MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2801 to 2850 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
701	atpase, h+ transporting, lysosomal 38kda, v0 subunit d isoform 2. [refseq;acc:nm_152565]	Squared	25852.2	30258.6	1.17045
	disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490]	Ranked	220.438	209.118	1.05413
	importin-alpha re-exporter (chromosome segregation 1-like protein) (cellular apoptosis susceptibility protein). [swissprot;acc:p55060]	Measured	7802.31	8731.82	1.11913
	ras-related protein rab-37. [swissprot;acc:q96ax2]	Rooted	51.4945	48.0189	1.07238
702	putative adenosylhomocysteinase 2 (ec 3.3.1.1) (s-adenosyl-l- homocysteine hydrolase) (adohcyase). [swissprot;acc:o43865]	Ranked	220.438	209.118	1.05413
	ras-related protein rab-26. [swissprot;acc:q9ulw5]	Rooted	51.4945	48.0189	1.07238
	sh3-containing grb2-like protein 3 (sh3 domain protein 2c) (een-b2). [swissprot;acc:q99963]	Measured	7067.46	7909.27	1.11911
	vacuolar atp synthase 16 kda proteolipid subunit (ec 3.6.3.14). [swissprot;acc:p27449]	Squared	25114	29386	1.1701
703	dna-directed rna polymerase ii 33 kda polypeptide (ec 2.7.7.6) (rpb3) (rna polymerase ii subunit 3) (rpb33) (rpb31). [swissprot;acc:p19387]	Rooted	51.4945	48.0189	1.07238
	limkain b1. [refseq;acc:nm_019081]	Ranked	220.438	209.118	1.05413
	nascent-polypeptide-associated complex alpha polypeptide. [refseq;acc:nm_005594]	Measured	6912.56	7735.12	1.11899
	sarcoglycan zeta; zeta-sarcoglycan. [refseq;acc:nm_139167]	Squared	25114	29386	1.1701
704	alpha-nac protein. [sptrembl;acc:q9h009]	Measured	6912.27	7734.68	1.11898
	golgi complex associated protein 1; golgi resident protein gcp60; peripherial benzodiazepine receptor associated protein; golgi phosphoprotein 1; pbr associated protein; pka (rialpha)-associated protein. [refseq;acc:nm_022735]	Squared	25114	29386	1.1701
	putative adenosylhomocysteinase 3 (ec 3.3.1.1) (s-adenosyl-l- homocysteine hydrolase) (adohcyase). [swissprot;acc:q96hn2]	Ranked	220.438	209.118	1.05413
	syntaxin 10 (syn10). [swissprot;acc:o60499]	Rooted	57.2102	53.3508	1.07234
705	cellular repressor of e1a-stimulated genes. [refseq;acc:nm_003851]	Ranked	220.438	209.118	1.05413
	delta-sarcoglycan (sg-delta) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q92629]	Squared	25114	29386	1.1701
	small gtp-binding tumor suppressor 1. [refseq;acc:nm_145173]	Measured	6912.09	7734.41	1.11897
	syntaxin 6. [swissprot;acc:o43752]	Rooted	57.2202	53.3639	1.07226
706	cellular modulator of immune recognition. [refseq;acc:nm_145021]	Squared	25114	29386	1.1701
	di-ras2. [refseq;acc:nm_017594]	Measured	6912.08	7734.39	1.11897
	disks large-associated protein 3 (dap-3) (sap90/psd-95-associated protein 3) (sapap3) (psd-95/sap90 binding protein 3) (fragment). [swissprot;acc:o95886]	Ranked	220.438	209.118	1.05413
	signal recognition particle 68 kda protein (srp68). [swissprot;acc:q9uhb9]	Rooted	60.6572	64.9858	1.07136
707	c18b11 homolog (44.9kd). [refseq;acc:nm_152260]	Measured	5317.78	5944.25	1.11781
	kininogen precursor (alpha-2-thiol proteinase inhibitor) [contains: bradykinin]. [swissprot;acc:p01042]	Ranked	220.438	209.118	1.05413
