MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Network Comparison Type	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 308 to 357 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	network_comparison	green
77	DGKD	diacylglycerol kinase, delta (ec 2.7.1.107) (diglyceride kinase) (dgk-delta) (dag kinase delta) (130 kda diacylglycerol kinase) (fragment). [swissprot;acc:q16760]	Subtracted	Low confidence	226.981	18.904	208.077
78	CACNG4	voltage-dependent calcium channel gamma-4 subunit (neuronal voltage- gated calcium channel gamma-4 subunit). [swissprot;acc:q9ubn1]		High confidence	254.691	52.023	202.668
	CACNG8	voltage-dependent calcium channel gamma-8 subunit (neuronal voltage- gated calcium channel gamma-8 subunit). [swissprot;acc:q8wxs5]	Divided		254.693	1.2567
	DFFB	dna fragmentation factor 40 kda subunit (ec 3.-.-.-) (dff-40) (caspase-activated deoxyribonuclease) (caspase-activated dnase) (cad) (caspase-activated nuclease) (cpan). [swissprot;acc:o76075]	Subtracted	Low confidence	233.922	18.613	215.309
	LENG4	malignant cell expression-enhanced gene/tumor progression-enhanc. [refseq;acc:nm_024298]	Divided		211	1.0978	231.635
79	APBA1	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]			229.144	1.09742	208.803
	CACNG3	voltage-dependent calcium channel gamma-3 subunit (neuronal voltage- gated calcium channel gamma-3 subunit). [swissprot;acc:o60359]		High confidence	254.693	1.2567	202.668
	CACNG5	voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02]	Subtracted		254.614	51.968	202.646
	DAB2IP	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]		Low confidence	247.334	18.494	228.84
80	no value	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]			226.338	18.464	207.874
	CACNG4	voltage-dependent calcium channel gamma-4 subunit (neuronal voltage- gated calcium channel gamma-4 subunit). [swissprot;acc:q9ubn1]	Divided	High confidence	254.691	1.25669	202.668
	RINT1	rad50-interacting protein 1. [refseq;acc:nm_021930]		Low confidence	221.194	1.09499	202.005
	SON	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	Subtracted	High confidence	294.053	51.491	242.562
81	CACNG5	voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02]	Divided		254.614	1.25645	202.646
	HOMER2	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]	Subtracted		252.371	50.355	202.016
	RASAL2	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]		Low confidence	247.087	18.394	228.693
	TFDP2	transcription factor dp-2 (e2f dimerization partner 2). [swissprot;acc:q14188]	Divided		227.623	1.09286	208.281
82	COQ7	ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807]	Subtracted	High confidence	252.329	50.325	202.004
	DGKH	diacylglycerol kinase, eta isoform 1. [refseq;acc:nm_152910]	Divided	Low confidence	226.981	1.09085	208.077
	GNB5	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]		High confidence	267.636	1.25304	335.359
	TAF2	tbp-associated factor 2; taf2 rna polymerase ii, tata box binding protein (tbp)-associated factor, 150 kd; tata box binding protein (tbp)-associated factor, rna polymerase ii, b, 150kd; cofactor of initiator function, 150kd subunit. [refseq;acc:nm_003184]	Subtracted	Low confidence	237.567	18.338	219.229
83	DGKD	diacylglycerol kinase, delta (ec 2.7.1.107) (diglyceride kinase) (dgk-delta) (dag kinase delta) (130 kda diacylglycerol kinase) (fragment). [swissprot;acc:q16760]	Divided		226.981	1.09085	208.077
	HOMER1	homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]	Subtracted	High confidence	252.309	50.311	201.998
	MAGED4	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	Divided		88.2482	1.24949	110.265
	STARD7	star-related lipid transfer protein 7 (stard7) (start domain- containing protein 7) (gtt1 protein). [swissprot;acc:q9nqz5]	Subtracted	Low confidence	228.743	17.979	210.764
84	no value	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]	Divided		226.338	1.08882	207.874
	HOMER3	homer, neuronal immediate early gene, 3. [refseq;acc:nm_004838]	Subtracted	High confidence	252.296	50.301	201.995
	MAGEE2	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	Divided		88.2482	1.24949	110.265
	OPHN1	oligophrenin 1. [swissprot;acc:o60890]	Subtracted	Low confidence	233.837	17.864	215.973
85	no value	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	Divided	High confidence	88.2482	1.24949	110.265
	ARHGAP26	oligophrenin-1 like protein (gtpase regulator associated with focal adhesion kinase). [swissprot;acc:q9una1]	Subtracted	Low confidence	233.592	17.746	215.846
	KCND2	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	Divided		225.735	1.08671	245.308
	UNC84A	sad1/unc-84 protein-like 1. [swissprot;acc:o94901]	Subtracted	High confidence	296.677	49.118	247.559
86	DFFB	dna fragmentation factor 40 kda subunit (ec 3.-.-.-) (dff-40) (caspase-activated deoxyribonuclease) (caspase-activated dnase) (cad) (caspase-activated nuclease) (cpan). [swissprot;acc:o76075]	Divided	Low confidence	233.922	1.08645	215.309
	DGCR14	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	Subtracted	High confidence	335	49	286
	MAGEA11	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	Divided		88.2482	1.24949	110.265
	ROGDI	leucine zipper domain protein. [refseq;acc:nm_024589]	Subtracted	Low confidence	221.996	16.824	238.82
87	DGKQ	diacylglycerol kinase, theta (ec 2.7.1.107) (diglyceride kinase) (dgk- theta) (dag kinase theta). [swissprot;acc:p52824]			229.556	16.1	213.456
	KCND3	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	Divided		225.545	1.08596	244.933
	MAGEA2B	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]		High confidence	88.2482	1.24949	110.265
	RBM15B	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	Subtracted		249.663	48.6	298.263
88	no value	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Divided		88.2482	1.24949	110.265
	CPD	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	Subtracted	Low confidence	16	16	32
	KCND1	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]	Divided		225.428	1.0855	244.701
	RGS19	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	Subtracted	High confidence	249.663	48.6	298.263
89	MAGEA6	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Divided		88.2482	1.24949	110.265
	RBM15	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	Subtracted		249.663	48.6	298.263
	STARD7	star-related lipid transfer protein 7 (stard7) (start domain- containing protein 7) (gtt1 protein). [swissprot;acc:q9nqz5]	Divided	Low confidence	228.743	1.0853	210.764
	UBR4	retinoblastoma-associated factor 600. [refseq;acc:nm_020765]	Subtracted		165.535	15.736	149.799
90	NDN	necdin. [swissprot;acc:q99608]	Divided	High confidence	88.2482	1.24949	110.265

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.