MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2808 to 2857 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
1404	SF3B4	splicing factor 3b subunit 4 (spliceosome associated protein 49) (sap 49) (sf3b50) (pre-mrna splicing factor sf3b 49 kda subunit). [swissprot;acc:q15427]	High confidence	232.752	237.65	1.02104
1405	CYR61	cyr61 protein precursor (cysteine-rich, angiogenic inducer, 61) (insulin-like growth factor-binding protein 10) (gig1 protein). [swissprot;acc:o00622]	Low confidence	208.227	203.771	1.02187
	EIF3C	eukaryotic translation initiation factor 3 subunit 8 (eif3 p110) (eif3c). [swissprot;acc:q99613]	High confidence	245.532	240.483	1.021
1406	MPPED2	fetal brain protein 239 (239fb). [swissprot;acc:q15777]	Low confidence	204.115	199.746	1.02187
	NR6A1	orphan nuclear receptor nr6a1 (germ cell nuclear factor) (gcnf) (retinoid receptor-related testis specific receptor) (rtr). [swissprot;acc:q15406]	High confidence	212.833	208.456	1.021
1407	PYCR1	pyrroline-5-carboxylate reductase (ec 1.5.1.2) (p5cr) (p5c reductase). [swissprot;acc:p32322]	Low confidence	197.603	193.375	1.02186
	WDFY1	wd repeat and fyve domain containing 1 isoform 1; phosphoinositide-binding protein sr1; wd40 and fyve domain containing 1. [refseq;acc:nm_020830]	High confidence	206.104	210.424	1.02096
1408	EARS2	glutamyl trna synthetase. [sptrembl;acc:o14563]	Low confidence	196.216	192.019	1.02186
	STIM1	stromal interaction molecule 1 precursor. [swissprot;acc:q13586]	High confidence	206.102	210.42	1.02095
1409	MED30	trap/mediator complex component trap25. [refseq;acc:nm_080651]
	NFIL3	nuclear factor, interleukin 3 regulated. [refseq;acc:nm_005384]	Low confidence	195.821	191.636	1.02184
1410	RALGDS	ral guanine nucleotide dissociation stimulator (ralgef) (ralgds). [swissprot;acc:q12967]		199.829	195.558
	WDFY2	wd repeat- and fyve domain-containing protein 2; wd40 and fyve domain containing 2. [refseq;acc:nm_052950]	High confidence	206.1	210.417	1.02095
1411	NUDT14	uridine diphosphate glucose pyrophosphatase. [refseq;acc:nm_177533]	Low confidence	202.848	198.516	1.02182
	PAK4	serine/threonine-protein kinase pak 4 (ec 2.7.1.-) (p21-activated kinase 4) (pak-4). [swissprot;acc:o96013]	High confidence	206.102	210.42	1.02095
1412	PIN1	peptidyl-prolyl cis-trans isomerase nima-interacting 1 (ec 5.2.1.8) (rotamase pin1) (ppiase pin1). [swissprot;acc:q13526]	Low confidence	200.614	196.33	1.02182
	REEP5	polyposis locus protein 1 (tb2 protein). [swissprot;acc:q00765]	High confidence	206.102	210.42	1.02095
1413	ACADM	acyl-coa dehydrogenase, medium-chain specific, mitochondrial precursor (ec 1.3.99.3) (mcad). [swissprot;acc:p11310]
	WISP1	wnt1 inducible signaling pathway protein 1 isoform 1 precursor; wnt-1 signaling pathway protein 1; wnt1 signaling pathway protein 1; wnt-1 inducible signaling pathway protein 1. [refseq;acc:nm_003882]	Low confidence	208.214	203.768	1.02182
1414	HDAC6	histone deacetylase 6 (hd6). [swissprot;acc:q9ubn7]		202.848	198.516
	REEP6	polyposis locus protein 1-like 1; likely ortholog of mouse polyposis locus protein 1-like 1. [refseq;acc:nm_138393]	High confidence	206.102	210.42	1.02095
1415	PSAT1	phosphoserine aminotransferase (ec 2.6.1.52) (psat). [swissprot;acc:q9y617]	Low confidence	189.82	185.769	1.02181
	STIM2	stromal interaction molecule 2 precursor. [swissprot;acc:q9p246]	High confidence	206.102	210.42	1.02095
1416	no value	apoptosis inhibitor fksg2. [swissprot;acc:q9hau6]	Low confidence	199.817	195.566	1.02174
	PAK7	serine/threonine-protein kinase pak 7 (ec 2.7.1.-) (p21-activated kinase 7) (pak-7) (pak-5). [swissprot;acc:q9p286]	High confidence	206.102	210.42	1.02095
