MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2908 to 2957 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	green	network_comparison
727	NUAK1	probable serine/threonine-protein kinase kiaa0537 (ec 2.7.1.-). [swissprot;acc:o60285]	Subtracted	High confidence	208.873	219.71	10.837
728	ALDH3B2	aldehyde dehydrogenase 8 (ec 1.2.1.5). [swissprot;acc:p48448]		Low confidence	209.59	215.023	5.433
	B3GNT1	n-acetyllactosaminide beta-1,3-n-acetylglucosaminyltransferase (ec 2.4.1.149) (poly-n-acetyllactosamine extension enzyme) (i-beta- 1,3-n-acetylglucosaminyltransferase) (ignt) (udp-glcnac:betagal beta- 1,3-n-acetylglucosaminyltransferase 6). [swissprot;acc:o43505]	Divided	High confidence	208.874	219.708	1.05187
			Subtracted				10.834
	IGF2BP2	igf-ii mrna-binding protein 2. [refseq;acc:nm_006548]	Divided	Low confidence	205.561	200.075	1.02742
729	no value	huntingtin interacting protein e; huntingtin interactor protein e. [refseq;acc:nm_007076]		High confidence	208.874	219.708	1.05187
			Subtracted				10.834
	MKI67IP	mki67 (fha domain) interacting nucleolar phosphoprotein; nucleolar phosphoprotein nopp34; nucleolar protein interacting with the fha domain of pki-67. [refseq;acc:nm_032390]		Low confidence	204.098	198.67	5.428
	MRPS16	28s ribosomal protein s16, mitochondrial precursor (mrp-s16) (cgi- 132). [swissprot;acc:q9y3d3]	Divided		205.65	200.165	1.0274
730	no value	u6 snrna-associated sm-like protein lsm7. [swissprot;acc:q9uk45]	Subtracted		201.325	195.897	5.428
	MRPS26	28s ribosomal protein s26, mitochondrial precursor (mrp-s26) (mrp- s13). [swissprot;acc:q9byn8]	Divided		206.555	201.05	1.02738
	TIMM10	mitochondrial import inner membrane translocase subunit tim10. [swissprot;acc:q9y5j8]		High confidence	208.874	219.708	1.05187
			Subtracted				10.834
731	FBXL10	protein containing cxxc domain 2. [refseq;acc:nm_032590]		Low confidence	202.951	208.378	5.427
	FH	fumarate hydratase, mitochondrial precursor (ec 4.2.1.2) (fumarase). [swissprot;acc:p07954]	Divided	High confidence	208.874	219.708	1.05187
			Subtracted				10.834
	PARS2	similar to trna synthetase class ii. [refseq;acc:nm_152268]	Divided	Low confidence	203.316	197.904	1.02735
732	no value	translin. [swissprot;acc:q15631]	Subtracted	High confidence	224.385	235.131	10.746
	G3BP2	ras-gtpase-activating protein binding protein 2 (gap sh3-domain binding protein 2) (g3bp-2). [swissprot;acc:q9un86]		Low confidence	210.933	216.358	5.425
	PPP1R3C	protein phosphatase 1, regulatory (inhibitor) subunit 5; phosphatase 1, regulatory inhibitor subunit 5. [refseq;acc:nm_005398]	Divided		203.592	198.172	1.02735
	SEPT8	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]		High confidence	124.434	118.318	1.05169
733	ACADVL	acyl-coa dehydrogenase, very-long-chain specific, mitochondrial precursor (ec 1.3.99.-) (vlcad). [swissprot;acc:p49748]			164	155.961	1.05154
	LIG1	dna ligase i (ec 6.5.1.1) (polydeoxyribonucleotide synthase [atp]). [swissprot;acc:p18858]	Subtracted	Low confidence	204.123	198.699	5.424
	MKI67IP	mki67 (fha domain) interacting nucleolar phosphoprotein; nucleolar phosphoprotein nopp34; nucleolar protein interacting with the fha domain of pki-67. [refseq;acc:nm_032390]	Divided		204.098	198.67	1.02732
	TSNAX	translin-associated protein x (translin-associated factor x). [swissprot;acc:q99598]	Subtracted	High confidence	224.385	235.131	10.746
734	no value	presenilin-like protein 2 (ec 3.4.99.-) (sppl2a protein). [swissprot;acc:q8tct8]	Divided		232.601	244.534	1.0513
