MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2930 to 2979 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
1465	MTO1	mto1 protein homolog (cgi-02). [swissprot;acc:q9y2z2]	Divided	217.351	213.18	1.01957
1466	CHRNA6	neuronal acetylcholine receptor protein, alpha-6 chain precursor. [swissprot;acc:q15825]	Subtracted	171.231	167.177	4.054
	RTN2	reticulon protein 2 (neuroendocrine-specific protein-like 1) (nsp-like protein 1) (nspli). [swissprot;acc:o75298]	Divided	207.022	211.073	1.01957
1467	ISCU	nitrogen fixation cluster-like. [refseq;acc:nm_014301]	Subtracted	171.231	167.177	4.054
	MPP2	maguk p55 subfamily member 2 (mpp2 protein) (discs, large homolog 2). [swissprot;acc:q14168]	Divided	228.513	232.983	1.01956
1468	DRAP1	dr1-associated protein 1; negative cofactor 2 alpha; dr1-associated corepressor. [refseq;acc:nm_006442]		212.001	207.937	1.01954
	STARD13	star-related lipid transfer protein 13 (stard13) (start domain- containing protein 13) (46h23.2). [swissprot;acc:q9y3m8]	Subtracted	171.231	167.177	4.054
1469	RTN3	reticulon protein 3 (neuroendocrine-specific protein-like 2) (nsp-like protein ii) (nsplii). [swissprot;acc:o95197]	Divided	207.013	211.05	1.0195
	STARD8	star-related lipid transfer protein 8 (stard8) (start domain- containing protein 8). [swissprot;acc:q92502]	Subtracted	171.231	167.177	4.054
1470	CHRNA2	neuronal acetylcholine receptor protein, alpha-2 chain precursor. [swissprot;acc:q15822]
	QARS	glutaminyl-trna synthetase (ec 6.1.1.18) (glutamine--trna ligase) (glnrs). [swissprot;acc:p47897]	Divided	221.412	217.199	1.0194
1471	MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3; mapkap kinase 3. [refseq;acc:nm_004635]	Subtracted	171.231	167.177	4.054
	SRM	spermidine synthase (ec 2.5.1.16) (putrescine aminopropyltransferase) (spdsy). [swissprot;acc:p19623]	Divided	221.412	217.199	1.0194
1472	GARS	glycyl-trna synthetase (ec 6.1.1.14) (glycine--trna ligase) (glyrs). [swissprot;acc:p41250]
	MAPK14	mitogen-activated protein kinase 14 (ec 2.7.1.37) (mitogen-activated protein kinase p38alpha) (map kinase p38alpha) (cytokine suppressive anti-inflammatory drug binding protein) (csaid binding protein) (csbp) (max-interacting protein 2) (map kinase mxi2) (sapk2a). [swissprot;acc:q16539]	Subtracted	171.231	167.177	4.054
1473	CHRNA4	neuronal acetylcholine receptor protein, alpha-4 chain precursor. [swissprot;acc:p43681]
	EARS2	glutamyl trna synthetase. [sptrembl;acc:o14563]	Divided	221.412	217.199	1.0194
1474	CHRNA3	neuronal acetylcholine receptor protein, alpha-3 chain precursor. [swissprot;acc:p32297]	Subtracted	171.231	167.177	4.054
	RANBP5	importin beta-3 subunit (karyopherin beta-3 subunit) (ran-binding protein 5). [swissprot;acc:o00410]	Divided	218.582	214.427	1.01938
1475	KYNU	kynureninase (ec 3.7.1.3) (l-kynurenine hydrolase). [swissprot;acc:q16719]		181.882	178.438	1.0193
	SPHK2	sphingosine kinase 2 (ec 2.7.1.-) (sk 2) (spk 2). [swissprot;acc:q9nra0]	Subtracted	171.231	167.177	4.054
1476	RANBP6	ran-gtp binding protein (fragment). [sptrembl;acc:o60518]	Divided	218.591	214.457	1.01928
	RTN2	reticulon protein 2 (neuroendocrine-specific protein-like 1) (nsp-like protein 1) (nspli). [swissprot;acc:o75298]	Subtracted	207.022	211.073	4.051
1477	no value	transformer-2 protein homolog (tra-2 alpha). [swissprot;acc:q13595]	Divided	215.328	211.267	1.01922
	RTN3	reticulon protein 3 (neuroendocrine-specific protein-like 2) (nsp-like protein ii) (nsplii). [swissprot;acc:o95197]	Subtracted	207.013	211.05	4.037
