MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 3058 to 3107 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
1529	MYB	myb proto-oncogene protein (c-myb). [swissprot;acc:p10242]	Subtracted	222.672	218.92	3.752
1530	CDC25B	m-phase inducer phosphatase 2 (ec 3.1.3.48) (dual specificity phosphatase cdc25b). [swissprot;acc:p30305]		260.269	256.531	3.738
	MLLT4	af-6 protein. [swissprot;acc:p55196]	Divided	218.733	214.98	1.01746
1531	CRIM1	cysteine-rich motor neuron 1; cysteine-rich repeat-containing protein s52 precursor. [refseq;acc:nm_016441]		217.025	213.304	1.01744
	DCTN2	dynactin complex 50 kda subunit (50 kda dynein-associated polypeptide) (dynamitin) (dctn-50) (dynactin 2). [swissprot;acc:q13561]	Subtracted	225.159	221.424	3.735
1532	RBM10	rna-binding protein 10 (rna binding motif protein 10) (dxs8237e). [swissprot;acc:p98175]	Divided	228.419	232.376	1.01732
	SLC25A6	adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236]	Subtracted	225.159	221.424	3.735
1533	CYCS	cytochrome c. [swissprot;acc:p00001]	Divided	228.419	232.376	1.01732
	SLC25A4	adp,atp carrier protein, heart/skeletal muscle isoform t1 (adp/atp translocase 1) (adenine nucleotide translocator 1) (ant 1). [swissprot;acc:p12235]	Subtracted	225.159	221.424	3.735
1534	BCKDK	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor (ec 2.7.1.115) (branched-chain alpha-ketoacid dehydrogenase kinase) (bckdhkin) (bckd-kinase). [swissprot;acc:o14874]		213.259	209.524
	HS6ST2	heparan sulfate 6-o-sulfotransferase 2. [refseq;acc:nm_147174]	Divided	228.419	232.376	1.01732
1535	HS6ST1	heparan sulfate 6-o-sulfotransferase; heparan-sulfate 6-sulfotransferase. [refseq;acc:nm_004807]
	SLC25A5	adp,atp carrier protein, fibroblast isoform (adp/atp translocase 2) (adenine nucleotide translocator 2) (ant 2). [swissprot;acc:p05141]	Subtracted	225.159	221.424	3.735
1536	ACTG1	actin, cytoplasmic 2 (gamma-actin). [swissprot;acc:p02571]		216.762	213.031	3.731
	FA2H	fatty acid hydroxylase domain containing 1. [refseq;acc:nm_024306]	Divided	228.419	232.376	1.01732
1537	CRIM1	cysteine-rich motor neuron 1; cysteine-rich repeat-containing protein s52 precursor. [refseq;acc:nm_016441]	Subtracted	217.025	213.304	3.721
	WBP11	ww domain binding protein 11; npw38-binding protein npwbp; sh3 domain-binding protein snp70. [refseq;acc:nm_016312]	Divided	228.419	232.376	1.01732
1538	ELAC2	elac homolog 2; putative prostate cancer susceptibility protein; elac (e. coli) homolog 2. [refseq;acc:nm_018127]
	MYBL2	myb-related protein b (b-myb). [swissprot;acc:p10244]	Subtracted	222.541	218.823	3.718
1539	MYBL1	myb-related protein a (a-myb). [swissprot;acc:p10243]		222.512	218.802	3.71
	RBM5	rna-binding protein 5 (rna binding motif protein 5) (putative tumor suppressor luca15) (g15 protein). [swissprot;acc:p52756]	Divided	228.419	232.376	1.01732
1540	ASS1	argininosuccinate synthase (ec 6.3.4.5) (citrulline--aspartate ligase). [swissprot;acc:p00966]	Subtracted	217.769	221.474	3.705
	ATG5	autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0]	Divided	240.077	236.015	1.01721
1541	CSE1L	importin-alpha re-exporter (chromosome segregation 1-like protein) (cellular apoptosis susceptibility protein). [swissprot;acc:p55060]	Subtracted	192.336	188.637	3.699
	MYB	myb proto-oncogene protein (c-myb). [swissprot;acc:p10242]	Divided	222.672	218.92	1.01714