	PQBP1	polyglutamine binding protein 1; nuclear protein containing ww domain 38 kd. [refseq;acc:nm_005710]	Subtracted		224.385	235.131	10.746
	SAR1B	gtp-binding protein sar1b. [swissprot;acc:q9y6b6]		Low confidence	201.401	195.979	5.422
	SEPT10	septin 10 isoform 1. [refseq;acc:nm_144710]	Divided		153.764	149.678	1.0273
735	HEMK1	hemk protein homolog (ec 2.1.1.-) (m.hsahemkp). [swissprot;acc:q9y5r4]	Subtracted	High confidence	229.045	218.343	10.702
	LIG1	dna ligase i (ec 6.5.1.1) (polydeoxyribonucleotide synthase [atp]). [swissprot;acc:p18858]	Divided	Low confidence	204.123	198.699	1.0273
	PPP1R3C	protein phosphatase 1, regulatory (inhibitor) subunit 5; phosphatase 1, regulatory inhibitor subunit 5. [refseq;acc:nm_005398]	Subtracted		203.592	198.172	5.42
	RANP1	gtp-binding nuclear protein ran (tc4) (ran gtpase) (androgen receptor- associated protein 24). [swissprot;acc:p17080]	Divided	High confidence	232.601	244.534	1.0513
736	no value	presenilin-like protein 1 (ec 3.4.99.-) (sppl2b protein). [swissprot;acc:q8tct7]
	MAD1L1	mad1-like 1; mad1 (mitotic arrest deficient, yeast, homolog)-like 1; mitotic-arrest deficient 1, yeast, homolog-like 1; tumor protein p53 inducible protein 9. [refseq;acc:nm_003550]	Subtracted	Low confidence	208.017	202.601	5.416
	N6AMT1	putative n6-dna-methyltransferase (ec 2.1.1.-) (protein pred28) (m.hsahemk2p). [swissprot;acc:q9y5n5]		High confidence	228.78	218.091	10.689
	PDCD11	rrp5 protein homolog (programmed cell death protein 11). [swissprot;acc:q14690]	Divided	Low confidence	202.639	197.261	1.02726
737	AGPAT3	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	Subtracted		192.166	186.751	5.415
	EXOC6B	exocyst complex component sec15b. [swissprot;acc:q9y2d4]		High confidence	221.968	211.326	10.642
	OTC	ornithine carbamoyltransferase, mitochondrial precursor (ec 2.1.3.3) (otcase) (ornithine transcarbamylase). [swissprot;acc:p00480]	Divided	Low confidence	179.918	175.156	1.02719
	SEPT10	septin 10 isoform 1. [refseq;acc:nm_144710]		High confidence	125.526	119.402	1.05129
738	EPS8L1	epidermal growth factor receptor pathway substrate 8-like protein 1 isoform c; epidermal growth factor receptor pathway substrate 8-related protein 1; eps8-related protein 1. [refseq;acc:nm_139204]		Low confidence	206.474	201.013	1.02717
	EXOC6	exocyst complex component sec15a. [swissprot;acc:q8tag9]	Subtracted	High confidence	222.138	211.503	10.635
	PARS2	similar to trna synthetase class ii. [refseq;acc:nm_152268]		Low confidence	203.316	197.904	5.412
	XAB2	xpa-binding protein 2 (hcnp protein) (pp3898). [swissprot;acc:q9hcs7]	Divided	High confidence	222.825	211.966	1.05123
739	LYPLA3	lysophospholipase 3 (lysosomal phospholipase a2); lcat-like lysophospholipase; likely ortholog of bovine lysosomal phospholipase a2; 1-o-acylceramide synthase; lysosomal phospholipase a2; lysophospholipase 3. [refseq;acc:nm_012320]		Low confidence	204.348	198.945	1.02716
	PDPK1	3-phosphoinositide dependent protein kinase-1 (ec 2.7.1.37) (hpdk1). [swissprot;acc:o15530]	Subtracted	High confidence	272.878	283.472	10.594
	PFAS	phosphoribosylformylglycinamidine synthase (ec 6.3.5.3) (fgam synthase) (fgams) (formylglycinamide ribotide amidotransferase) (fgarat) (formylglycinamide ribotide synthetase). [swissprot;acc:o15067]	Divided		223.58	235.027	1.0512
	STX1B	syntaxin 1b. [swissprot;acc:q15531]	Subtracted	Low confidence	211.432	206.021	5.411
740	no value	u2 small nuclear ribonucleoprotein auxiliary factor 35 kda subunit related-protein 1. [swissprot;acc:q15695]		High confidence	223.463	212.875	10.588

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.