MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Network Comparison Type	Rank	description	Gene	Value Type	Hugo	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 3062 to 3111 of 16578 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Interaction Map	red	green	network_comparison
1531	cysteine-rich motor neuron 1; cysteine-rich repeat-containing protein s52 precursor. [refseq;acc:nm_016441]	CRIM1	High confidence	217.025	213.304	1.01744
1532	peptidylprolyl isomerase-like 4; cyclophilin-type peptidyl-prolyl cis-trans isomerase; ppiase; serologically defined breast cancer antigen ny-br-18. [refseq;acc:nm_139126]	PPIL4	Low confidence	203.549	199.307	1.02128
	rna-binding protein 10 (rna binding motif protein 10) (dxs8237e). [swissprot;acc:p98175]	RBM10	High confidence	228.419	232.376	1.01732
1533	cytochrome c. [swissprot;acc:p00001]	CYCS
	zinc-finger protein zpr1 (zinc finger protein 259). [swissprot;acc:o75312]	ZNF259	Low confidence	203.346	199.108	1.02128
1534	heparan sulfate 6-o-sulfotransferase 2. [refseq;acc:nm_147174]	HS6ST2	High confidence	228.419	232.376	1.01732
	mo25-like protein. [swissprot;acc:q9h9s4]	CAB39L	Low confidence	200.515	196.337	1.02128
1535	heparan sulfate 6-o-sulfotransferase; heparan-sulfate 6-sulfotransferase. [refseq;acc:nm_004807]	HS6ST1	High confidence	228.419	232.376	1.01732
	serine/threonine-protein kinase chk2 (ec 2.7.1.-) (cds1). [swissprot;acc:o96017]	CHEK2	Low confidence	200.266	196.095	1.02127
1536	cdp-diacylglycerol--inositol 3-phosphatidyltransferase (ec 2.7.8.11) (phosphatidylinositol synthase) (ptdins synthase) (pi synthase). [swissprot;acc:o14735]	CDIPT		198.934	194.79
	fatty acid hydroxylase domain containing 1. [refseq;acc:nm_024306]	FA2H	High confidence	228.419	232.376	1.01732
1537	dead-box protein 3, y-chromosomal. [swissprot;acc:o15523]	DDX3Y	Low confidence	200.879	196.696	1.02127
	ww domain binding protein 11; npw38-binding protein npwbp; sh3 domain-binding protein snp70. [refseq;acc:nm_016312]	WBP11	High confidence	228.419	232.376	1.01732
1538	elac homolog 2; putative prostate cancer susceptibility protein; elac (e. coli) homolog 2. [refseq;acc:nm_018127]	ELAC2
	mo25 protein (cgi-66). [swissprot;acc:q9y376]	CAB39	Low confidence	200.517	196.343	1.02126
1539	dead-box protein 3 (helicase-like protein 2) (hlp2) (dead-box, x isoform). [swissprot;acc:o00571]	no value		200.878	196.696
	rna-binding protein 5 (rna binding motif protein 5) (putative tumor suppressor luca15) (g15 protein). [swissprot;acc:p52756]	RBM5	High confidence	228.419	232.376	1.01732
1540	autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0]	ATG5		240.077	236.015	1.01721
	glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (ec 2.6.1.16) (hexosephosphate aminotransferase 2) (d-fructose-6- phosphate amidotransferase 2) (gfat 2) (gfat2). [swissprot;acc:o94808]	GFPT2	Low confidence	201.26	197.072	1.02125
1541	c-1-tetrahydrofolate synthase, cytoplasmic (c1-thf synthase) [includes: methylenetetrahydrofolate dehydrogenase (ec 1.5.1.5); methenyltetrahydrofolate cyclohydrolase (ec 3.5.4.9); formyltetrahydrofolate synthetase (ec 6.3.4.3)]. [swissprot;acc:p11586]	MTHFD1		203.321	199.093	1.02124
	myb proto-oncogene protein (c-myb). [swissprot;acc:p10242]	MYB	High confidence	222.672	218.92	1.01714
1542	trimethyllysine dioxygenase, mitochondrial precursor (ec 1.14.11.8) (epsilon-trimethyllysine 2-oxoglutarate dioxygenase) (tml-alpha- ketoglutarate dioxygenase) (tml hydroxylase) (tml dioxygenase) (tmld). [swissprot;acc:q9nvh6]	TMLHE		213.546	209.965	1.01706
	vav-2 protein. [swissprot;acc:p52735]	VAV2	Low confidence	200.389	196.224	1.02123
1543	gtp-binding protein era homolog (hera) (fragment). [swissprot;acc:o75616]	ERAL1	High confidence	213.546	209.965	1.01706
	homeobox protein hox-b6 (hox-2b) (hox-2.2) (hu-2). [swissprot;acc:p17509]	HOXB6	Low confidence	203.129	198.906	1.02123