1542	NR2E1	orphan nuclear receptor nr2e1 (nuclear receptor tlx) (tailless homolog) (tll) (htll). [swissprot;acc:q9y466]	Subtracted	219.762	216.081	3.681
	TMLHE	trimethyllysine dioxygenase, mitochondrial precursor (ec 1.14.11.8) (epsilon-trimethyllysine 2-oxoglutarate dioxygenase) (tml-alpha- ketoglutarate dioxygenase) (tml hydroxylase) (tml dioxygenase) (tmld). [swissprot;acc:q9nvh6]	Divided	213.546	209.965	1.01706
1543	ERAL1	gtp-binding protein era homolog (hera) (fragment). [swissprot;acc:o75616]
	NR2C1	orphan nuclear receptor tr2. [swissprot;acc:p13056]	Subtracted	219.76	216.083	3.677
1544	NR2E1	orphan nuclear receptor nr2e1 (nuclear receptor tlx) (tailless homolog) (tll) (htll). [swissprot;acc:q9y466]	Divided	219.762	216.081	1.01704
	TYMS	thymidylate synthase (ec 2.1.1.45) (ts) (tsase). [swissprot;acc:p04818]	Subtracted	225.119	228.769	3.65
1545	no value	dihydrofolate reductase (ec 1.5.1.3). [swissprot;acc:p00374]
	NR2C1	orphan nuclear receptor tr2. [swissprot;acc:p13056]	Divided	219.76	216.083	1.01702
1546	ASS1	argininosuccinate synthase (ec 6.3.4.5) (citrulline--aspartate ligase). [swissprot;acc:p00966]		217.769	221.474	1.01701
	SDF2	stromal cell-derived factor 2 precursor (sdf-2). [swissprot;acc:q99470]	Subtracted	225.119	228.769	3.65
1547	MYBL2	myb-related protein b (b-myb). [swissprot;acc:p10244]	Divided	222.541	218.823	1.01699
	SDF2L1	stromal cell-derived factor 2-like protein 1 precursor (sdf2 like protein 1) (pwp1-interacting protein 8). [swissprot;acc:q9hcn8]	Subtracted	225.119	228.769	3.65
1548	EIF3K	eukaryotic translation initiation factor 3 subunit 11 (eif-3 p25) (eif3k) (muscle specific gene m9 protein) (ptd001) (hspc029) (arg134). [swissprot;acc:q9ubq5]		221.128	224.767	3.639
	MYBL1	myb-related protein a (a-myb). [swissprot;acc:p10243]	Divided	222.512	218.802	1.01696
1549	DCTN2	dynactin complex 50 kda subunit (50 kda dynein-associated polypeptide) (dynamitin) (dctn-50) (dynactin 2). [swissprot;acc:q13561]		225.159	221.424	1.01687
	SLMO1	erythroid differentiation and denucleation factor 1. [swissprot;acc:o60584]	Subtracted	221.128	224.767	3.639
1550	BBS7	bardet-biedl syndrome 7 protein isoform a; bbs2-like 1. [refseq;acc:nm_176824]
	SLC25A6	adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236]	Divided	225.159	221.424	1.01687
1551	no value	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	Subtracted	221.128	224.767	3.639
	SLC25A4	adp,atp carrier protein, heart/skeletal muscle isoform t1 (adp/atp translocase 1) (adenine nucleotide translocator 1) (ant 1). [swissprot;acc:p12235]	Divided	225.159	221.424	1.01687
1552	no value	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	Subtracted	221.128	224.767	3.639
	SLC25A5	adp,atp carrier protein, fibroblast isoform (adp/atp translocase 2) (adenine nucleotide translocator 2) (ant 2). [swissprot;acc:p05141]	Divided	225.159	221.424	1.01687
1553	AHCY	adenosylhomocysteinase (ec 3.3.1.1) (s-adenosyl-l-homocysteine hydrolase) (adohcyase). [swissprot;acc:p23526]		215.389	211.833	1.01679
	SLMO2	protein c20orf45 (cgi-107). [swissprot;acc:q9y3b1]	Subtracted	221.128	224.767	3.639
1554	CTBP1	c-terminal binding protein 1 (ctbp1). [swissprot;acc:q13363]	Divided	196.215	193.018	1.01656

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.