MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 2958 to 3007 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Interaction Map	red	green	network_comparison
gpp34-related protein. [refseq;acc:nm_018178]	4583	GOLPH3L	Low confidence	198.271	199.756	1.00749
grancalcin. [swissprot;acc:p28676]	796	GCA		202.524	197.308	1.02644
	942		High confidence	212.442	205.088	1.03586
grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [swissprot;acc:o75791]	551	GRAP2		207.261	194.347	1.06645
	1308		Low confidence	199.268	194.914	1.02234
grb2-related adaptor protein. [swissprot;acc:q13588]	441	GRAP	High confidence	223.457	207.222	1.07835
	552		Low confidence	203.511	197.267	1.03165
grip1 protein (fragment). [sptrembl;acc:q9y3r0]	3595	GRIP1		201.924	199.055	1.01441
group iii secretory phospholipase a2 precursor (ec 3.1.1.4) (phosphatidylcholine 2-acylhydrolase giii) (giii spla2). [swissprot;acc:q9nz20]	1679	PLA2G3		200.947	196.885	1.02063
growth arrest and dna-damage-inducible protein gadd45 alpha (dna- damage inducible transcript 1) (ddit1). [swissprot;acc:p24522]	1114	GADD45A	High confidence	251.863	258.829	1.02766
	3639		Low confidence	203.544	200.707	1.01414
growth arrest and dna-damage-inducible protein gadd45 beta (negative growth-regulatory protein myd118) (myeloid differentiation primary response protein myd118). [swissprot;acc:o75293]	1116	GADD45B	High confidence	251.863	258.829	1.02766
	3640		Low confidence	203.544	200.707	1.01414
growth arrest and dna-damage-inducible protein gadd45 gamma (cytokine responsive protein cr6). [swissprot;acc:o95257]	1113	GADD45G	High confidence	251.863	258.829	1.02766
	3637		Low confidence	203.534	200.693	1.01416
growth factor receptor-bound protein 2 (grb2 adapter protein) (sh2/sh3 adapter grb2) (ash protein). [swissprot;acc:p29354]	446	GRB2	High confidence	224.049	207.785	1.07827
	622		Low confidence	204.479	198.65	1.02934
growth hormone inducible transmembrane protein (dermal papilla derived protein 2) (my021 protein) (ptd010). [swissprot;acc:q9h3k2]	944	GHITM		204.752	199.775	1.02491
growth-arrest-specific protein 7 (gas-7). [swissprot;acc:o60861]	1395	GAS7	High confidence	218.47	213.876	1.02148
	2016		Low confidence	201.307	197.468	1.01944
grpe protein homolog 1, mitochondrial precursor (mt-grpe#1) (hmge). [swissprot;acc:q9hav7]	2199	GRPEL1		198.596	194.895	1.01899
	2511		High confidence	234.384	234.948	1.00241
grpe protein homolog 2, mitochondrial precursor (mt-grpe#2). [swissprot;acc:q8taa5]	2184	GRPEL2	Low confidence	198.61	194.903	1.01902
	2510		High confidence	234.384	234.948	1.00241
gtp binding protein 2. [refseq;acc:nm_019096]	1679	GTPBP2		216.899	213.889	1.01407
	1852		Low confidence	203.096	199.132	1.01991
gtp cyclohydrolase i (ec 3.5.4.16) (gtp-ch-i). [swissprot;acc:p30793]	2131	GCH1	High confidence	226.277	227.851	1.00696
	2947		Low confidence	199.54	196.215	1.01695
gtp-binding nuclear protein ran (tc4) (ran gtpase) (androgen receptor- associated protein 24). [swissprot;acc:p17080]	735	RANP1	High confidence	232.601	244.534	1.0513
	2884		Low confidence	202.423	199.021	1.01709
gtp-binding protein era homolog (hera) (fragment). [swissprot;acc:o75616]	833	ERAL1		204.064	198.895	1.02599
	1543		High confidence	213.546	209.965	1.01706
gtp-binding protein gem (gtp-binding mitogen-induced t-cell protein) (ras-like protein kir). [swissprot;acc:p55040]	1637	GEM	Low confidence	202.784	198.663	1.02074
gtp-binding protein rad (ras associated with diabetes) (rad1). [swissprot;acc:p55042]	1636	RRAD
gtp-binding protein sar1b. [swissprot;acc:q9y6b6]	712	SAR1B		201.401	195.979	1.02767
gtp:amp phosphotransferase mitochondrial (ec 2.7.4.10) (ak3) (adenylate kinase 3 alpha like 1). [swissprot;acc:q9uij7]	347	AK3	High confidence	242.14	265.697	1.09729
	4483		Low confidence	208.076	209.927	1.0089
guanidinoacetate n-methyltransferase (ec 2.1.1.2). [swissprot;acc:q14353]	2857	GAMT		199.28	195.921	1.01714
guanine deaminase (ec 3.5.4.3) (guanase) (guanine aminase) (guanine aminohydrolase) (gah) (p51-nedasin). [swissprot;acc:q9y2t3]	1989	GDA		200.113	196.283	1.01951
	2023		High confidence	208.601	210.464	1.00893
guanine nucleotide exchange factor mss4 (rab interacting factor). [swissprot;acc:p47224]	2777	RABIF		0.00001	0.00001	1
	4154		Low confidence	204.566	202.433	1.01054
guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]	109	GNB4	High confidence	266.933	333.281	1.24856
	3877		Low confidence	202.706	205.299	1.01279
guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]	82	GNB5	High confidence	267.636	335.359	1.25304
	2892		Low confidence	203.089	206.56	1.01709
guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [swissprot;acc:q9byb4]	2488	GNB1L		198.688	195.131	1.01823
	2761		High confidence	0.00001	0.00001	1
guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388]	959	no value		237.558	229.677	1.03431
	3504		Low confidence	201.402	198.439	1.01493

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.