MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Rank	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 30 to 79 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Value Type	Network Comparison Type	red	green	network_comparison
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	822	AGPAT4	Rooted	Divided	73.8577	78.5795	1.06393
	1048		Ranked		187.96	182.308	1.031
	1128			Subtracted			5.652
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	279	AGPAT3	Squared		30596.2	38919.9	8323.7
	308			Divided			1.27205
	318		Measured	Subtracted	7485.08	8543.66	1058.58
	513			Divided			1.14143
	616		Rooted	Subtracted	73.9102	78.6514	4.7412
	811			Divided			1.06415
	1043		Ranked		187.834	182.137	1.03128
	1121			Subtracted			5.697
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147]	3126	PLCB4	Measured	Divided	0.00001	0.00001	1
				Subtracted	0	0	0
			Ranked	Divided	0.00001	0.00001	1
				Subtracted	0	0	0
			Squared	Divided	0.00001	0.00001	1
				Subtracted	0	0	0
			Rooted	Divided	0.00001	0.00001	1
				Subtracted	0	0	0
10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]	588	HSPE1	Squared	Divided	23526.4	27879.3	1.18502
	688			Subtracted			4352.9
	1136		Measured	Divided	5790.65	6303.92	1.08864
	1140			Subtracted			513.27
	1902		Rooted		63.4353	65.2789	1.8436
	1907			Divided			1.02906
	1933		Ranked	Subtracted	211.633	213.703	2.07
	1963			Divided			1.00978
10-formyltetrahydrofolate dehydrogenase (ec 1.5.1.6) (10-fthfdh). [swissprot;acc:o75891]	2922	ALDH1L1	Measured		0.00001	0.00001	1
				Subtracted	0	0	0
			Ranked	Divided	0.00001	0.00001	1
				Subtracted	0	0	0
			Squared	Divided	0.00001	0.00001	1
				Subtracted	0	0	0
			Rooted	Divided	0.00001	0.00001	1
				Subtracted	0	0	0
14-3-3 protein beta/alpha (protein kinase c inhibitor protein-1) (kcip-1) (protein 1054). [swissprot;acc:p31946]	792	YWHAB	Squared		28551.5	32561.8	4010.3
	1143			Divided			1.14046
	1411		Measured		5812.02	6262.07	1.07743
	1422			Subtracted			450.05
	1943		Rooted	Divided	61.3337	63.0838	1.02853
	1987			Subtracted			1.7501
	2421		Ranked		220.681	221.425	0.744
	2439			Divided			1.00337
14-3-3 protein epsilon (mitochondrial import stimulation factor l subunit) (protein kinase c inhibitor protein-1) (kcip-1) (14-3-3e). [swissprot;acc:p42655]	3088	YWHAE	Measured		0.00001	0.00001	1
				Subtracted	0	0	0
			Ranked	Divided	0.00001	0.00001	1
				Subtracted	0	0	0
			Squared	Divided	0.00001	0.00001	1
				Subtracted	0	0	0
			Rooted	Divided	0.00001	0.00001	1

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.