MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 3075 to 3124 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
1538	ELAC2	elac homolog 2; putative prostate cancer susceptibility protein; elac (e. coli) homolog 2. [refseq;acc:nm_018127]	Divided	228.419	232.376	1.01732
	MYBL2	myb-related protein b (b-myb). [swissprot;acc:p10244]	Subtracted	222.541	218.823	3.718
1539	MYBL1	myb-related protein a (a-myb). [swissprot;acc:p10243]		222.512	218.802	3.71
	RBM5	rna-binding protein 5 (rna binding motif protein 5) (putative tumor suppressor luca15) (g15 protein). [swissprot;acc:p52756]	Divided	228.419	232.376	1.01732
1540	ASS1	argininosuccinate synthase (ec 6.3.4.5) (citrulline--aspartate ligase). [swissprot;acc:p00966]	Subtracted	217.769	221.474	3.705
	ATG5	autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0]	Divided	240.077	236.015	1.01721
1541	CSE1L	importin-alpha re-exporter (chromosome segregation 1-like protein) (cellular apoptosis susceptibility protein). [swissprot;acc:p55060]	Subtracted	192.336	188.637	3.699
	MYB	myb proto-oncogene protein (c-myb). [swissprot;acc:p10242]	Divided	222.672	218.92	1.01714
1542	NR2E1	orphan nuclear receptor nr2e1 (nuclear receptor tlx) (tailless homolog) (tll) (htll). [swissprot;acc:q9y466]	Subtracted	219.762	216.081	3.681
	TMLHE	trimethyllysine dioxygenase, mitochondrial precursor (ec 1.14.11.8) (epsilon-trimethyllysine 2-oxoglutarate dioxygenase) (tml-alpha- ketoglutarate dioxygenase) (tml hydroxylase) (tml dioxygenase) (tmld). [swissprot;acc:q9nvh6]	Divided	213.546	209.965	1.01706
1543	ERAL1	gtp-binding protein era homolog (hera) (fragment). [swissprot;acc:o75616]
	NR2C1	orphan nuclear receptor tr2. [swissprot;acc:p13056]	Subtracted	219.76	216.083	3.677
1544	NR2E1	orphan nuclear receptor nr2e1 (nuclear receptor tlx) (tailless homolog) (tll) (htll). [swissprot;acc:q9y466]	Divided	219.762	216.081	1.01704
	TYMS	thymidylate synthase (ec 2.1.1.45) (ts) (tsase). [swissprot;acc:p04818]	Subtracted	225.119	228.769	3.65
1545	no value	dihydrofolate reductase (ec 1.5.1.3). [swissprot;acc:p00374]
	NR2C1	orphan nuclear receptor tr2. [swissprot;acc:p13056]	Divided	219.76	216.083	1.01702
1546	ASS1	argininosuccinate synthase (ec 6.3.4.5) (citrulline--aspartate ligase). [swissprot;acc:p00966]		217.769	221.474	1.01701
	SDF2	stromal cell-derived factor 2 precursor (sdf-2). [swissprot;acc:q99470]	Subtracted	225.119	228.769	3.65
1547	MYBL2	myb-related protein b (b-myb). [swissprot;acc:p10244]	Divided	222.541	218.823	1.01699
	SDF2L1	stromal cell-derived factor 2-like protein 1 precursor (sdf2 like protein 1) (pwp1-interacting protein 8). [swissprot;acc:q9hcn8]	Subtracted	225.119	228.769	3.65
1548	EIF3K	eukaryotic translation initiation factor 3 subunit 11 (eif-3 p25) (eif3k) (muscle specific gene m9 protein) (ptd001) (hspc029) (arg134). [swissprot;acc:q9ubq5]		221.128	224.767	3.639
	MYBL1	myb-related protein a (a-myb). [swissprot;acc:p10243]	Divided	222.512	218.802	1.01696
1549	DCTN2	dynactin complex 50 kda subunit (50 kda dynein-associated polypeptide) (dynamitin) (dctn-50) (dynactin 2). [swissprot;acc:q13561]		225.159	221.424	1.01687
	SLMO1	erythroid differentiation and denucleation factor 1. [swissprot;acc:o60584]	Subtracted	221.128	224.767	3.639
1550	BBS7	bardet-biedl syndrome 7 protein isoform a; bbs2-like 1. [refseq;acc:nm_176824]
	SLC25A6	adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236]	Divided	225.159	221.424	1.01687
