MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Rank	Network Comparison Type	Hugo	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 3075 to 3124 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Network Comparison Type	Hugo	red	green	network_comparison
lim domain binding 1; carboxy terminal lim domain protein 2; lim domain-binding factor-1. [refseq;acc:nm_003893]	1897	Divided	no value	199.883	197.835	1.01035
	1959	Subtracted				2.048
lim domain binding 2; lim binding domain 2; lim domain-binding factor-2. [refseq;acc:nm_001290]	1896	Divided	LDB2			1.01035
	1958	Subtracted				2.048
lim domain only 7; zinc-finger domain-containing protein; lomp protein; f-box only protein 20; f-box protein fbx20. [refseq;acc:nm_005358]	2095		LMO7	216.23	217.801	1.571
	2107	Divided				1.00727
lim domain protein, cardiac (muscle lim protein) (cysteine-rich protein 3) (crp3). [swissprot;acc:p50461]	147	Subtracted	CSRP3	239.32	267.842	28.522
	233	Divided				1.11918
lim homeobox transcription factor 1 alpha (lim/homeobox protein lmx1a) (lim-homeobox protein 1.1) (lmx-1.1). [swissprot;acc:q8te12]	2609		LMX1A	215.497	215.799	1.0014
	2615	Subtracted				0.302
lim homeobox transcription factor 1 beta (lim/homeobox protein lmx1b) (lim-homeobox protein 1.2) (lmx-1.2). [swissprot;acc:o60663]	2611	Divided	LMX1B			1.0014
	2621	Subtracted				0.302
lim protein (similar to rat protein kinase c-binding enigma); enigma homolog. [refseq;acc:nm_006457]	1922		PDLIM5	219.25	217.175	2.075
	1983	Divided				1.00955
lim/homeobox protein lhx3. [swissprot;acc:q9ubr4]	1899		LHX3	199.884	197.837	1.01035
	1963	Subtracted				2.047
lim/homeobox protein lhx4. [swissprot;acc:q969g2]	1898	Divided	LHX4	199.881	197.833	1.01035
	1962	Subtracted				2.048
limb region 1 protein; limb region 1. [refseq;acc:nm_022458]	2434		LMBR1	235.812	235.088	0.724
	2469	Divided				1.00308
limbic system-associated membrane protein precursor (lsamp). [swissprot;acc:q13449]	1433	Subtracted	LSAMP	224.354	220.15	4.204
	1482	Divided				1.0191
limkain b1. [refseq;acc:nm_019081]	702	Subtracted	KIAA0430	220.438	209.118	11.32
	703	Divided				1.05413
limkain beta 2. [refseq;acc:nm_025140]	2086	Subtracted	CCDC92	217.723	216.089	1.634
	2096	Divided				1.00756
lin-7 homolog a; vertebrate lin7 homolog 1; tax interaction protein 33; mammalian lin-7 1. [refseq;acc:nm_004664]	1916	Subtracted	LIN7A	225.022	222.9	2.122
	1987	Divided				1.00952
lin-7 homolog b; lin-7b protein; likely ortholog of mouse lin-7b; mammalian lin-7 protein 2; likely orholog of mouse lin 7 homolog b (c. elegans). [refseq;acc:nm_022165]	1923	Subtracted	LIN7B	225.02	222.948	2.072
	2001	Divided				1.00929
lin-7 homolog c; lin-7 protein 3. [refseq;acc:nm_018362]	1985	Subtracted	LIN7C	225.015	223.041	1.974
	2027	Divided				1.00885
lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (ec 2.3.1.-) (e2) (dihydrolipoamide branched chain transacylase) (bckad e2 subunit). [swissprot;acc:p11182]	2582		DBT	213.422	213.75	1.00154
		Subtracted				0.328
lipoate-protein ligase, mitochondrial precursor (ec 6.-.-.-) (lipoate biosynthesis protein) (lipoyl ligase) (lipoyltransferase). [swissprot;acc:q9y234]	1738	Divided	LIPT1	206.595	209.258	1.01289
	1762	Subtracted				2.663
lipocalin-interacting membrane receptor. [refseq;acc:nm_018113]	2430		LMBR1L	235.812	235.088	0.724
	2465	Divided				1.00308
lipoic acid synthetase, mitochondrial (lip-syn) (lipoate synthase) (hussy-01) (fragment). [swissprot;acc:o43766]	1347		LIAS	204.961	209.517	1.02223
	1355	Subtracted				4.556
lipopolysaccharide-binding protein precursor (lbp). [swissprot;acc:p18428]	713		LBP	224.434	235.583	11.149
	753	Divided				1.04968
lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	1552	Subtracted	no value	221.128	224.767	3.639
	1569	Divided				1.01646
liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	108	Subtracted	SLC39A6	209.299	249.187	39.888
	164	Divided				1.19058
loh1cr12. [refseq;acc:nm_058169]	788	Subtracted	LOH12CR1	230.087	220.579	9.508
	827	Divided				1.0431
lon protease homolog, mitochondrial precursor (ec 3.4.21.-) (lon protease-like protein) (lonp) (lonhs). [swissprot;acc:p36776]	1768	Subtracted	no value	223.214	225.827	2.613
	1810	Divided				1.01171

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.