MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2962 to 3011 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	red	green	network_comparison
kh-type splicing regulatory protein (fuse binding protein 2); kh-type splicing regulatory protein (fuse-binding protein 2). [refseq;acc:nm_003685]	2650	KHSRP	Divided	217.188	216.942	1.00113
kiaa1194. [refseq;acc:nm_015455]	3061	CNOT6		0.00001	0.00001	1
			Subtracted	0	0	0
kidney and liver proline oxidase 1. [refseq;acc:nm_021232]	1997	PRODH2	Divided	204.651	202.759	1.00933
	2010		Subtracted			1.892
kinesin family member c3. [refseq;acc:nm_005550]	1496	KIFC3		214.727	210.838	3.889
	1501		Divided			1.01845
kinesin heavy chain (ubiquitous kinesin heavy chain) (ukhc). [swissprot;acc:p33176]	2479	KIF5B	Subtracted	218.093	218.72	0.627
	2482		Divided			1.00287
kinesin heavy chain isoform 5c (kinesin heavy chain neuron-specific 2). [swissprot;acc:o60282]	2480	KIF5C	Subtracted			0.627
	2483		Divided			1.00287
kinesin light chain 1 (klc 1). [swissprot;acc:q07866]	2482	KLC1	Subtracted			0.627
	2485		Divided			1.00287
kinesin light chain 2 (klc 2). [swissprot;acc:q9h0b6]	2478	KLC2	Subtracted			0.627
	2481		Divided			1.00287
kinesin protein. [refseq;acc:nm_032559]	1143	KIF2B	Subtracted	224.858	219.264	5.594
	1196		Divided			1.02551
kinesin-like protein kif13a (kinesin-like protein rbkin). [swissprot;acc:q9h1h9]	1175	KIF13A	Subtracted	214.364	219.759	5.395
	1212		Divided			1.02517
kinesin-like protein kif13b (kinesin-like protein gakin). [swissprot;acc:q9nqt8]	1177	no value	Subtracted			5.395
	1214		Divided			1.02517
kinesin-like protein kif2 (kinesin-2) (hk2). [swissprot;acc:o00139]	1149	KIF2A	Subtracted	224.764	219.241	5.523
	1210		Divided			1.02519
kinesin-like protein kif23 (mitotic kinesin-like protein-1) (kinesin- like protein 5). [swissprot;acc:q02241]	2557	KIF23	Subtracted	219.907	220.267	0.36
	2567		Divided			1.00164
kinesin-like protein kif3b (microtubule plus end-directed kinesin motor 3b) (hh0048). [swissprot;acc:o15066]	2224	KIF3B	Subtracted	219.047	220.371	1.324
	2253		Divided			1.00604
kinesin-like protein kif3c. [swissprot;acc:o14782]	2223	KIF3C	Subtracted	219.045	220.377	1.332
	2248		Divided			1.00608
kininogen precursor (alpha-2-thiol proteinase inhibitor) [contains: bradykinin]. [swissprot;acc:p01042]	706	KNG1	Subtracted	220.438	209.118	11.32
	707		Divided			1.05413
krueppel-like factor 5 (intestinal-enriched krueppel-like factor) (colon krueppel-like factor) (transcription factor bteb2) (basic transcription element binding protein 2) (bte-binding protein 2) (gc box binding protein 2). [swissprot;acc:q13887]	461	KLF5		223.648	207.62	1.0772
	464		Subtracted			16.028
kruppel-related zinc finger protein hckrox. [refseq;acc:nm_015872]	2445	ZBTB7B	Divided	206.088	206.756	1.00324
	2457		Subtracted			0.668
kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	71	KCNIP1		265.686	319.651	53.965
	144		Divided			1.20312
kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]	73	KCNIP2	Subtracted	265.632	319.531	53.899
	146		Divided			1.20291
kynureninase (ec 3.7.1.3) (l-kynurenine hydrolase). [swissprot;acc:q16719]	1475	KYNU		181.882	178.438	1.0193
	1588		Subtracted			3.444
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase). [refseq;acc:nm_003679]	2198	KMO	Divided	193.787	195.064	1.00659
	2240		Subtracted			1.277
l-myc-1 proto-oncogene protein. [swissprot;acc:p12524]	847	MYCL1		227.604	219.001	8.603
	881		Divided			1.03928
lactamase, beta 2. [refseq;acc:nm_016027]	2914	LACTB2		0.00001	0.00001	1
			Subtracted	0	0	0
lactoylglutathione lyase (ec 4.4.1.5) (methylglyoxalase) (aldoketomutase) (glyoxalase i) (glx i) (ketone-aldehyde mutase) (s-d-lactoylglutathione methylglyoxal lyase). [swissprot;acc:q04760]	2409	GLO1	Divided	194.407	193.706	1.00362
	2440		Subtracted			0.701
lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	214	LASS2	Divided	191.644	170.192	1.12605

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.