MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2651 to 2700 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Interaction Map	red	green	network_comparison
1326	dj947l8.1.6 (novel cub and sushi (scr repeat) domain protein) (fragment). [sptrembl;acc:q9h4w2]	CSMD1	High confidence	218.509	213.648	1.02275
	pre-mrna splicing factor atp-dependent rna helicase prp16 (atp- dependent rna helicase ddx38) (deah-box protein 38). [swissprot;acc:q92620]	DHX38	Low confidence	202.039	197.654	1.02219
1327	dnaj homolog subfamily b member 5 (heat shock protein hsp40-3) (heat shock protein cognate 40) (hsc40) (hsp40-2). [swissprot;acc:o75953]	DNAJB5		201.908	197.525
	zinc finger protein zic 4 (zinc finger protein of the cerebellum 4) (fragment). [swissprot;acc:q8n9l1]	ZIC4	High confidence	218.509	213.648	1.02275
1328	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (ec 2.3.1.51) (1- agp acyltransferase 1) (1-agpat 1) (lysophosphatidic acid acyltransferase-alpha) (lpaat-alpha) (1-acylglycerol-3-phosphate o- acyltransferase 1) (g15 protein). [swissprot;acc:q99943]	no value	Low confidence	198.342	194.038	1.02218
	calcipressin 2 (thyroid hormone-responsive protein zaki-4) (down syndrome candidate region 1-like 1) (myocyte-enriched calcineurin interacting protein 2) (mcip2). [swissprot;acc:q14206]	RCAN2	High confidence	218.509	213.649	1.02275
1329	carboxypeptidase a1 precursor (ec 3.4.17.1). [swissprot;acc:p15085]	CPA1	Low confidence	187.586	183.516	1.02218
	dj947l8.1.1 (novel cub and sushi (scr repeat) domain protein) (fragment). [sptrembl;acc:q9h4v7]	no value	High confidence	218.509	213.648	1.02275
1330	calcipressin 1 (down syndrome critical region protein 1) (myocyte- enriched calcineurin interacting protein 1) (mcip1) (adapt78). [swissprot;acc:p53805]	RCAN1		218.508
	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	MAP1LC3B	Low confidence	152.998	156.39	1.02217
1331	calcipressin 3 (down syndrome candidate region 1-like protein 2) (myocyte-enriched calcineurin interacting protein 3) (mcip3). [swissprot;acc:q9uka8]	RCAN3	High confidence	218.509	213.649	1.02275
	ras-related protein rab-11a (rab-11) (24kg) (yl8). [swissprot;acc:p24410]	RAB11A	Low confidence	203.955	199.531	1.02217
1332	alpha-2-macroglobulin receptor-associated protein precursor (alpha-2-mrap) (low density lipoprotein receptor-related protein- associated protein 1) (rap). [swissprot;acc:p30533]	LRPAP1		203.765	199.349	1.02215
	cytochrome oxidase biogenesis protein oxa1, mitochondrial precursor (oxa1-like protein) (oxa1hs). [swissprot;acc:q15070]	OXA1L	High confidence	220.681	215.78	1.02271
1333	60s ribosomal protein l34, mitochondrial precursor (l34mt). [swissprot;acc:q9bq48]	MRPL34
	dna replication licensing factor mcm6 (p105mcm). [swissprot;acc:q14566]	MCM6	Low confidence	202.379	197.993	1.02215
1334	jm4 protein. [refseq;acc:nm_007213]	PRAF2	High confidence	199.643	204.163	1.02264
	minichromosome maintenance protein 10 isoform 2; homolog of yeast mcm10. [refseq;acc:nm_018518]	MCM10	Low confidence	202.379	197.993	1.02215
1335	cytochrome b5 reductase 1 (b5r.1). [refseq;acc:nm_016243]	CYB5R1		200.614	196.269	1.02214
	cytoskeleton related vitamin a responsive protein; glutamate transporter eeac1-associated protein; dermal papilla derived protein 11; putative mapk activating protein pm27. [refseq;acc:nm_006407]	ARL6IP5	High confidence	199.771	204.287	1.02261
1336	dna-repair protein complementing xp-g cells (xeroderma pigmentosum group g complementing protein) (dna excision repair protein ercc-5). [swissprot;acc:p28715]	ERCC5	Low confidence	207.328	202.837	1.02214
	n-acetylgalactosamine kinase (ec 2.7.1.-) (galnac kinase) (galactokinase 2). [swissprot;acc:q01415]	GALK2	High confidence	215.162	210.412	1.02257
1337	galactose-1-phosphate uridylyltransferase (ec 2.7.7.12) (gal-1-p uridylyltransferase) (udp-glucose--hexose-1-phosphate uridylyltransferase). [swissprot;acc:p07902]	no value
	nadh-cytochrome b5 reductase (ec 1.6.2.2) (b5r). [swissprot;acc:p00387]	CYB5R3	Low confidence	200.614	196.269	1.02214
