MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Rank	Hugo	Network Comparison Type	Value Type	Interaction Map	red	Filtered	green	network_comparison

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Showing element 30 to 79 of 66312 in total

Filtered  : 1

description	Rank	Hugo	Network Comparison Type	Value Type	Interaction Map	red	green	network_comparison
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]	1408	no value	Subtracted	Ranked	Low confidence	198.342	194.038	4.304
	4514			Squared		46617.7	45736	881.7
	4562		Divided					1.01928
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (ec 2.3.1.51) (1- agp acyltransferase 2) (1-agpat 2) (lysophosphatidic acid acyltransferase-beta) (lpaat-beta) (1-acylglycerol-3-phosphate o- acyltransferase 2). [swissprot;acc:o15120]	273	AGPAT2	Subtracted		High confidence	30826.5	39383.9	8557.4
	294		Divided					1.2776
	307		Subtracted	Measured		7556.75	8636.87	1080.12
	508		Divided					1.14293
	609		Subtracted	Rooted		74.3877	79.1931	4.8054
	773			Measured	Low confidence	8256.68	8587.03	330.35
	804		Divided	Rooted	High confidence	74.3877	79.1931	1.0646
	880			Measured	Low confidence	8256.68	8587.03	1.04001
	977		Subtracted	Rooted		73.5068	76.3467	2.8399
	1032		Divided	Ranked	High confidence	186.664	180.943	1.03162
	1084			Rooted	Low confidence	73.5068	76.3467	1.03863
	1115		Subtracted	Ranked	High confidence	186.664	180.943	5.721
	1322		Divided		Low confidence	198.322	194.014	1.0222
	1406		Subtracted					4.308
	4523			Squared		46616.1	45740.5	875.6
	4569		Divided					1.01914
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	210	AGPAT4	Subtracted	Measured		8530.51	9081.29	550.78
	237		Divided					1.06457
	280		Subtracted	Squared	High confidence	30566.4	38866.5	8300.1
	311		Divided					1.27154
	319		Subtracted	Measured		7477	8532.02	1055.02
	331			Rooted	Low confidence	75.8843	79.5804	3.6961
	378		Divided					1.04871
	514			Measured	High confidence	7477	8532.02	1.1411
	588			Ranked	Low confidence	191.507	185.859	1.03039
	631		Subtracted	Rooted	High confidence	73.8577	78.5795	4.7218
	664			Ranked	Low confidence	191.507	185.859	5.648
	822		Divided	Rooted	High confidence	73.8577	78.5795	1.06393
	1048			Ranked		187.96	182.308	1.031
	1128		Subtracted					5.652
	3936			Squared	Low confidence	46138.2	47372.8	1234.6
	4138		Divided					1.02676
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	230	AGPAT3	Subtracted	Measured		8492.92	9018.94	526.02
	252		Divided					1.06194
	279		Subtracted	Squared	High confidence	30596.2	38919.9	8323.7
	308		Divided					1.27205
	318		Subtracted	Measured		7485.08	8543.66	1058.58
	369			Rooted	Low confidence	75.6219	79.1997	3.5778
	427		Divided					1.04731
	513			Measured	High confidence	7485.08	8543.66	1.14143
	616		Subtracted	Rooted		73.9102	78.6514	4.7412
	637		Divided	Ranked	Low confidence	192.166	186.751	1.029
	737		Subtracted					5.415
	811		Divided	Rooted	High confidence	73.9102	78.6514	1.06415
	1043			Ranked		187.834	182.137	1.03128
	1121		Subtracted					5.697
	4331			Squared	Low confidence	46049.4	47088.3	1038.9

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.