MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	description	Rank	Hugo	Value Type	Network Comparison Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 294 to 343 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	red	green	network_comparison
60s ribosomal protein l36, mitochondrial precursor (l36mt) (brca1- interacting protein 1). [swissprot;acc:q9p0j6]	365	MRPL36	Divided	242.744	266.07	1.09609
60s ribosomal protein l37 (g1.16). [swissprot;acc:p02403]	567	RPL37	Subtracted	228.639	242.258	13.619
	635		Divided			1.05957
60s ribosomal protein l37a. [swissprot;acc:p12751]	2959	no value		0.00001	0.00001	1
			Subtracted	0	0	0
60s ribosomal protein l39. [swissprot;acc:p02404]	818			234.025	224.958	9.067
	859		Divided			1.04031
60s ribosomal protein l4 (l1). [swissprot;acc:p36578]	277	RPL4	Subtracted	239.277	262.434	23.157
	359		Divided			1.09678
60s ribosomal protein l5. [swissprot;acc:p46777]	244	RPL5	Subtracted	241.899	265.924	24.025
	326		Divided			1.09932
60s ribosomal protein l7. [swissprot;acc:p18124]	233	no value	Subtracted	235.727	259.984	24.257
	297		Divided			1.1029
60s ribosomal protein l8. [swissprot;acc:p25120]	783	RPL8	Subtracted	231.734	222.222	9.512
	834		Divided			1.0428
60s ribosomal protein l9. [swissprot;acc:p32969]	265	no value	Subtracted	240.243	263.798	23.555
	341		Divided			1.09805
65 kda yes-associated protein (yap65). [swissprot;acc:p46937]	1941	YAP1	Subtracted	219.26	217.193	2.067
	1986		Divided			1.00952
69 kda islet cell autoantigen (ica69) (islet cell autoantigen 1) (islet cell autoantigen p69) (icap69). [swissprot;acc:q05084]	3227	ICA1		0.00001	0.00001	1
			Subtracted	0	0	0
9 kda protein. [swissprot;acc:p13994]	1942	CCDC130		219.26	217.193	2.067
	1988		Divided			1.00952
a kindred of iglon. [refseq;acc:nm_173808]	792	NEGR1	Subtracted	212.386	221.785	9.399
	804		Divided			1.04425
a-kinase anchor protein 5 (a-kinase anchor protein 79 kda) (akap 79) (camp-dependent protein kinase regulatory subunit ii high affinity binding protein) (h21). [swissprot;acc:p24588]	2788	AKAP5		0.00001	0.00001	1
			Subtracted	0	0	0
a-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (a-raf-1) (proto-oncogene pks). [swissprot;acc:p10398]	957	ARAF	Divided	129.913	134.399	1.03453
	1372		Subtracted			4.486
aarf domain containing kinase 1. [refseq;acc:nm_020421]	1729	ADCK1		215.336	212.567	2.769
	1733		Divided			1.01303
aarf domain containing kinase 2; putative ubiquinone biosynthesis protein aarf. [refseq;acc:nm_052853]	1727	ADCK2	Subtracted			2.769
	1731		Divided			1.01303
aarf domain containing kinase 4. [refseq;acc:nm_024876]	1728	ADCK4	Subtracted			2.769
	1732		Divided			1.01303
abhydrolase domain containing protein 2 (protein phps1-2). [swissprot;acc:p08910]	1912	ABHD2	Subtracted	218.43	216.279	2.151
	1935		Divided			1.00995
abl-interactor 2; abl-interacting protein 1 (sh3-containing protein); abl binding protein 3; arg protein tyrosine kinase-binding protein; abl-interactor protein 2b; similar to spectrin sh3 domain binding protein 1. [refseq;acc:nm_005759]	1837	ABI2	Subtracted	217.077	214.702	2.375
	1845		Divided			1.01106
acetyl-coa acetyltransferase, mitochondrial precursor (ec 2.3.1.9) (acetoacetyl-coa thiolase) (t2). [swissprot;acc:p24752]	2306	ACAT1		191.571	192.544	1.00508
	2338		Subtracted			0.973
acetyl-coa carboxylase 1 (ec 6.4.1.2) (acc-alpha) [includes: biotin carboxylase (ec 6.3.4.14)]. [swissprot;acc:q13085]	2319	ACACA	Divided	194.842	195.8	1.00492
	2344		Subtracted			0.958
acetyl-coa carboxylase 2 (ec 6.4.1.2) (acc-beta) [includes: biotin carboxylase (ec 6.3.4.14)]. [swissprot;acc:o00763]	2315	ACACB	Divided	194.825	195.787	1.00494
	2341		Subtracted			0.962
acetyl-coenzyme a synthetase, cytoplasmic (ec 6.2.1.1) (acetate--coa ligase) (acyl-activating enzyme) (acetyl-coa synthetase) (acs) (acecs). [swissprot;acc:q9nr19]	2039	ACSS2	Divided	190.551	192.191	1.00861
	2085		Subtracted			1.64
acid ceramidase precursor (ec 3.5.1.23) (acylsphingosine deacylase) (n-acylsphingosine amidohydrolase) (ac) (putative 32 kda heart protein) (php32). [swissprot;acc:q13510]	1417	ASAH1		207.076	211.391	4.315
	1421		Divided			1.02084
acrc protein; putative nuclear protein. [refseq;acc:nm_052957]	2101	ACRC		211.71	213.27	1.00737

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.