MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

description	Gene	Rank	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 3101 to 3150 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	Value Type	red	green	network_comparison
band 4.1-like protein 1 (neuronal protein 4.1) (4.1n). [swissprot;acc:q9h4g0]	1582	EPB41L1	Subtracted	Rooted	70.2384	72.4912	2.2528
	1734		Divided				1.03207
	2144			Ranked	206.443	207.864	1.00688
	2163		Subtracted				1.421
band 4.1-like protein 2 (generally expressed protein 4.1) (4.1g). [swissprot;acc:o43491]	229	EPB41L2		Squared	45986	56776.1	10790.1
	373		Divided				1.23464
	580		Subtracted	Measured	7813.36	8569.97	756.61
	971		Divided				1.09684
	1580		Subtracted	Rooted	70.2384	72.4914	2.253
	1732		Divided				1.03208
	2146			Ranked	206.443	207.864	1.00688
	2164		Subtracted				1.421
band 4.1-like protein 3 (4.1b) (differentially expressed in adenocarcinoma of the lung protein 1) (dal-1). [swissprot;acc:q9y2j2]	228	EPB41L3		Squared	45986.7	56776.8	10790.1
	372		Divided				1.23464
	577		Subtracted	Measured	7813.45	8570.07	756.62
	970		Divided				1.09684
	1579		Subtracted	Rooted	70.2389	72.4919	2.253
	1731		Divided				1.03208
	2145			Ranked	206.442	207.862	1.00688
	2166		Subtracted				1.42
bardet-biedl syndrome 7 protein isoform a; bbs2-like 1. [refseq;acc:nm_176824]	1550	BBS7			221.128	224.767	3.639
	1567		Divided				1.01646
	1928		Subtracted	Squared	22746.3	24873.5	2127.2
	1936		Divided				1.09352
	2129			Measured	5328.73	5616.59	1.05402
	2176		Subtracted				287.86
	2464		Divided	Rooted	59.9326	60.6973	1.01276
	2478		Subtracted				0.7647
barrier-to-autointegration factor (breakpoint cluster region protein 1). [swissprot;acc:o75531]	2804	BANF1	Divided	Measured	0.00001	0.00001	1
				Ranked
				Squared
				Rooted
			Subtracted	Measured	0	0	0
				Ranked
				Squared
				Rooted
basic helix-loop-helix domain containing, class b, 5; trinucleotide repeat containing 20. [refseq;acc:nm_152414]	209	BHLHB5		Squared	62757.7	50767.8	11989.9
	309			Measured	11848.8	10770.3	1078.5
	367		Divided	Squared	62757.7	50767.8	1.23617
	908			Measured	11848.8	10770.3	1.10014
	933			Ranked	159.165	164.951	1.03635
	953		Subtracted	Rooted	93.2947	89.7137	3.581
	1111			Ranked	159.165	164.951	5.786
	1392		Divided	Rooted	93.2947	89.7137	1.03992
basic proline-rich peptide p-e (ib-9). [swissprot;acc:p02811]	1739	no value	Subtracted	Squared	31216.4	33543.2	2326.8
	1751			Measured	6262.66	6652.85	390.19
	1920		Divided				1.0623
	1934		Subtracted	Rooted	63.7832	65.5999	1.8167
	1952		Divided				1.02848
	2345			Squared	31216.4	33543.2	1.07454

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.