MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 301 to 350 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	green	network_comparison
76	CACNG3	voltage-dependent calcium channel gamma-3 subunit (neuronal voltage- gated calcium channel gamma-3 subunit). [swissprot;acc:o60359]	Subtracted	High confidence	254.693	202.668	52.025
	DGKH	diacylglycerol kinase, eta isoform 1. [refseq;acc:nm_152910]		Low confidence	226.981	208.077	18.904
	NIPSNAP1	nipsnap1 protein. [swissprot;acc:q9bpw8]	Divided		249.584	226.86	1.10017
	TMEM33	db83 protein. [swissprot;acc:p57088]		High confidence	288	362	1.25694
77	no value	putative adenosylhomocysteinase 3 (ec 3.3.1.1) (s-adenosyl-l- homocysteine hydrolase) (adohcyase). [swissprot;acc:q96hn2]		Low confidence	195.851	215.424	1.09994
	CACNG2	voltage-dependent calcium channel gamma-2 subunit (neuronal voltage- gated calcium channel gamma-2 subunit). [swissprot;acc:q9y698]		High confidence	254.692	202.668	1.2567
			Subtracted				52.024
	DGKD	diacylglycerol kinase, delta (ec 2.7.1.107) (diglyceride kinase) (dgk-delta) (dag kinase delta) (130 kda diacylglycerol kinase) (fragment). [swissprot;acc:q16760]		Low confidence	226.981	208.077	18.904
78	CACNG4	voltage-dependent calcium channel gamma-4 subunit (neuronal voltage- gated calcium channel gamma-4 subunit). [swissprot;acc:q9ubn1]		High confidence	254.691	202.668	52.023
	CACNG8	voltage-dependent calcium channel gamma-8 subunit (neuronal voltage- gated calcium channel gamma-8 subunit). [swissprot;acc:q8wxs5]	Divided		254.693		1.2567
	DFFB	dna fragmentation factor 40 kda subunit (ec 3.-.-.-) (dff-40) (caspase-activated deoxyribonuclease) (caspase-activated dnase) (cad) (caspase-activated nuclease) (cpan). [swissprot;acc:o76075]	Subtracted	Low confidence	233.922	215.309	18.613
	LENG4	malignant cell expression-enhanced gene/tumor progression-enhanc. [refseq;acc:nm_024298]	Divided		211	231.635	1.0978
79	APBA1	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]			229.144	208.803	1.09742
	CACNG3	voltage-dependent calcium channel gamma-3 subunit (neuronal voltage- gated calcium channel gamma-3 subunit). [swissprot;acc:o60359]		High confidence	254.693	202.668	1.2567
	CACNG5	voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02]	Subtracted		254.614	202.646	51.968
	DAB2IP	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]		Low confidence	247.334	228.84	18.494
80	no value	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]			226.338	207.874	18.464
	CACNG4	voltage-dependent calcium channel gamma-4 subunit (neuronal voltage- gated calcium channel gamma-4 subunit). [swissprot;acc:q9ubn1]	Divided	High confidence	254.691	202.668	1.25669
	RINT1	rad50-interacting protein 1. [refseq;acc:nm_021930]		Low confidence	221.194	202.005	1.09499
	SON	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	Subtracted	High confidence	294.053	242.562	51.491
81	CACNG5	voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02]	Divided		254.614	202.646	1.25645
	HOMER2	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]	Subtracted		252.371	202.016	50.355
	RASAL2	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]		Low confidence	247.087	228.693	18.394
	TFDP2	transcription factor dp-2 (e2f dimerization partner 2). [swissprot;acc:q14188]	Divided		227.623	208.281	1.09286
82	COQ7	ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807]	Subtracted	High confidence	252.329	202.004	50.325
	DGKH	diacylglycerol kinase, eta isoform 1. [refseq;acc:nm_152910]	Divided	Low confidence	226.981	208.077	1.09085
	GNB5	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]		High confidence	267.636	335.359	1.25304
	TAF2	tbp-associated factor 2; taf2 rna polymerase ii, tata box binding protein (tbp)-associated factor, 150 kd; tata box binding protein (tbp)-associated factor, rna polymerase ii, b, 150kd; cofactor of initiator function, 150kd subunit. [refseq;acc:nm_003184]	Subtracted	Low confidence	237.567	219.229	18.338
83	DGKD	diacylglycerol kinase, delta (ec 2.7.1.107) (diglyceride kinase) (dgk-delta) (dag kinase delta) (130 kda diacylglycerol kinase) (fragment). [swissprot;acc:q16760]	Divided		226.981	208.077	1.09085
	HOMER1	homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]	Subtracted	High confidence	252.309	201.998	50.311
	MAGED4	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	Divided		88.2482	110.265	1.24949
	STARD7	star-related lipid transfer protein 7 (stard7) (start domain- containing protein 7) (gtt1 protein). [swissprot;acc:q9nqz5]	Subtracted	Low confidence	228.743	210.764	17.979
84	no value	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]	Divided		226.338	207.874	1.08882
	HOMER3	homer, neuronal immediate early gene, 3. [refseq;acc:nm_004838]	Subtracted	High confidence	252.296	201.995	50.301
	MAGEE2	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	Divided		88.2482	110.265	1.24949
	OPHN1	oligophrenin 1. [swissprot;acc:o60890]	Subtracted	Low confidence	233.837	215.973	17.864
85	no value	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	Divided	High confidence	88.2482	110.265	1.24949
	ARHGAP26	oligophrenin-1 like protein (gtpase regulator associated with focal adhesion kinase). [swissprot;acc:q9una1]	Subtracted	Low confidence	233.592	215.846	17.746
	KCND2	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	Divided		225.735	245.308	1.08671
	UNC84A	sad1/unc-84 protein-like 1. [swissprot;acc:o94901]	Subtracted	High confidence	296.677	247.559	49.118
86	DFFB	dna fragmentation factor 40 kda subunit (ec 3.-.-.-) (dff-40) (caspase-activated deoxyribonuclease) (caspase-activated dnase) (cad) (caspase-activated nuclease) (cpan). [swissprot;acc:o76075]	Divided	Low confidence	233.922	215.309	1.08645
	DGCR14	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	Subtracted	High confidence	335	286	49
	MAGEA11	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	Divided		88.2482	110.265	1.24949
	ROGDI	leucine zipper domain protein. [refseq;acc:nm_024589]	Subtracted	Low confidence	221.996	238.82	16.824
87	DGKQ	diacylglycerol kinase, theta (ec 2.7.1.107) (diglyceride kinase) (dgk- theta) (dag kinase theta). [swissprot;acc:p52824]			229.556	213.456	16.1
	KCND3	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	Divided		225.545	244.933	1.08596
	MAGEA2B	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]		High confidence	88.2482	110.265	1.24949
	RBM15B	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	Subtracted		249.663	298.263	48.6
88	no value	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Divided		88.2482	110.265	1.24949
	CPD	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	Subtracted	Low confidence	16	32	16

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.