MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	description	Hugo	Value Type	Network Comparison Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 3101 to 3150 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
1551	adp,atp carrier protein, heart/skeletal muscle isoform t1 (adp/atp translocase 1) (adenine nucleotide translocator 1) (ant 1). [swissprot;acc:p12235]	SLC25A4	Divided	225.159	221.424	1.01687
	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	no value	Subtracted	221.128	224.767	3.639
1552	adp,atp carrier protein, fibroblast isoform (adp/atp translocase 2) (adenine nucleotide translocator 2) (ant 2). [swissprot;acc:p05141]	SLC25A5	Divided	225.159	221.424	1.01687
	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	no value	Subtracted	221.128	224.767	3.639
1553	adenosylhomocysteinase (ec 3.3.1.1) (s-adenosyl-l-homocysteine hydrolase) (adohcyase). [swissprot;acc:p23526]	AHCY	Divided	215.389	211.833	1.01679
	protein c20orf45 (cgi-107). [swissprot;acc:q9y3b1]	SLMO2	Subtracted	221.128	224.767	3.639
1554	c-terminal binding protein 1 (ctbp1). [swissprot;acc:q13363]	CTBP1	Divided	196.215	193.018	1.01656
	eukaryotic translation initiation factor 3 subunit 6 interacting protein (hspc021/hspc025). [swissprot;acc:q9y262]	EIF3EIP	Subtracted	221.128	224.767	3.639
1555	pas domain containing serine/threonine kinase; pas-serine/threonine kinase. [refseq;acc:nm_015148]	PASK	Divided	196.192	192.996	1.01656
	putative rna-binding protein 7 (rna binding motif protein 7). [swissprot;acc:q9y580]	RBM7	Subtracted	221.128	224.767	3.639
1556	b-cell lymphoma 6 protein (bcl-6) (zinc finger protein 51) (laz-3 protein) (bcl-5). [swissprot;acc:p41182]	BCL6	Divided	196.192	192.996	1.01656
	valyl-trna synthetase 2 (ec 6.1.1.9) (valine--trna ligase 2) (valrs 2) (g7a). [swissprot;acc:p26640]	VARS	Subtracted	223.589	227.219	3.63
1557	adapter-related protein complex 1 beta 1 subunit (beta-adaptin 1) (adaptor protein complex ap-1 beta-1 subunit) (golgi adaptor ha1/ap1 adaptin beta subunit) (clathrin assembly protein complex 1 beta large chain). [swissprot;acc:q10567]	AP1B1		222.166	225.79	3.624
	zinc finger protein slug (neural crest transcription factor slug) (snail homolog 2). [swissprot;acc:o43623]	SNAI2	Divided	196.192	192.996	1.01656
1558	c-terminal binding protein 2 (ctbp2). [swissprot;acc:p56545]	CTBP2		196.171	192.977	1.01655
	fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917]	FIP1L1	Subtracted	115.817	119.432	3.615
1559	b-cell cll/lymphoma 6, member b (zinc finger protein); zinc finger protein 62. [refseq;acc:nm_181844]	BCL6B	Divided	196.191	192.996	1.01655
	tata element modulatory factor (tmf). [swissprot;acc:p82094]	TMF1	Subtracted	222.585	218.982	3.603
1560	p66 alpha. [refseq;acc:nm_017660]	GATAD2A	Divided	167.687	170.455	1.01651
	scy1-like 1; telomerase regulation-associated protein; ht019 protein; telomerase regulation-associated protein; n-terminal kinase-like protein; teratoma-associated tyrosine kinase; n-terminal kinase-like. [refseq;acc:nm_020680]	SCYL1	Subtracted	222.585	218.982	3.603
1561	nuclear pore complex protein nup98 (nucleoporin nup98) (98 kda nucleoporin). [swissprot;acc:p52948]	NUP98
	transcription repressor p66 beta component of the mecp1 complex. [refseq;acc:nm_020699]	GATAD2B	Divided	167.687	170.455	1.01651
1562	ammecr1 protein. [refseq;acc:nm_015365]	AMMECR1	Subtracted	222.585	218.982	3.603
	tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [swissprot;acc:p17735]	no value	Divided	167.687	170.455	1.01651
1563	atp synthase gamma chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p36542]	ATP5C1		218.277	214.739	1.01648
	mrna-associated protein mrnp 41 (rae1 protein homolog). [swissprot;acc:p78406]	RAE1	Subtracted	222.585	218.982	3.603
1564	adapter-related protein complex 1 gamma 2 subunit (gamma2-adaptin) (adaptor protein complex ap-1 gamma-2 subunit) (g2ad). [swissprot;acc:o75843]	JPH4		222.133	225.731	3.598
