MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	Hugo	Value Type	description	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 32 to 81 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Network Comparison Type	Hugo	description	Interaction Map	red	network_comparison	green
8	Subtracted	JPH3	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	High confidence	288	74	362
9	Divided	MRPS17	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Low confidence	58	1.31818	44
		XAB1	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	High confidence	212	1.45755	309
	Subtracted	JPH2	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]		288	74	362
		TMEM132A	gbp protein isoform a. [refseq;acc:nm_017870]	Low confidence	305.399	58.186	247.213
10	Divided	ATPBD1C	protein x 0004. [refseq;acc:nm_016301]	High confidence	212	1.45755	309
		SLC25A43	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Low confidence	58	1.31818	44
	Subtracted	JMJD1A	jumonji domain containing 1; zinc finger protein; testis-specific protein a. [refseq;acc:nm_018433]		305.303	58.134	247.169
		SMPD2	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	High confidence	288	74	362
11	Divided	BEST1	bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]	Low confidence	37.318	1.30966	28.4944
		RINT1	rad50-interacting protein 1. [refseq;acc:nm_021930]	High confidence	337	1.45259	232
	Subtracted	PRSS3	trypsin iii precursor (ec 3.4.21.4) (brain trypsinogen) (mesotrypsinogen) (trypsin iv). [swissprot;acc:p35030]	Low confidence	304.548	57.724	246.824
		TMEM33	db83 protein. [swissprot;acc:p57088]	High confidence	288	74	362
12	Divided	BEST4	vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274]	Low confidence	37.3475	1.30933	28.5242
		RHOBTB2	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	High confidence	337	1.45259	232
	Subtracted	no value	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]		266.856	69.377	336.233
		PRSS1	trypsin i precursor (ec 3.4.21.4) (cationic trypsinogen). [swissprot;acc:p07477]	Low confidence	304.359	57.622	246.737
13	Divided	no value	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]		37.9984	1.30207	29.1831
		UFC1	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	High confidence	288.754	1.3585	212.554
	Subtracted	GNG12	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]		266.856	69.377	336.233
		UFC1	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	Low confidence	255.046	52.684	202.362
14	Divided	ATG4A	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	High confidence	56.6768	1.32952	75.3531
		BEST2	vitelliform macular dystrophy 2-like protein 1. [refseq;acc:nm_017682]	Low confidence	37.9984	1.30207	29.1831
	Subtracted	CYP27B1	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]		286.396	47.92	238.476
		GNG4	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	High confidence	266.863	69.328	336.191
15	Divided	MAP1LC3B	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]		56.7244	1.32914	75.3948
		UFC1	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	Low confidence	255.046	1.26035	202.362
	Subtracted	CYP27A1	cytochrome p450 27, mitochondrial precursor (ec 1.14.-.-) (cytochrome p-450c27/25) (sterol 26-hydroxylase) (sterol 27-hydroxylase) (vitamin d(3) 25-hydroxylase) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase). [swissprot;acc:q02318]		286.347	47.893	238.454
		GNG3	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	High confidence	266.863	69.327	336.19
16	Divided	JMJD1C	thyroid receptor interacting protein 8 (trip-8) (fragment). [swissprot;acc:q15652]	Low confidence	305.472	1.2355	247.246
		MAP1LC3A	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	High confidence	56.7252	1.32913	75.3954
	Subtracted	CYP24A1	cytochrome p450 24a1, mitochondrial precursor (ec 1.14.-.-) (p450- cc24) (vitamin d(3) 24-hydroxylase) (1,25-dihydroxyvitamin d(3) 24- hydroxylase) (24-ohase). [swissprot;acc:q07973]	Low confidence	284.798	47.055	237.743
		GNG8	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	High confidence	266.864	69.32	336.184
17	Divided	ATG4B	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]		56.7841	1.32866	75.447
		TMEM132A	gbp protein isoform a. [refseq;acc:nm_017870]	Low confidence	305.399	1.23537	247.213
	Subtracted	BOK	bcl2-related ovarian killer. [refseq;acc:nm_032515]		265.638	42.403	223.235
		GNG5	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	High confidence	266.864	69.318	336.182
18	Divided	GBE1	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]		185.678	1.32082	245.247
		JMJD1A	jumonji domain containing 1; zinc finger protein; testis-specific protein a. [refseq;acc:nm_018433]	Low confidence	305.303	1.2352	247.169
	Subtracted	GNG10	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	High confidence	266.865	69.316	336.181
		PRKRAP1	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	Low confidence	273.188	40.698	232.49
19	Divided	PRSS3	trypsin iii precursor (ec 3.4.21.4) (brain trypsinogen) (mesotrypsinogen) (trypsin iv). [swissprot;acc:p35030]		304.548	1.23387	246.824
		PYGB	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	High confidence	185.678	1.32082	245.247
	Subtracted	no value	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]		266.865	69.313	336.178
		HINT1	histidine triad nucleotide-binding protein 1 (adenosine 5'- monophosphoramidase) (protein kinase c inhibitor 1) (protein kinase c- interacting protein 1) (pkci-1). [swissprot;acc:p49773]	Low confidence	188.298	40.211	228.509
20	Divided	PRSS1	trypsin i precursor (ec 3.4.21.4) (cationic trypsinogen). [swissprot;acc:p07477]		304.359	1.23354	246.737
		PYGL	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]	High confidence	185.678	1.32082	245.247
	Subtracted	GNG11	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]		266.868	69.291	336.159
		TOB2	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	Low confidence	297.273	38.683	258.59
21	Divided	MYO15A	myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]	High confidence	185.678	1.32082	245.247

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.