MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	description	Network Comparison Type	Value Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 501 to 550 of 7460 in total

Value Type  : Measured
Interaction Map  : High confidence

Rank	description	Network Comparison Type	Filtered	green	red	network_comparison
126	calcyphosine. [swissprot;acc:q13938]	Divided	0	635.875	472.524	1.3457
	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]		1	18164.9	24250	1.33499
	pp3111 protein. [refseq;acc:nm_022156]	Subtracted	0	530	789	259
	rad50-interacting protein 1. [refseq;acc:nm_021930]		1	2394.5	450.5	1944
127	alcohol dehydrogenase class iii chi chain (ec 1.1.1.1) (glutathione- dependent formaldehyde dehydrogenase) (ec 1.2.1.1) (fdh). [swissprot;acc:p11766]		0	1759.22	2017.91	258.69
	lipopolysaccharide-binding protein precursor (lbp). [swissprot;acc:p18428]	Divided		64	86	1.34375
	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Subtracted	1	2394.5	450.5	1944
	transcription factor jun-d. [swissprot;acc:p17535]	Divided		7523.39	5638.2	1.33436
128	importin 9. [refseq;acc:nm_018085]	Subtracted	0	1397.66	1143.55	254.11
	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]	Divided	1	5810.82	4355.61	1.3341
	mitochondrial 28s ribosomal protein s22 (s22mt) (mrp-s22) (gk002). [swissprot;acc:p82650]		0	60.8613	81.504	1.33918
	t-complex protein 1, alpha subunit (tcp-1-alpha) (cct-alpha). [swissprot;acc:p17987]	Subtracted	1	12944.2	11004.2	1940
129	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]	Divided		5811.49	4358.13	1.33348
	nucleosome assembly protein 1-like 4 (nucleosome assembly protein 2) (nap2). [swissprot;acc:q99733]	Subtracted	0	1397.66	1143.55	254.11
	protein hspc134 (protein cda04). [swissprot;acc:q9by43]	Divided		454.837	606.485	1.33341
	protein phosphatase 1, regulatory (inhibitor) subunit 13b; apoptosis-stimulating protein of p53, 1. [refseq;acc:nm_015316]	Subtracted	1	13346.9	15274.9	1928
130	chromodomain y-like protein 2. [refseq;acc:nm_152342]		0	2799.81	3053.31	253.5
	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	Divided	1	2978.53	2234.68	1.33287
	maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]		0	56	42	1.33333
	p66 alpha. [refseq;acc:nm_017660]	Subtracted	1	10911.1	12839	1927.9
131	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	Divided		2978.57	2234.73	1.33285
	protein-tyrosine phosphatase, non-receptor type 1 (ec 3.1.3.48) (protein-tyrosine phosphatase 1b) (ptp-1b). [swissprot;acc:p18031]	Subtracted	0	4658.69	4912.01	253.32
	serpin b11. [swissprot;acc:q96p15]	Divided		56	42	1.33333
	transcription repressor p66 beta component of the mecp1 complex. [refseq;acc:nm_020699]	Subtracted	1	10911.1	12839	1927.9
132	cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]	Divided	0	56	42	1.33333
	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]		1	2980.35	2236.61	1.33253
	tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [swissprot;acc:p17735]	Subtracted		10911.1	12839	1927.9
	voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02]		0	2202	1949.36	252.64
133	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]	Divided		335	252	1.32937
	cell division protein kinase 3 (ec 2.7.1.-). [swissprot;acc:q00526]	Subtracted	1	10887.2	12798.9	1911.7
	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	Divided		17580.4	23421.5	1.33225
	testis-specific chromodomain protein y protein 2. [swissprot;acc:q9y6f7]	Subtracted	0	2784.59	3036.85	252.26
134	g2/mitotic-specific cyclin b2. [swissprot;acc:o95067]		1	10886	12796.8	1910.8
	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	Divided		16426.1	21785.2	1.32626
	mms19-like (met18 homolog, s. cerevisiae); homolog of yeast mms19; mms19 (met18 s. cerevisiae)-like. [refseq;acc:nm_022362]		0	346.751	260.986	1.32862
	testis-specific chromodomain y protein 1. [swissprot;acc:q9y6f8]	Subtracted		2784.08	3036.29	252.21
135	60s ribosomal protein l22 (epstein-barr virus small rna associated protein) (eber associated protein) (eap) (heparin binding protein hbp15). [swissprot;acc:p35268]			476.619	728.65	252.031
	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	Divided	1	16426.1	21785.2	1.32626
	rna polymerase i transcription factor rrn3. [refseq;acc:nm_018427]		0	613.614	814.485	1.32736
	transcription factor jun-b. [swissprot;acc:p17275]	Subtracted	1	7488.4	5579.18	1909.22
136	cell division protein kinase 2 (ec 2.7.1.-) (p33 protein kinase). [swissprot;acc:p24941]			10880.5	12787.6	1907.1
	glycine cleavage system h protein, mitochondrial precursor. [swissprot;acc:p23434]		0	1152.06	903.767	248.293
	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]	Divided	1	4763.34	3620.77	1.31556
	transcription factor e2f2 (e2f-2). [swissprot;acc:q14209]		0	1150.51	1526.38	1.3267
137	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]		1	4763.34	3620.77	1.31556
	g2/mitotic-specific cyclin b1. [swissprot;acc:p14635]	Subtracted		10879.9	12786.6	1906.7
	heat shock factor binding protein 1. [swissprot;acc:o75506]	Divided	0	1233.41	1631.18	1.3225
	ribonucleoside-diphosphate reductase m1 chain (ec 1.17.4.1) (ribonucleotide reductase large chain). [swissprot;acc:p23921]	Subtracted		7276.12	7520.78	244.66
138	60s ribosomal protein l17 (l23). [swissprot;acc:p18621]			1906.28	1663.73	242.55
	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	Divided	1	2094.3	2755.15	1.31555

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.