MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 3012 to 3061 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1
red  : 0.00001
green  : 0.00001
network_comparison  : 1

Rank	description	Hugo
3012	small nuclear ribonucleoprotein associated proteins b and b' (snrnp-b) (sm protein b/b') (sm-b/sm-b') (smb/smb'). [swissprot;acc:p14678]	SNRPB
3013	major centromere autoantigen b (centromere protein b) (cenp-b). [swissprot;acc:p07199]	CENPB
3014	mitochondrial deoxynucleotide carrier (mitochondrial uncoupling protein 1). [swissprot;acc:q9hc21]	SLC25A19
3015	pericentrin 1; frount; nucleoporin nup75. [refseq;acc:nm_024844]	NUP85
3016	mitochondrial ribosomal protein s7; 30s ribosomal protein s7 homolog. [refseq;acc:nm_015971]	MRPS7
3017	leucine rich repeat (in flii) interacting protein 1. [refseq;acc:nm_004735]	LRRFIP1
3018	cysteine-rich secretory protein-1 precursor (crisp-1) (acidic epididymal glycoprotein homolog) (aeg-like protein) (arp). [swissprot;acc:p54107]	CRISP1
3019	testis intracellular mediator protein. [refseq;acc:nm_057161]	KLHDC3
3020	protein kinase c and casein kinase substrate in neurons protein 1. [swissprot;acc:q9by11]	PACSIN1
3021	testis-specific protein tpx-1 precursor (cysteine-rich secretory protein-2) (crisp-2). [swissprot;acc:p16562]	CRISP2
3022	n-acetylglucosamine kinase (ec 2.7.1.59) (glcnac kinase). [swissprot;acc:q9uj70]	NAGK
3023	vesicle-associated membrane protein-associated protein b/c (vamp- associated protein b/c) (vamp-b/vamp-c) (vap-b/vap-c). [swissprot;acc:o95292]	VAPB
3024	phosphatidylinositol glycan class t precursor. [refseq;acc:nm_015937]	PIGT
3025	dj579f20.1 (high-mobility group (nonhistone chromosomal) protein 1-like 1). [sptrembl;acc:q9nqj4]	HMG1L1
3026	solute carrier family 36 member 1; proton / amino acid symporter; lysosomal amino acid transporter 1. [refseq;acc:nm_078483]	SLC36A1
3027	elongation factor ts, mitochondrial precursor (ef-ts) (ef-tsmt). [swissprot;acc:p43897]	TSFM
3028	clll6 protein. [refseq;acc:nm_020456]	C13orf1
3029	dynein intermediate chain 1, axonemal (axonemal dynein intermediate chain 1). [swissprot;acc:q9ui46]	DNAI1
3030	uncharacterized bone marrow protein bm033. [refseq;acc:nm_018452]	C6orf35
3031	speckle-type poz protein. [swissprot;acc:o43791]	SPOP
3032	similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]	LYZL1
3033	glycerol-3-phosphate acyltransferase, mitochondrial precursor (ec 2.3.1.15) (gpat). [swissprot;acc:q9hcl2]	GPAM
3034	postsynaptic protein cript; hspc139 protein. [refseq;acc:nm_014171]	CRIPT
3035	transforming growth factor beta 3 precursor (tgf-beta 3). [swissprot;acc:p10600]	TGFB3
3036	placenta growth factor precursor (plgf). [swissprot;acc:p49763]	PGF
3037	skd1 protein (vacuolar sorting protein 4b). [swissprot;acc:o75351]	VPS4B
3038	spectrin alpha chain, brain (spectrin, non-erythroid alpha chain) (alpha-ii spectrin) (fodrin alpha chain). [swissprot;acc:q13813]	no value
3039	set protein (hla-dr associated protein ii) (phapii) (phosphatase 2a inhibitor i2pp2a). [swissprot;acc:q01105]	SET
3040	connective tissue growth factor precursor (hypertrophic chondrocyte- specific protein 24). [swissprot;acc:p29279]	CTGF
3041	transthyretin precursor (prealbumin) (tbpa) (ttr) (attr). [swissprot;acc:p02766]	TTR
3042	orphan nuclear receptor nr5a2 (alpha-1-fetoprotein transcription factor) (hepatocytic transcription factor) (b1-binding factor) (hb1f) (cyp7a promoter binding factor). [swissprot;acc:o00482]	NR5A2
3043	transcription termination factor, rna polymerase ii; lodestar protein. [refseq;acc:nm_003594]	TTF2
3044	late endosomal/lysosomal mp1 interacting protein (p14) (hspc003). [swissprot;acc:q9y2q5]	no value
3045	dna mismatch repair protein msh6 (muts-alpha 160 kda subunit) (g/t mismatch binding protein) (gtbp) (gtmbp) (p160). [swissprot;acc:p52701]	MSH6
3046	langerhans cell specific c-type lectin. [refseq;acc:nm_015717]	CD207
3047	origin recognition complex subunit 2. [swissprot;acc:q13416]	ORC2L
3048	serine/threonine protein kinase 25 (ec 2.7.1.37) (sterile 20/oxidant stress-response kinase 1) (ste20/oxidant stress response kinase-1) (sok-1) (ste20-like kinase). [swissprot;acc:o00506]	STK25
3049	zinc transporter 3 (znt-3). [swissprot;acc:q99726]	SLC30A3
3050	activin receptor type i precursor (ec 2.7.1.37) (actr-i) (serine/threonine-protein kinase receptor r1) (skr1) (activin receptor-like kinase 2) (alk-2) (tgf-b superfamily receptor type i) (tsr-i). [swissprot;acc:q04771]	ACVR1
3051	putative tumor suppressor 101f6. [refseq;acc:nm_007022]	CYB561D2
3052	programmed cell death 10; apoptosis-related protein 15. [refseq;acc:nm_007217]	PDCD10
3053	homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [swissprot;acc:q93099]	HGD
3054	double-stranded rna-binding zinc finger protein jaz. [refseq;acc:nm_012279]	ZNF346
3055	vacuolar atp synthase subunit h (ec 3.6.3.14) (v-atpase h subunit) (vacuolar proton pump h subunit) (v-atpase m9.2 subunit) (v-atpase 9.2 kda membrane accessory protein). [swissprot;acc:o15342]	ATP6V0E1
3056	protein transport protein sec24a (sec24-related protein a) (fragment). [swissprot;acc:o95486]	SEC24A
3057	complement component c9 precursor. [swissprot;acc:p02748]	C9
3058	glucosamine-6-phosphate isomerase (ec 3.5.99.6) (glucosamine-6- phosphate deaminase) (gnpda) (glcn6p deaminase) (oscillin). [swissprot;acc:p46926]	GNPDA1
3059	ribonuclease iii (ec 3.1.26.3) (rnase iii) (p241). [swissprot;acc:q9nrr4]	RNASEN
3060	tetratricopeptide repeat protein 1 (tpr repeat protein 1). [swissprot;acc:q99614]	TTC1
3061	kiaa1194. [refseq;acc:nm_015455]	CNOT6

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.