAH	Subtracted	227.357	254.15	26.793
180	pp3111 protein. [refseq;acc:nm_022156]	DUS1L
	tar dna-binding protein-43 (tdp-43). [swissprot;acc:q13148]	TARDBP	Divided	256.228	298.438	1.16474
181	b9 protein; likely ortholog of mouse endothelial precursor protein b9. [refseq;acc:nm_015681]	B9D1		229.818	267.265	1.16294

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.