	atp synthase oligomycin sensitivity conferral protein, mitochondrial precursor (ec 3.6.3.14) (oscp). [swissprot;acc:p48047]	ATP5O	Divided	218.277	214.739	1.01648
1565	adapter-related protein complex 1 sigma 1b subunit (sigma-adaptin 1b) (adaptor protein complex ap-1 sigma-1b subunit) (golgi adaptor ha1/ap1 adaptin sigma-1b subunit) (clathrin assembly protein complex 1 sigma- 1b small chain) (sigma 1b subunit of ap-1 clathrin) (dc22). [swissprot;acc:p56377]	no value	Subtracted	222.134	225.731	3.597
	eukaryotic translation initiation factor 3 subunit 11 (eif-3 p25) (eif3k) (muscle specific gene m9 protein) (ptd001) (hspc029) (arg134). [swissprot;acc:q9ubq5]	EIF3K	Divided	221.128	224.767	1.01646
1566	adapter-related protein complex 1 gamma 1 subunit (gamma-adaptin) (adaptor protein complex ap-1 gamma-1 subunit) (golgi adaptor ha1/ap1 adaptin gamma-1 subunit) (clathrin assembly protein complex 1 gamma-1 large chain). [swissprot;acc:o43747]	AP1G1	Subtracted	222.134	225.731	3.597
	erythroid differentiation and denucleation factor 1. [swissprot;acc:o60584]	SLMO1	Divided	221.128	224.767	1.01646
1567	adapter-related protein complex 1 sigma 1c subunit (sigma-adaptin 1c) (adaptor protein complex ap-1 sigma-1c subunit) (golgi adaptor ha1/ap1 adaptin sigma-1c subunit) (clathrin assembly protein complex 1 sigma- 1c small chain) (sigma 1c subunit of ap-1 clathrin). [swissprot;acc:q96pc3]	AP1S3	Subtracted	222.134	225.731	3.597
	bardet-biedl syndrome 7 protein isoform a; bbs2-like 1. [refseq;acc:nm_176824]	BBS7	Divided	221.128	224.767	1.01646
1568	adapter-related protein complex 1 sigma 1a subunit (sigma-adaptin 1a) (adaptor protein complex ap-1 sigma-1a subunit) (golgi adaptor ha1/ap1 adaptin sigma-1a subunit) (clathrin assembly protein complex 1 sigma- 1a small chain) (clathrin coat assembly protein ap19) (ha1 19 kda subunit) (sigma 1a subunit of ap-1 clathrin). [swissprot;acc:q00382]	AP1S1	Subtracted	222.134	225.731	3.597
	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	no value	Divided	221.128	224.767	1.01646
1569	glycogen [starch] synthase, muscle (ec 2.4.1.11). [swissprot;acc:p13807]	GYS1	Subtracted	159.75	156.153	3.597
	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	no value	Divided	221.128	224.767	1.01646
1570	endo-beta-n-acetylglucosaminidase. [refseq;acc:nm_022759]		Subtracted	159.86	156.275	3.585
	protein c20orf45 (cgi-107). [swissprot;acc:q9y3b1]	SLMO2	Divided	221.128	224.767	1.01646
1571	eukaryotic translation initiation factor 3 subunit 6 interacting protein (hspc021/hspc025). [swissprot;acc:q9y262]	EIF3EIP
	trimethyllysine dioxygenase, mitochondrial precursor (ec 1.14.11.8) (epsilon-trimethyllysine 2-oxoglutarate dioxygenase) (tml-alpha- ketoglutarate dioxygenase) (tml hydroxylase) (tml dioxygenase) (tmld). [swissprot;acc:q9nvh6]	TMLHE	Subtracted	213.546	209.965	3.581
1572	gtp-binding protein era homolog (hera) (fragment). [swissprot;acc:o75616]	ERAL1
	putative rna-binding protein 7 (rna binding motif protein 7). [swissprot;acc:q9y580]	RBM7	Divided	221.128	224.767	1.01646
1573	cleavage stimulation factor subunit 3; cleavage stimulation factor, 3' pre-rna, subunit 3, 77kd. [refseq;acc:nm_001326]	CSTF3	Subtracted	121.428	125.004	3.576
	r3h domain protein 1. [swissprot;acc:q15032]	R3HDM1	Divided	218.105	214.573	1.01646
1574	glycogen [starch] synthase, liver (ec 2.4.1.11). [swissprot;acc:p54840]	GYS2	Subtracted	159.993	156.421	3.572
	tata element modulatory factor (tmf). [swissprot;acc:p82094]	TMF1	Divided	222.585	218.982	1.01645
1575	adapter-related protein complex 2 beta 1 subunit (beta-adaptin) (plasma membrane adaptor ha2/ap2 adaptin beta subunit) (clathrin assembly protein complex 2 beta large chain) (ap105b). [swissprot;acc:p21851]	AP2B1	Subtracted	222.103	225.675	3.572
	scy1-like 1; telomerase regulation-associated protein; ht019 protein; telomerase regulation-associated protein; n-terminal kinase-like protein; teratoma-associated tyrosine kinase; n-terminal kinase-like. [refseq;acc:nm_020680]	SCYL1	Divided	222.585	218.982	1.01645

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.