1338	dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor (ec 2.3.1.12) (e2) (pdc-e2) (70 kda mitochondrial autoantigen of primary biliary cirrhosis) (pbc) (m2 antigen complex 70 kda subunit). [swissprot;acc:p10515]	DLAT		204.159	199.739	1.02213
	udp-glucose 4-epimerase (ec 5.1.3.2) (galactowaldenase) (udp- galactose 4-epimerase). [swissprot;acc:q14376]	GALE	High confidence	215.162	210.412	1.02257
1339	choline/ethanolaminephosphotransferase. [refseq;acc:nm_006090]	CEPT1	Low confidence	187.632	183.57	1.02213
	epididymal secretory protein e1 precursor (niemann-pick disease type c2 protein) (epi-1) (he1) (epididymal secretory protein 14.6) (esp14.6). [swissprot;acc:q15668]	NPC2	High confidence	205.204	200.71	1.02239
1340	histone-lysine n-methyltransferase, h3 lysine-9 specific 2 (ec 2.1.1.43) (histone h3-k9 methyltransferase 2) (h3-k9-hmtase 2) (suppressor of variegation 3-9 homolog 2) (su(var)3-9 homolog 2). [swissprot;acc:q9h5i1]	SUV39H2		226.433	231.491	1.02234
	tbc1 domain family member 5. [swissprot;acc:q92609]	TBC1D5	Low confidence	203.872	199.458	1.02213
1341	eukaryotic translation initiation factor 2 subunit 1 (eukaryotic translation initiation factor 2 alpha subunit) (eif-2-alpha) (eif- 2alpha) (eif-2a). [swissprot;acc:p05198]	EIF2S1	High confidence	226.433	231.491	1.02234
	reversion-inducing cysteine-rich protein with kazal motifs precursor (hreck) (suppressor of tumorigenicity 15) (st15). [swissprot;acc:o95980]	RECK	Low confidence	187.632	183.57	1.02213
1342	choline phosphotransferase 1; cholinephosphotransferase 1 alpha; cholinephosphotransferase 1. [refseq;acc:nm_020244]	CHPT1		187.631	183.569
	histone-lysine n-methyltransferase, h3 lysine-9 specific 1 (ec 2.1.1.43) (histone h3-k9 methyltransferase 1) (h3-k9-hmtase 1) (suppressor of variegation 3-9 homolog 1) (su(var)3-9 homolog 1). [swissprot;acc:o43463]	SUV39H1	High confidence	226.433	231.491	1.02234
1343	m-phase inducer phosphatase 1 (ec 3.1.3.48) (dual specificity phosphatase cdc25a). [swissprot;acc:p30304]	CDC25A		258.558	252.916	1.02231
	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	MAP1LC3A	Low confidence	153.029	156.416	1.02213
1344	casein kinase ii, alpha' chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19784]	CSNK2A2		204.058	199.639
	exonuclease 1 isoform b; rad2 nuclease family member, homolog of s. cerevisiae exonuclease 1. [refseq;acc:nm_006027]	EXO1	High confidence	216.772	221.594	1.02224
1345	esterase d (ec 3.1.1.1). [swissprot;acc:p10768]	ESD	Low confidence	200.431	196.093	1.02212
	phd finger protein 9. [refseq;acc:nm_018062]	FANCL	High confidence	216.772	221.594	1.02224
1346	small optic lobes homolog; small optic lobes, drosophila, homolog of. [refseq;acc:nm_005632]	SOLH
	vacuolar protein sorting 35 (vesicle protein sorting 35) (hvps35) (maternal-embryonic 3). [swissprot;acc:q96qk1]	VPS35	Low confidence	201.165	196.812	1.02212
1347	lipoic acid synthetase, mitochondrial (lip-syn) (lipoate synthase) (hussy-01) (fragment). [swissprot;acc:o43766]	LIAS	High confidence	204.961	209.517	1.02223
	mitochondrial ribosomal protein l24. [refseq;acc:nm_024540]	MRPL24	Low confidence	205.323	200.881	1.02211
1348	peptidyl-prolyl cis-trans isomerase, mitochondrial precursor (ec 5.2.1.8) (ppiase) (rotamase) (cyclophilin f). [swissprot;acc:p30405]	PPIF		201.458	197.1
	zinc finger protein zic 1 (zinc finger protein of the cerebellum 1). [swissprot;acc:q15915]	ZIC1	High confidence	218.569	213.832	1.02215
1349	carboxypeptidase a5. [refseq;acc:nm_080385]	CPA5	Low confidence	187.671	183.613	1.0221
	zinc finger protein zic 3 (zinc finger protein of the cerebellum 3). [swissprot;acc:o60481]	ZIC3	High confidence	218.572	213.841	1.02212
1350	t-complex protein 1, theta subunit (tcp-1-theta) (cct-theta). [swissprot;acc:p50990]	CCT8	Low confidence	201.762	197.399	1.0221
	zinc finger protein zic 2 (zinc finger protein of the cerebellum 2). [swissprot;acc:o95409]	ZIC2	High confidence	218.574	213.847

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.