MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 308 to 357 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
154	RGS19	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	High confidence	249.663	298.263	1.19466
155	CTSL2	cathepsin l2 precursor (ec 3.4.22.43) (cathepsin v) (cathepsin u). [swissprot;acc:o60911]	Low confidence	211.818	199.734	1.0605
	RBM15	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	High confidence	249.663	298.263	1.19466
156	CTSL1	cathepsin l precursor (ec 3.4.22.15) (major excreted protein) (mep). [swissprot;acc:p07711]	Low confidence	211.808	199.761	1.06031
	RGS20	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	High confidence	249.663	298.263	1.19466
157	LBX1	transcription factor lbx1. [swissprot;acc:p52954]
	XKR7	dj310o13.4 (novel protein similar to predicted c. elegans and c. intestinalis proteins) (fragment). [sptrembl;acc:q9nug5]	Low confidence	178.507	168.371	1.0602
158	DNAJC8	dnaj homolog subfamily c member 8 (splicing protein spf31) (hspc315). [swissprot;acc:o75937]		219.838	207.417	1.05988
	GPSM2	mosaic protein lgn. [swissprot;acc:p81274]	High confidence	249.663	298.263	1.19466
159	GGNBP2	c3hc4-type zinc finger protein; likely ortholog of mouse dioxin inducible factor 3. [refseq;acc:nm_024835]	Low confidence	219.838	207.417	1.05988
	RGS17	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	High confidence	249.663	298.263	1.19466
160	APC	adenomatous polyposis coli protein (apc protein). [swissprot;acc:p25054]	Low confidence	222.31	235.538	1.0595
	GNAO1	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	High confidence	249.663	298.263	1.19466
161	APC2	adenomatous polyposis coli like. [refseq;acc:nm_005883]	Low confidence	222.34	235.547	1.0594
	RAP1GAP	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	High confidence	249.663	298.263	1.19466
162	DAD1	defender against cell death 1 (dad-1). [swissprot;acc:p46966]	Low confidence	197.99	186.913	1.05926
	NOSTRIN	nostrin. [refseq;acc:nm_052946]	High confidence	209.299	249.187	1.19058
163	SNF8	eap30 subunit of ell complex. [refseq;acc:nm_007241]
	VPS41	vacuolar assembly protein vps41 homolog (s53). [swissprot;acc:p49754]	Low confidence	202.698	191.393	1.05907
164	PPM1B	protein phosphatase 2c beta isoform (ec 3.1.3.16) (pp2c-beta). [swissprot;acc:o75688]		196.714	185.758	1.05898
	SLC39A6	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	High confidence	209.299	249.187	1.19058
165	CAPN1	calpain 1, large [catalytic] subunit (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (mu-type) (mucanp) (micromolar-calpain). [swissprot;acc:p07384]	Low confidence	222.508	210.345	1.05782
	GAD2	glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]	High confidence	209.299	249.187	1.19058
166	CAPN2	calpain 2, large [catalytic] subunit precursor (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (m-type) (m-calpain) (millimolar-calpain) (calpain large polypeptide l2). [swissprot;acc:p17655]	Low confidence	222.502	210.342	1.05781
	NAPG	gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [swissprot;acc:q99747]	High confidence	209.299	249.187	1.19058
167	GAD1	glutamate decarboxylase, 67 kda isoform (ec 4.1.1.15) (gad-67) (67 kda glutamic acid decarboxylase). [swissprot;acc:q99259]
	RHOBTB2	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Low confidence	212.695	201.131	1.05749
168	no value	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	High confidence	82.5916	98.0548	1.18722
	FER	proto-oncogene tyrosine-protein kinase fer (ec 2.7.1.112) (p94-fer) (c-fer). [swissprot;acc:p16591]	Low confidence	216.796	205.073	1.05717
169	ATG3	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	High confidence	82.5916	98.0548	1.18722
	RPL29	60s ribosomal protein l29 (cell surface heparin binding protein hip). [swissprot;acc:p47914]	Low confidence	216.79	205.07	1.05715
170	FES	proto-oncogene tyrosine-protein kinase fes/fps (ec 2.7.1.112) (c-fes). [swissprot;acc:p07332]		216.783	205.066	1.05714
	TIA1	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [swissprot;acc:p31483]	High confidence	227.199	192.715	1.17894
171	FOXP3	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]	Low confidence	219.889	208.064	1.05683
	TIAL1	nucleolysin tiar (tia-1 related protein). [swissprot;acc:q01085]	High confidence	227.202	192.823	1.17829
172	CAPZA1	f-actin capping protein alpha-1 subunit (capz alpha-1). [swissprot;acc:p52907]	Low confidence	213.671	202.205	1.0567
	TIPRL	cg9578-like; yeast ypr037w and worm c02c2.6 predicted proteins-like. [refseq;acc:nm_152902]	High confidence	174.667	205.556	1.17685
173	SNRPD1	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [swissprot;acc:p13641]		227.032	193.056	1.17599
	UNC84A	sad1/unc-84 protein-like 1. [swissprot;acc:o94901]	Low confidence	221.678	209.795	1.05664
174	DGCR14	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	High confidence	335	286	1.17133
	FOXP1	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	Low confidence	219.6	207.907	1.05624
175	COPS3	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]	High confidence	199.949	234.187	1.17123
	FOXP4	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	Low confidence	219.593	207.903	1.05623
176	POLE4	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]	High confidence	275.754	235.908	1.1689
	TNS3	tumor endothelial marker 6; thyroid specific ptb domain protein; tensin 3. [refseq;acc:nm_022748]	Low confidence	219.336	207.703	1.05601
177	NCBP2L	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	High confidence	229.406	196.695	1.1663
	POP7	ribonuclease p protein subunit p20 (ec 3.1.26.5) (rnasep protein p20) (hpop7). [swissprot;acc:o75817]	Low confidence	209.954	221.607	1.0555
178	no value	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	High confidence	226.887	194.72	1.1652
	BPNT1	3'(2'), 5'-bisphosphate nucleotidase 1; bisphosphate 3'-nucleotidase; bpntase; pap-inositol-1,4-phosphatase. [refseq;acc:nm_006085]	Low confidence	209.954	221.607	1.0555
179	no value	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	High confidence	226.884	194.79	1.16476

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.