1551	no value	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	Subtracted	221.128	224.767	3.639
	SLC25A4	adp,atp carrier protein, heart/skeletal muscle isoform t1 (adp/atp translocase 1) (adenine nucleotide translocator 1) (ant 1). [swissprot;acc:p12235]	Divided	225.159	221.424	1.01687
1552	no value	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	Subtracted	221.128	224.767	3.639
	SLC25A5	adp,atp carrier protein, fibroblast isoform (adp/atp translocase 2) (adenine nucleotide translocator 2) (ant 2). [swissprot;acc:p05141]	Divided	225.159	221.424	1.01687
1553	AHCY	adenosylhomocysteinase (ec 3.3.1.1) (s-adenosyl-l-homocysteine hydrolase) (adohcyase). [swissprot;acc:p23526]		215.389	211.833	1.01679
	SLMO2	protein c20orf45 (cgi-107). [swissprot;acc:q9y3b1]	Subtracted	221.128	224.767	3.639
1554	CTBP1	c-terminal binding protein 1 (ctbp1). [swissprot;acc:q13363]	Divided	196.215	193.018	1.01656
	EIF3EIP	eukaryotic translation initiation factor 3 subunit 6 interacting protein (hspc021/hspc025). [swissprot;acc:q9y262]	Subtracted	221.128	224.767	3.639
1555	PASK	pas domain containing serine/threonine kinase; pas-serine/threonine kinase. [refseq;acc:nm_015148]	Divided	196.192	192.996	1.01656
	RBM7	putative rna-binding protein 7 (rna binding motif protein 7). [swissprot;acc:q9y580]	Subtracted	221.128	224.767	3.639
1556	BCL6	b-cell lymphoma 6 protein (bcl-6) (zinc finger protein 51) (laz-3 protein) (bcl-5). [swissprot;acc:p41182]	Divided	196.192	192.996	1.01656
	VARS	valyl-trna synthetase 2 (ec 6.1.1.9) (valine--trna ligase 2) (valrs 2) (g7a). [swissprot;acc:p26640]	Subtracted	223.589	227.219	3.63
1557	AP1B1	adapter-related protein complex 1 beta 1 subunit (beta-adaptin 1) (adaptor protein complex ap-1 beta-1 subunit) (golgi adaptor ha1/ap1 adaptin beta subunit) (clathrin assembly protein complex 1 beta large chain). [swissprot;acc:q10567]		222.166	225.79	3.624
	SNAI2	zinc finger protein slug (neural crest transcription factor slug) (snail homolog 2). [swissprot;acc:o43623]	Divided	196.192	192.996	1.01656
1558	CTBP2	c-terminal binding protein 2 (ctbp2). [swissprot;acc:p56545]		196.171	192.977	1.01655
	FIP1L1	fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917]	Subtracted	115.817	119.432	3.615
1559	BCL6B	b-cell cll/lymphoma 6, member b (zinc finger protein); zinc finger protein 62. [refseq;acc:nm_181844]	Divided	196.191	192.996	1.01655
	TMF1	tata element modulatory factor (tmf). [swissprot;acc:p82094]	Subtracted	222.585	218.982	3.603
1560	GATAD2A	p66 alpha. [refseq;acc:nm_017660]	Divided	167.687	170.455	1.01651
	SCYL1	scy1-like 1; telomerase regulation-associated protein; ht019 protein; telomerase regulation-associated protein; n-terminal kinase-like protein; teratoma-associated tyrosine kinase; n-terminal kinase-like. [refseq;acc:nm_020680]	Subtracted	222.585	218.982	3.603
1561	GATAD2B	transcription repressor p66 beta component of the mecp1 complex. [refseq;acc:nm_020699]	Divided	167.687	170.455	1.01651
	NUP98	nuclear pore complex protein nup98 (nucleoporin nup98) (98 kda nucleoporin). [swissprot;acc:p52948]	Subtracted	222.585	218.982	3.603
1562	no value	tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [swissprot;acc:p17735]	Divided	167.687	170.455	1.01651
	AMMECR1	ammecr1 protein. [refseq;acc:nm_015365]	Subtracted	222.585	218.982	3.603

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.