	mitochondrial import receptor subunit tom20 homolog (mitochondrial 20 kda outer membrane protein) (outer mitochondrial membrane receptor tom20). [swissprot;acc:q15388]	Rooted	74.8348	80.1352	1.07083
	vacuolar atp synthase 21 kda proteolipid subunit (ec 3.6.3.14) (hatpl). [swissprot;acc:q99437]	Squared	25114	29386	1.1701
708	disks large-associated protein 2 (dap-2) (sap90/psd-95-associated protein 2) (sapap2) (psd-95/sap90 binding protein 2) (fragment). [swissprot;acc:q9p1a6]	Ranked	220.438	209.118	1.05413
	peroxisomal farnesylated protein (33 kda housekeeping protein) (peroxin 19). [swissprot;acc:p40855]	Rooted	74.8348	80.1352	1.07083
	triosephosphate isomerase (ec 5.3.1.1) (tim). [swissprot;acc:p00938]	Squared	19970	23366.8	1.1701
	z-protein (protein cgi-119) (s1r protein). [swissprot;acc:q9hc24]	Measured	5317.78	5944.25	1.11781
709	ferritin light chain (ferritin l subunit). [swissprot;acc:p02792]	Ranked	220.438	209.118	1.05413
	gamma-sarcoglycan (gamma-sg) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q13326]	Squared	25114	29386	1.1701
	oligopeptide transporter, small intestine isoform (peptide transporter 1) (intestinal h+/peptide cotransporter) (solute carrier family 15, member 1). [swissprot;acc:p46059]	Rooted	80.4069	86.1018	1.07083
	pp1201 protein. [refseq;acc:nm_022152]	Measured	5317.78	5944.25	1.11781
710	disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0]	Ranked	220.438	209.118	1.05413
	lifeguard; kiaa0950 protein. [refseq;acc:nm_012306]	Measured	5317.78	5944.25	1.11781
	ring finger protein 25 (ec 6.3.2.-). [swissprot;acc:q96bh1]	Squared	51519.3	44060.4	1.16929
	son of sevenless protein homolog 2 (sos-2). [swissprot;acc:q07890]	Rooted	69.2869	74.1856	1.0707
711	dynein intermediate chain 2, cytosolic (dh ic-2) (cytoplasmic dynein intermediate chain 2). [swissprot;acc:q13409]		58.3914	62.5196
	hexaprenyldihydroxybenzoate methyltransferase, mitochondrial precursor (ec 2.1.1.114) (dihydroxyhexaprenylbenzoate methyltransferase) (3,4- dihydroxy-5-hexaprenylbenzoate methyltransferase) (dhhb methyltransferase) (dhhb-mt) (dhhb-mtase). [swissprot;acc:q9nzj6]	Squared	25626.4	29950.3	1.16873
	sterol regulatory element binding protein-2 (srebp-2) (sterol regulatory element-binding transcription factor 2). [swissprot;acc:q12772]	Measured	5317.78	5944.25	1.11781
	tyrosyl-trna synthetase (ec 6.1.1.1) (tyrosyl--trna ligase) (tyrrs). [swissprot;acc:p54577]	Ranked	232.468	245.048	1.05411
712	atp synthase coupling factor b, mitochondrial precursor. [swissprot;acc:q99766]	Squared	25626.4	29950.3	1.16873
	ferritin heavy polypeptide-like 17. [swissprot;acc:q9bxu8]	Ranked	220.431	209.123	1.05407
	sterol regulatory element binding protein-1 (srebp-1) (sterol regulatory element-binding transcription factor 1). [swissprot;acc:p36956]	Measured	5317.78	5944.25	1.11781
	vinculin (metavinculin). [swissprot;acc:p18206]	Rooted	62.9163	67.3603	1.07063
713	dendritic cell protein. [refseq;acc:nm_006360]	Ranked	223.121	211.685	1.05402
	guanine deaminase (ec 3.5.4.3) (guanase) (guanine aminase) (guanine aminohydrolase) (gah) (p51-nedasin). [swissprot;acc:q9y2t3]	Squared	25626.4	29950.3	1.16873

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.