1544	orphan nuclear receptor nr2e1 (nuclear receptor tlx) (tailless homolog) (tll) (htll). [swissprot;acc:q9y466]	NR2E1	High confidence	219.762	216.081	1.01704
	park2 co-regulated; parkin co-regulated gene protein. [refseq;acc:nm_152410]	PACRG	Low confidence	203.124	198.907	1.0212
1545	orphan nuclear receptor tr2. [swissprot;acc:p13056]	NR2C1	High confidence	219.76	216.083	1.01702
	vacuolar atp synthase subunit h (ec 3.6.3.14) (v-atpase h subunit) (vacuolar proton pump h subunit) (v-atpase 50/57 kda subunits) (vacuolar proton pump subunit sfd) (cgi-11). [swissprot;acc:q9ui12]	ATP6V1H	Low confidence	199.511	195.372	1.02119
1546	argininosuccinate synthase (ec 6.3.4.5) (citrulline--aspartate ligase). [swissprot;acc:p00966]	ASS1	High confidence	217.769	221.474	1.01701
	glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (ec 2.6.1.16) (hexosephosphate aminotransferase 1) (d-fructose-6- phosphate amidotransferase 1) (gfat 1) (gfat1). [swissprot;acc:q06210]	no value	Low confidence	201.261	197.087	1.02118
1547	myb-related protein b (b-myb). [swissprot;acc:p10244]	MYBL2	High confidence	222.541	218.823	1.01699
	vacuolar atp synthase subunit g 1 (ec 3.6.3.14) (v-atpase g subunit 1) (vacuolar proton pump g subunit 1) (v-atpase 13 kda subunit 1) (vacuolar atp synthase subunit m16). [swissprot;acc:o75348]	ATP6V1G1	Low confidence	202.348	198.152	1.02118
1548	myb-related protein a (a-myb). [swissprot;acc:p10243]	MYBL1	High confidence	222.512	218.802	1.01696
	ubiquitin conjugation factor e4 b (ubiquitin-fusion degradation protein 2) (homozygously deleted in neuroblastoma-1). [swissprot;acc:o95155]	UBE4B	Low confidence	202.493	198.294	1.02118
1549	beta adducin (erythrocyte adducin beta subunit). [swissprot;acc:p35612]	ADD2		205.847	201.577
	dynactin complex 50 kda subunit (50 kda dynein-associated polypeptide) (dynamitin) (dctn-50) (dynactin 2). [swissprot;acc:q13561]	DCTN2	High confidence	225.159	221.424	1.01687
1550	adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236]	SLC25A6
	ras-related protein rab-6c (rab6-like protein wth3). [swissprot;acc:q9h0n0]	no value	Low confidence	200.571	196.413	1.02117
1551	adp,atp carrier protein, heart/skeletal muscle isoform t1 (adp/atp translocase 1) (adenine nucleotide translocator 1) (ant 1). [swissprot;acc:p12235]	SLC25A4	High confidence	225.159	221.424	1.01687
	thyroid receptor interacting protein 3 (trip-3) (fragment). [swissprot;acc:q15649]	ZNHIT3	Low confidence	201.491	197.313	1.02117
1552	adp,atp carrier protein, fibroblast isoform (adp/atp translocase 2) (adenine nucleotide translocator 2) (ant 2). [swissprot;acc:p05141]	SLC25A5	High confidence	225.159	221.424	1.01687
	homeobox protein hox-a6 (hox-1b). [swissprot;acc:p31267]	HOXA6	Low confidence	203.119	198.908	1.02117
1553	adenosylhomocysteinase (ec 3.3.1.1) (s-adenosyl-l-homocysteine hydrolase) (adohcyase). [swissprot;acc:p23526]	AHCY	High confidence	215.389	211.833	1.01679
	adrenoleukodystrophy protein (aldp). [swissprot;acc:p33897]	ABCD1	Low confidence	202.418	206.704	1.02117
1554	c-terminal binding protein 1 (ctbp1). [swissprot;acc:q13363]	CTBP1	High confidence	196.215	193.018	1.01656
	ras-related protein rab-6b. [swissprot;acc:q9nrw1]	RAB6B	Low confidence	200.567	196.41	1.02116
1555	pas domain containing serine/threonine kinase; pas-serine/threonine kinase. [refseq;acc:nm_015148]	PASK	High confidence	196.192	192.996	1.01656
	vacuolar atp synthase subunit g 3 (ec 3.6.3.14) (v-atpase g subunit 3) (vacuolar proton pump g subunit 3) (v-atpase 13 kda subunit 3). [swissprot;acc:q96lb4]	ATP6V1G3	Low confidence	202.345	198.152	1.02116
1556	b-cell lymphoma 6 protein (bcl-6) (zinc finger protein 51) (laz-3 protein) (bcl-5). [swissprot;acc:p41182]	BCL6	High confidence	196.192	192.996	1.01656

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.