MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Network Comparison Type	Gene	Rank	Hugo	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 2891 to 2940 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Network Comparison Type	Rank	Hugo	Value Type	red	green	network_comparison
autoantigen ngp-1. [swissprot;acc:q13823]	Divided	670	GNL2	Ranked	250.302	236.817	1.05694
		1328		Squared	14345.8	16176.5	1.12761
	Subtracted	573		Ranked	250.302	236.817	13.485
		692		Rooted	49.4756	53.9896	4.514
		1161		Measured	3766.14	4274.79	508.65
		2139		Squared	14345.8	16176.5	1830.7
autophagy protein 12-like (apg12-like). [swissprot;acc:o94817]	Divided	85	ATG12		67438.6	40697	1.65709
		203		Measured	11757.8	9352.11	1.25723
		643		Rooted	87.4586	81.0798	1.07867
		1729		Ranked	187.582	190.028	1.01304
	Subtracted	112		Measured	11757.8	9352.11	2405.69
		114		Squared	67438.6	40697	26741.6
		385		Rooted	87.4586	81.0798	6.3788
		1816		Ranked	187.582	190.028	2.446
autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0]	Divided	132	ATG5	Squared	36359.2	24466.8	1.48606
		414		Measured	6744.05	5815.13	1.15974
		1540		Ranked	240.077	236.015	1.01721
		2472		Rooted	60.9339	60.1805	1.01252
	Subtracted	210		Squared	36359.2	24466.8	11892.4
		410		Measured	6744.05	5815.13	928.92
		1454		Ranked	240.077	236.015	4.062
		2484		Rooted	60.9339	60.1805	0.7534
axonemal dynein light intermediate polypeptide 1 (inner dynein arm light chain, axonemal) (hp28). [swissprot;acc:o14645]	Divided	401	DNALI1	Squared	33044.3	40524.8	1.22638
		792		Measured	6772.75	7526.2	1.11125
		1264		Rooted	67.018	70.0209	1.04481
		2003		Ranked	208.315	206.41	1.00923
	Subtracted	312		Squared	33044.3	40524.8	7480.5
		587		Measured	6772.75	7526.2	753.45
		1137		Rooted	67.018	70.0209	3.0029
		2002		Ranked	208.315	206.41	1.905
b-cell cll/lymphoma 6, member b (zinc finger protein); zinc finger protein 62. [refseq;acc:nm_181844]	Divided	251	BCL6B	Squared	69165.6	52992.1	1.30521
		1559		Ranked	196.191	192.996	1.01655
		1633		Measured	9899.79	9251.2	1.07011
		2730		Rooted	78.2048	78.1394	1.00084
	Subtracted	168		Squared	69165.6	52992.1	16173.5
		745		Measured	9899.79	9251.2	648.59
		1632		Ranked	196.191	192.996	3.195
		2726		Rooted	78.2048	78.1394	0.0654
b-cell lymphoma 3-encoded protein (bcl-3 protein). [swissprot;acc:p20749]	Divided	1397	BCL3	Squared	50598.8	45106.3	1.12177
		2571		Rooted	72.5769	73.2309	1.00901
		2655		Ranked	201.445	201.667	1.0011
		2658		Measured	8278.73	8211.05	1.00824
	Subtracted	454		Squared	50598.8	45106.3	5492.5
		2508		Rooted	72.5769	73.2309	0.654
		2638		Measured	8278.73	8211.05	67.68
		2661		Ranked	201.445	201.667	0.222
b-cell lymphoma 6 protein (bcl-6) (zinc finger protein 51) (laz-3 protein) (bcl-5). [swissprot;acc:p41182]	Divided	253	BCL6	Squared	69165	52991.7	1.3052
		1556		Ranked	196.192	192.996	1.01656
		1635		Measured	9899.73	9251.16	1.07011
		2732		Rooted	78.2046	78.1392	1.00084

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.