1417	CPA5	carboxypeptidase a5. [refseq;acc:nm_080385]		203.979	208.229	1.02084
	RAB1C	ras-related protein rab-1b. [swissprot;acc:q9h0u4]	Low confidence	201.279	196.999	1.02173
1418	BRUNOL5	bruno-like 5, rna binding protein; rna-binding protein brunol-5; cug-bp and etr-3 like factor 5. [refseq;acc:nm_021938]		202.784	198.471
	CPB1	carboxypeptidase b precursor (ec 3.4.17.2) (pancreas-specific protein) (pasp). [swissprot;acc:p15086]	High confidence	203.979	208.229	1.02084
1419	BRUNOL6	bruno-like 6, rna binding protein; rna-binding protein brunol-6. [refseq;acc:nm_052840]	Low confidence	202.785	198.472	1.02173
	SLC3A1	neutral and basic amino acid transport protein rbat (b(0,+)-type amino acid transport protein) (nbat) (d2h). [swissprot;acc:q07837]	High confidence	203.979	208.229	1.02084
1420	ACY1	aminoacylase-1 (ec 3.5.1.14) (n-acyl-l-amino-acid amidohydrolase) (acy-1). [swissprot;acc:q03154]
	BRUNOL4	bruno-like 4, rna binding protein; rna-binding protein brunol-5; cug-bp and etr-3 like factor 4. [refseq;acc:nm_020180]	Low confidence	202.785	198.472	1.02173
1421	ASAH1	acid ceramidase precursor (ec 3.5.1.23) (acylsphingosine deacylase) (n-acylsphingosine amidohydrolase) (ac) (putative 32 kda heart protein) (php32). [swissprot;acc:q13510]	High confidence	207.076	211.391	1.02084
	DRAP1	dr1-associated protein 1; negative cofactor 2 alpha; dr1-associated corepressor. [refseq;acc:nm_006442]	Low confidence	202.29	197.991	1.02171
1422	AKAP13	lbc oncogene (p47) (lymphoid blast crisis oncogene). [swissprot;acc:q12802]
	CPA1	carboxypeptidase a1 precursor (ec 3.4.17.1). [swissprot;acc:p15085]	High confidence	203.979	208.229	1.02084
1423	no value	cysteine-rich protein 1 (cysteine-rich intestinal protein) (crip) (cysteine-rich heart protein) (hcrhp). [swissprot;acc:p50238]		221.152	216.659	1.02074
	TPT1	translationally controlled tumor protein (tctp) (p23) (histamine- releasing factor) (hrf). [swissprot;acc:p13693]	Low confidence	199.796	195.55	1.02171
1424	ATP1A1	sodium/potassium-transporting atpase alpha-1 chain precursor (ec 3.6.3.9) (sodium pump 1) (na+/k+ atpase 1). [swissprot;acc:p05023]	High confidence	214.717	219.157	1.02068
	OCRL	inositol polyphosphate 5-phosphatase ocrl-1 (ec 3.1.3.36) (lowe's oculocerebrorenal syndrome protein). [swissprot;acc:q01968]	Low confidence	201.699	197.413	1.02171
1425	ARHGEF2	rho guanine nucleotide exchange factor 2 (gef-h1 protein) (proliferating cell nucleolar antigen p40). [swissprot;acc:q92974]		202.29	197.991
	CTSL2	cathepsin l2 precursor (ec 3.4.22.43) (cathepsin v) (cathepsin u). [swissprot;acc:o60911]	High confidence	214.717	219.157	1.02068
1426	CTSL1	cathepsin l precursor (ec 3.4.22.15) (major excreted protein) (mep). [swissprot;acc:p07711]
	WISP3	wnt1 inducible signaling pathway protein 3 isoform 1; wnt-1 signaling pathway protein 3; wnt1 signaling pathway protein 3; wnt-1 inducible signaling pathway protein 3. [refseq;acc:nm_003880]	Low confidence	208.184	203.761	1.02171
1427	ARHGEF18	rho-specific guanine nucleotide exchange factor p114. [refseq;acc:nm_015318]		202.29	197.991
	ATP1A3	sodium/potassium-transporting atpase alpha-3 chain (ec 3.6.3.9) (sodium pump 3) (na+/k+ atpase 3) (alpha(iii)). [swissprot;acc:p13637]	High confidence	214.717	219.157	1.02068
1428	ATP1A2	sodium/potassium-transporting atpase alpha-2 chain precursor (ec 3.6.3.9) (sodium pump 2) (na+/k+ atpase 2). [swissprot;acc:p50993]
	KEAP1	kelch-like ech-associated protein 1 (cytosolic inhibitor of nrf2). [swissprot;acc:q14145]	Low confidence	203.84	199.508	1.02171
1429	SALL2	sal-like protein 2 (zinc finger protein sall2) (hsal2). [swissprot;acc:q9y467]		203.208	198.892	1.0217

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.