1478	SFRS10	arginine/serine-rich splicing factor 10 (transformer-2-beta) (htra2- beta) (transformer 2 protein homolog) (silica-induced protein 41) (ra301). [swissprot;acc:q15815]	Divided	215.122	211.066	1.01922
	TRIP12	thyroid receptor interacting protein 12 (trip12). [swissprot;acc:q14669]	Subtracted	205.817	209.851	4.034
1479	DLSTP	dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor (ec 2.3.1.61) (e2) (e2k). [swissprot;acc:p36957]
	MPP6	maguk p55 subfamily member 6 (veli-associated maguk 1) (vam-1). [swissprot;acc:q9nzw5]	Divided	228.469	232.855	1.0192
1480	CPSF6	cleavage and polyadenylation specific factor 6, 68 kd subunit; pre-mrna cleavage factor im (68kd); cleavage and polyadenylation specific factor 6, 68kd subunit; pre-mrna cleavage factor i, 68kd subunit. [refseq;acc:nm_007007]		218.664	214.55	1.01918
	MAP3K7	mitogen-activated protein kinase kinase kinase 7 (ec 2.7.1.-) (transforming growth factor-beta-activated kinase 1) (tgf-beta- activated kinase 1). [swissprot;acc:o43318]	Subtracted	213.251	209.264	3.987
1481	ACTR1A	alpha-centractin (centractin) (centrosome-associated actin homolog) (actin-rpv) (arp1). [swissprot;acc:p42024]		225.148	221.177	3.971
	CDC23	cell division cycle protein 23; anaphase-promoting complex subunit 8. [refseq;acc:nm_004661]	Divided	208.432	204.516	1.01915
1482	ACTR1B	beta-centractin (actin-related protein 1b) (arp1b). [swissprot;acc:p42025]	Subtracted	225.148	221.177	3.971
	LSAMP	limbic system-associated membrane protein precursor (lsamp). [swissprot;acc:q13449]	Divided	224.354	220.15	1.0191
1483	PDHB	pyruvate dehydrogenase e1 component beta subunit, mitochondrial precursor (ec 1.2.4.1) (pdhe1-b). [swissprot;acc:p11177]		198.927	202.726
	RBM10	rna-binding protein 10 (rna binding motif protein 10) (dxs8237e). [swissprot;acc:p98175]	Subtracted	228.419	232.376	3.957
1484	CYCS	cytochrome c. [swissprot;acc:p00001]
	TMEM91	2-oxoisovalerate dehydrogenase alpha subunit, mitochondrial precursor (ec 1.2.4.4) (branched-chain alpha-keto acid dehydrogenase e1 component alpha chain) (bckdh e1-alpha). [swissprot;acc:p12694]	Divided	198.927	202.726	1.0191
1485	HS6ST2	heparan sulfate 6-o-sulfotransferase 2. [refseq;acc:nm_147174]	Subtracted	228.419	232.376	3.957
	RBPJ	j kappa-recombination signal binding protein (rbp-j kappa). [swissprot;acc:q06330]	Divided	207.877	203.989	1.01906
1486	HIVEP3	human immunodeficiency virus type i enhancer binding protein 3. [refseq;acc:nm_024503]
	HS6ST1	heparan sulfate 6-o-sulfotransferase; heparan-sulfate 6-sulfotransferase. [refseq;acc:nm_004807]	Subtracted	228.419	232.376	3.957
1487	FA2H	fatty acid hydroxylase domain containing 1. [refseq;acc:nm_024306]
	HIVEP1	zinc finger protein 40 (human immunodeficiency virus type i enhancer- binding protein 1) (hiv-ep1) (major histocompatibility complex binding protein 1) (mbp-1) (positive regulatory domain ii binding factor 1) (prdii-bf1). [swissprot;acc:p15822]	Divided	207.877	203.989	1.01906
1488	HIVEP2	human immunodeficiency virus type i enhancer-binding protein 2 (hiv-ep2). [swissprot;acc:p31629]
	WBP11	ww domain binding protein 11; npw38-binding protein npwbp; sh3 domain-binding protein snp70. [refseq;acc:nm_016312]	Subtracted	228.419	232.376	3.957
1489	ELAC2	elac homolog 2; putative prostate cancer susceptibility protein; elac (e. coli) homolog 2. [refseq;acc:nm_018127]
	MAP3K7	mitogen-activated protein kinase kinase kinase 7 (ec 2.7.1.-) (transforming growth factor-beta-activated kinase 1) (tgf-beta- activated kinase 1). [swissprot;acc:o43318]	Divided	213.251	209.264	1.01905
1490	PTRH2	protein cgi-147. [swissprot;acc:q9y3e5]		221.961	226.186	1.01903

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.