MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Rank	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 3012 to 3061 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	Value Type	red	green	network_comparison
ba305p22.3 (breast carcinoma amplified sequence 4). [sptrembl;acc:q8ndy6]	907	BHLHB4	Divided	Measured	11852.9	10773.5	1.10019
	931			Ranked	159.13	164.917	1.03637
	952		Subtracted	Rooted	93.3148	89.7311	3.5837
	1110			Ranked	159.13	164.917	5.787
	1389		Divided	Rooted	93.3148	89.7311	1.03994
ba395l14.12 (novel protein similar to small nuclear ribonucleoprotein polypeptide a' (snrpa1)). [sptrembl;acc:q9nu36]	280	no value			57.9068	64.8562	1.12001
	299			Measured	4914.27	5907.12	1.20203
	344		Subtracted	Rooted	57.9068	64.8562	6.9494
	355			Measured	4914.27	5907.12	992.85
	452		Divided	Ranked	224.161	207.972	1.07784
	455		Subtracted				16.189
	751		Divided	Squared	20305.9	23689.4	1.16663
	1036		Subtracted				3383.5
ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	1551			Ranked	221.128	224.767	3.639
	1568		Divided				1.01646
	1929		Subtracted	Squared	22746.3	24873.5	2127.2
	1937		Divided				1.09352
	2130			Measured	5328.73	5616.59	1.05402
	2177		Subtracted				287.86
	2465		Divided	Rooted	59.9326	60.6973	1.01276
	2479		Subtracted				0.7647
ba528a10.3.2 (novel protein similar to kiaa0161, isoform 2) (fragment). [sptrembl;acc:q9bx39]	2968	RNF144B	Divided	Measured	0.00001	0.00001	1
				Ranked
				Squared
				Rooted
			Subtracted	Measured	0	0	0
				Ranked
				Squared
				Rooted
bactericidal permeability-increasing protein precursor (bpi) (cap 57). [swissprot;acc:p17213]	717	BPI		Ranked	224.434	235.583	11.149
	757		Divided				1.04968
	1174			Squared	20923.6	23813.2	1.1381
	1319		Subtracted				2889.6
	2328			Measured	5123.89	5350.78	226.89
	2338		Divided				1.04428
	2410			Rooted	58.7808	57.9198	1.01487
	2435		Subtracted				0.861
baculoviral iap repeat-containing protein 5 (apoptosis inhibitor survivin) (apoptosis inhibitor 4). [swissprot;acc:o15392]	1958	BIRC5		Measured	5976.81	6323.87	347.06
	1983			Squared	29169.3	31251.6	2082.3
	2024		Divided	Measured	5976.81	6323.87	1.05807
	2099			Rooted	62.2973	63.8665	1.02519
	2103		Subtracted				1.5692
	2359		Divided	Squared	29169.3	31251.6	1.07139
	2487		Subtracted	Ranked	218.949	219.552	0.603
	2500		Divided				1.00275
bag-family molecular chaperone regulator-1 (bcl-2 binding athanogene- 1) (bag-1) (glucocorticoid receptor-associated protein rap46). [swissprot;acc:q99933]	1075	BAG1	Subtracted	Squared	31163.9	34454.3	3290.4
	1088			Measured	6439.79	6959.21	519.42
	1322		Divided				1.08066
	1391		Subtracted	Rooted	65.2132	67.7352	2.522
	1464		Divided				1.03867

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.