MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 280 to 329 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
140	SPOCK2	testican-2 precursor. [swissprot;acc:q92563]	Low confidence	220.222	234.047	1.06278
141	ARHGEF7	rho guanine nucleotide exchange factor 7 (pak-interacting exchange factor beta) (beta-pix) (cool-1) (p85). [swissprot;acc:q14155]		219.344	206.52	1.0621
	RRAGC	ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157]	High confidence	59	49	1.20408
142	MAN1B1	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ec 3.2.1.113) (er alpha-1,2-mannosidase) (mannosidase alpha class 1b member 1) (man9glcnac2-specific processing alpha-mannosidase). [swissprot;acc:q9ukm7]	Low confidence	211.056	198.732	1.06201
	RRAGB	ras-related gtp binding b short isoform; gtp-binding protein ragb. [refseq;acc:nm_006064]	High confidence	59	49	1.20408
143	ANLN	anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]
	PSEN2	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	Low confidence	211.056	198.732	1.06201
144	FBXW7	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]
	KCNIP1	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	High confidence	265.686	319.651	1.20312
145	KCNIP4	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]		265.639	319.546	1.20293
	PSEN1	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	Low confidence	211.056	198.732	1.06201
146	KCNIP2	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]	High confidence	265.632	319.531	1.20291
	NDUFS4	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]	Low confidence	226.892	213.661	1.06193
147	no value	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	High confidence	50.7983	42.3003	1.2009
	ARHGEF6	rho guanine nucleotide exchange factor 6 (pak-interacting exchange factor alpha) (alpha-pix) (cool-2). [swissprot;acc:q15052]	Low confidence	219.273	206.507	1.06182
148	SENP8	sentrin-specific protease 8 (ec 3.4.22.-) (sentrin/sumo-specific protease senp8) (cysteine protease fksg8). [swissprot;acc:q96ld8]		210.579	198.33	1.06176
	UNC84A	sad1/unc-84 protein-like 1. [swissprot;acc:o94901]	High confidence	296.677	247.559	1.19841
149	no value	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]		142	170	1.19718
	NEDD8	ubiquitin-like protein nedd8. [swissprot;acc:q15843]	Low confidence	210.579	198.33	1.06176
150	MYO5B	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	High confidence	55	46	1.19565
	PLK1	serine/threonine-protein kinase plk (ec 2.7.1.-) (plk-1) (serine- threonine protein kinase 13) (stpk13). [swissprot;acc:p53350]	Low confidence	206.516	194.554	1.06148
151	CTSZ	cathepsin z precursor (ec 3.4.22.-) (cathepsin x) (cathepsin p). [swissprot;acc:q9ubr2]
	MYO5C	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	High confidence	55	46	1.19565
152	no value	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]
	HMG20A	high-mobility group 20a. [refseq;acc:nm_018200]	Low confidence	202.934	191.187	1.06144
153	RAB11FIP4	rab11-family interacting protein 4. [refseq;acc:nm_032932]		183.27	172.702	1.06119
	RBM15B	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	High confidence	249.663	298.263	1.19466
154	RAB11FIP3	eferin. [swissprot;acc:o75154]	Low confidence	183.27	172.702	1.06119
	RGS19	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	High confidence	249.663	298.263	1.19466
155	CTSL2	cathepsin l2 precursor (ec 3.4.22.43) (cathepsin v) (cathepsin u). [swissprot;acc:o60911]	Low confidence	211.818	199.734	1.0605
	RBM15	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	High confidence	249.663	298.263	1.19466
156	CTSL1	cathepsin l precursor (ec 3.4.22.15) (major excreted protein) (mep). [swissprot;acc:p07711]	Low confidence	211.808	199.761	1.06031
	RGS20	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	High confidence	249.663	298.263	1.19466
157	LBX1	transcription factor lbx1. [swissprot;acc:p52954]
	XKR7	dj310o13.4 (novel protein similar to predicted c. elegans and c. intestinalis proteins) (fragment). [sptrembl;acc:q9nug5]	Low confidence	178.507	168.371	1.0602
158	DNAJC8	dnaj homolog subfamily c member 8 (splicing protein spf31) (hspc315). [swissprot;acc:o75937]		219.838	207.417	1.05988
	GPSM2	mosaic protein lgn. [swissprot;acc:p81274]	High confidence	249.663	298.263	1.19466
159	GGNBP2	c3hc4-type zinc finger protein; likely ortholog of mouse dioxin inducible factor 3. [refseq;acc:nm_024835]	Low confidence	219.838	207.417	1.05988
	RGS17	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	High confidence	249.663	298.263	1.19466
160	APC	adenomatous polyposis coli protein (apc protein). [swissprot;acc:p25054]	Low confidence	222.31	235.538	1.0595
	GNAO1	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	High confidence	249.663	298.263	1.19466
161	APC2	adenomatous polyposis coli like. [refseq;acc:nm_005883]	Low confidence	222.34	235.547	1.0594
	RAP1GAP	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	High confidence	249.663	298.263	1.19466
162	DAD1	defender against cell death 1 (dad-1). [swissprot;acc:p46966]	Low confidence	197.99	186.913	1.05926
	NOSTRIN	nostrin. [refseq;acc:nm_052946]	High confidence	209.299	249.187	1.19058
163	SNF8	eap30 subunit of ell complex. [refseq;acc:nm_007241]
	VPS41	vacuolar assembly protein vps41 homolog (s53). [swissprot;acc:p49754]	Low confidence	202.698	191.393	1.05907
164	PPM1B	protein phosphatase 2c beta isoform (ec 3.1.3.16) (pp2c-beta). [swissprot;acc:o75688]		196.714	185.758	1.05898
	SLC39A6	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	High confidence	209.299	249.187	1.19058
165	CAPN1	calpain 1, large [catalytic] subunit (ec 3.4.22.17) (calcium-activated neutral proteinase) (canp) (mu-type) (mucanp) (micromolar-calpain). [swissprot;acc:p07384]	Low confidence	222.508	210.345	1.05782

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.